Biochemical Pharmacology volume 80, issue 7, P1012-1020 2010 DOI: 10.1016/j.bcp.2010.06.016 View full text
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Mickael Bourge, Asma Tlili, Sophie Dupré-Crochet, Oliver Nüβe, Jean-Claude Sulpice

Abstract: During brain or cardiac ischemia/reperfusion neutrophils are recruited and activated contributing to inflammation and tissue damage. Neutrophils are removed from inflamed tissues by phosphatidylserine-dependent phagocytosis. Production of reactive oxygen species by the neutrophil NADPH-oxidase is known to affect phosphatidylserine externalization. Amiloride derivatives are inhibitors of the sodium-proton exchanger providing substantial protection in animal models of brain and cardiac ischemia/reperfusion injur…

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