1996
DOI: 10.1523/jneurosci.16-24-08115.1996
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Abstract: Amiloride, an epithelial sodium channel blocker, suppresses the responsiveness of narrowly tuned sodium-responsive taste afferents when orally applied in the rat. Broadly tuned salt-responsive taste afferents, which respond to sodium and nonsodium salts and acids, are relatively unaffected by the drug. We used amiloride treatment to examine the consequences of the specific removal of input from narrowly tuned sodium-responsive afferents on taste discrimination. Five water-restricted rats were trained in a gust… Show more

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Cited by 139 publications
(122 citation statements)
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“…However the strain distributions of responses to other KCl concentrations and to CaCl 2 did not correlate with responsiveness to quinine and, therefore, cannot be explained by differences in sensitivity to quinine-like bitterness. The strain differences in response to 200 mM KCl were also similar to the strain differences in responses to NaCl (Tables 2 and 3), which could be due to the salty component of KCl taste in humans and other animals (22,24,27,34).We found no strong evidence for a correlation between blood pressure and fluid consumption. The most consistent relationship between them was for raw water intake (when water was given alone, Fig.…”
supporting
confidence: 70%
“…However the strain distributions of responses to other KCl concentrations and to CaCl 2 did not correlate with responsiveness to quinine and, therefore, cannot be explained by differences in sensitivity to quinine-like bitterness. The strain differences in response to 200 mM KCl were also similar to the strain differences in responses to NaCl (Tables 2 and 3), which could be due to the salty component of KCl taste in humans and other animals (22,24,27,34).We found no strong evidence for a correlation between blood pressure and fluid consumption. The most consistent relationship between them was for raw water intake (when water was given alone, Fig.…”
supporting
confidence: 70%
“…Because nicotine activates taste pathways that are not common to quinine, we hypothesized that the two tastants can be discriminated. This hypothesis was tested in rats using a two alternative choice test (29) where animals were exposed to either nicotine or quinine and were required to report, by pressing one of two levers, which tastant had been presented. When the correct lever was pressed, access to a water reward was granted, whereas if the incorrect lever was chosen, the animal was punished with 30 s of timeout.…”
Section: Resultsmentioning
confidence: 99%
“…otine solutions were replaced by either water (control session), or nicotine and mecamylamine (0.3 mM) (test session) (29). In both cases, to avoid intrasession learning, access to water rewards was not contingent upon the animal's response but was delivered with a fixed 0.8 probability.…”
Section: Resultsmentioning
confidence: 99%
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“…In rodents, treating the anterior tongue with amiloride, an epithelial Na + channel blocker, disrupts performance on sodium discrimination tasks (Spector et al, 1996) and inhibits chorda tympani responses to NaCl (Heck et al, 1984). Consequently, it is believed that sodium taste is transduced via the influx of Na + through epithelial sodium channels (ENaC) in the anterior tongue.…”
Section: Peripheral Gustatory Processingmentioning
confidence: 99%