J. Neurosci. Res. volume 86, issue 5, P1096-1105 2008 DOI: 10.1002/jnr.21567 View full text
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Takaaki Nishimoto, Takeshi Kihara, Akinori Akaike, Tetsuhiro Niidome, Hachiro Sugimoto

Abstract: Preconditioning of sublethal ischemia exhibits neuroprotection against subsequent ischemia-induced neuronal death. It has been indicated that glutamate, an excitatory amino acid, is involved in the pathogenesis of ischemia-induced neuronal death or neurodegeneration. To elucidate whether prestimulation of glutamate receptor could counter ischemia-induced neuronal death or neurodegeneration, we examined the effect of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), an ionotropic subtype of glutamat…

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