2017
DOI: 10.1016/j.cois.2017.07.005
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Abstract: 1Manipulating amino acid (AA) intake in Drosophila can profoundly affect lifespan and reproduction. Remarkably, AA manipulation can uncouple the commonly observed trade-off between these traits. This finding seems to challenge the idea that this trade-off is due to competitive resource allocation, but here we argue that this view might be too simplistic. We also discuss the mechanisms of the AA response, mediated by the IIS/TOR and GCN2 pathways. Elucidating how these pathways respond to specific AA will likel… Show more

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Cited by 24 publications
(27 citation statements)
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References 48 publications
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“…The contrast between large differences in optimal diet but similar responses to diet manipulation raises the question of how males and females differ in their diet-dependent regulation of metabolism and reproductive allocation. Due to the predominant focus on female responses to nutrition, we currently know relatively little about the degree to which regulation is shared or differs between the sexes [21], in particular at the molecular level.…”
Section: Introductionmentioning
confidence: 99%
“…The contrast between large differences in optimal diet but similar responses to diet manipulation raises the question of how males and females differ in their diet-dependent regulation of metabolism and reproductive allocation. Due to the predominant focus on female responses to nutrition, we currently know relatively little about the degree to which regulation is shared or differs between the sexes [21], in particular at the molecular level.…”
Section: Introductionmentioning
confidence: 99%
“…Macronutrient restriction and restrictions in food availability are DR regimens that have repeatedly been shown to prolong lifespan. Numerous different diets that are restricted with regard to particular macronutrients have been described, but those characterized by substantially lower protein content are of particular interest because they have been reproducibly associated with longer life . Indeed, it has been hypothesized that the beneficial effects of CR on lifespan can be attributed mainly to the associated reduction in protein intake; however, this view has recently been challenged .…”
Section: Cr Macronutrient Restriction and Time Restricted Food Intakementioning
confidence: 99%
“…However, recent analyses have challenged this view and claimed that, at least in rodents, it is the lower energy contribution of a CR diet that is causally linked to lifespan extension, rather than protein restriction . These seemingly conflicting results were obtained in studies carried out using different models: groups working with invertebrates have repeatedly identified protein restriction as causing lifespan extension, whereas other groups working with rodents have identified energy restriction as the cause . This has led to the hypothesis that the mechanism of lifespan extension resulting from nutrient restriction (energy or protein) is not phylogenetically conserved .…”
Section: Cr Macronutrient Restriction and Time Restricted Food Intakementioning
confidence: 99%
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