Paul-Albert Koenig, Eric Spooner, Norio Kawamoto, Jack L. Strominger, Hidde L. Ploegh
Multiple Sclerosis (MS) is an autoimmune disease that affects the central nervous system. One approved treatment for relapsing forms of MS is YEAK, a random copolymer of the amino acids Tyr, Glu, Ala and Lys. YFAK, a second-generation copolymer composed of Tyr, Phe, Ala and Lys, is more successful in treating experimental autoimmune encephalitis (EAE), a mouse model of MS. Although originally designed and optimized based on the autoantigen myelin basic protein (MBP) and the MBP-derived peptide MBP85-99 presen…
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