Amifostine Use in Radiation-Induced Kidney Damage

Kaldir, M.; Cosar-Alas, Rusen; Çermik, Tevfik Fikret; Yurut-Caloglu, Vuslat; Saynak, Mert; Altaner, Semsi; Çaloğlu, Murat; Koçak, Zafer; Tokatli, Füsun; Türe, Mevlüt; Parlar, Şule; Uzal, Cem

doi:10.1007/s00066-008-1777-7

Cited by 18 publications

(10 citation statements)

References 28 publications

(42 reference statements)

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“…In some experimental rat models, amifostine given prior to RT was found to confer functional and histopathological protection. 38 Similarly, there was a significant reduction in MDA and apoptosis with amifostine in our study. This might reflect the fact that the degenerative changes observed in the germinal epithelium may be associated with increased generation of ROS.…”

Section: Discussionsupporting

confidence: 73%

<div>Examination of the effect of ovarian radiation injury induced by hysterosalpingography on ovarian proliferating cell nuclear antigen and the radioprotective effect of amifostine: an experimental study</div>

Can

Atılgan

Pala

et al. 2018

DDDT

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AimThe aim of this study was to examine the effect of amifostine on cellular injury in the ovarian tissue induced by hysterosalpingography (HSG).MethodsIn total, forty 4-month old female Wistar Albino rats were assigned into 8 groups. Each group contained 5 rats. Group 1 (G1): rats were decapitated without any procedure. Group 2 (G2): rats were decapitated after 3 hours of total body irradiation. Group 3 (G3): rats were decapitated 3 hours after HSG procedure. Group 4 (G4): rats were decapitated 3 hours after HSG procedure performed 30 min after receiving amifostine 200 mg/kg intraperitoneally. Group 5 (G5): rats were decapitated after 1 month without any procedure. Group 6 (G6): rats were decapitated after 1 month of total body irradiation. Group 7 (G7): rats were decapitated 1 month after HSG procedure. Group 8 (G8): rats were decapitated 1 month after HSG procedure performed 30 min after receiving amifostine 200 mg/kg intraperitoneally. After rats were decapitated under general anesthesia in all groups, blood samples were obtained and bilateral ovaries were removed. One of the ovaries was placed in 10% formaldehyde solution for histological germinal epithelial degeneration, apoptosis and proliferating cell nuclear antigen scoring. The other ovary and blood sera were stored at −80°C. TNF-α, total antioxidant status, total oxidant status, and malondialdehyde levels were studied in tissue samples and anti-mullerian hormone levels in blood samples.ResultsAt the end of the first month, there was significant ovarian germinal epithelium degeneration. Proliferating cell nuclear antigen immunoreactivity was significantly reduced in all other groups when compared with G1 and G5.ConclusionIn conclusion, amifostine could significantly reduce the ovarian cellular injury induced by HSG.

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Section: Discussionsupporting

confidence: 73%

<div>Examination of the effect of ovarian radiation injury induced by hysterosalpingography on ovarian proliferating cell nuclear antigen and the radioprotective effect of amifostine: an experimental study</div>

Can

Atılgan

Pala

et al. 2018

DDDT

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“…Amifostine is an organic thiophosphate ester prodrug and must be activated by alkaline phosphatase to be converted into an active sulfhydryl compound 2009 (Kaldir et al, 2008;Levi et al, 2002). It has been shown that amifostine can ameliorate functional renal damage in rat kidneys (Caloglu et al, 2009;Rolleman et al, 2007).…”

Section: Discussionmentioning

confidence: 99%

Comparison of Protective Effects of Melatonin and Amifostine on Radiation-Induced Renal Oxidative Stress in Rats

Çakına

Gülyaşar

Özen

et al. 2020

J Hellenic Vet Med Soc

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In this study, we aimed to compare the protective effects of melatonin and amifostine on radiation-induced oxidative stress. Fifty female Wistar rats (3-4 months old, weighing 200±25 g) were divided into five groups (with ten rats each) and treated as follows: control (Cont), radiotherapy alone (RT), radiotherapy + amifostine (RT+A-MI), radiotherapy + melatonin (RT+MEL), radiotherapy + amifostine + melatonin (RT+AMI+MEL). Rats were irradiated individually with a single dose of 8 Gy and amifostine (200 mg/kg) and melatonin (10 mg/kg) was administered to rats 30 minutes before irradiation. At the end of this follow-up period (72 hours) the rats were sacrificed. Spectrophotometric Analysis has been performed to kidney tissue samples. As a result of statistical comparison between groups after RT, total antioxidant capacity (TAC) decreased, total oxidant status (TOS) and oxidative stress index (OSI) increased, although the statistically significant change was only for OSI (p = 0.030). Addition of AMI or MEL to RT increased TAC and OSI significantly (p = 0.000), but there was no additive effect for TAC and OSI when both drugs were given together (p = 1.000, p = 0.172, respectively). In terms of TOS, statistically significant increasing was only for AMI (p = 0.000). There was protective effect when both drugs were given together against on Radiation-Induced Renal Oxidative Stress.

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“…In an effort to find a way of reversing the irradiation damage, two agents were studied in a rat model of radia- tion nephropathy βC and WGO. Rats are suitable animals for experimental models to estimate renal impairment as they similar to human structure (Kaldir et al, 2008).…”

Section: Discussionmentioning

confidence: 99%

Early experience of laparoscopic cholecystectomy in acutely inflamed gallbladder

Handoz¹,

Alsagban²

2018

Int. J. Res. Ph. Sci.

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Radiation nephropathy has appeared as a substantial complica tion of radionuclide radiotherapy. Thus, the requirement for a protective agent against radiation injury is evident. The present study explored the potential effects of beta-carotene (βC) as well as, wheat germ oil (WGO) on gamma -irradiation resulted in oxidative stress and renal nephropathy in rats. Rats were divided into six groups: normal control group, βC group, WGO group, irradiated (IRR) group, βC+IRR group, WGO +IRR group. Oral administration of βC (10 mg /kg) or WGO (80 mg/kg) for 7 days after γ-irradiation (7.5 Gy) have significantly minimized the severity of biochemical changes, which was evidenced by a significant diminution in the level of malondaldhyde (MDA) in kidney, urea, creatinine as well as Creactive protein (CRP) along with an increase i n Glutathione (GSH) level, superoxide dismutase activity (SOD), urea and creatinine clearance comparing to the corresponding values of irradiated rats (P < 0.05). Histopathological examination of kidney tissues further confirms the biochemical records. Therefore, it is concluded that, βC as well as, WGO may reduce radiation nephropathy and enhance recovery processes after radiation exposure.

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Amifostine Use in Radiation-Induced Kidney Damage

Abstract: Static kidney scintigraphy represents an objective and reproducible method to noninvasively investigate kidney function following irradiation. Amifostine produced a significant reduction in radiation-induced loss of renal function.

Cited by 18 publications

References 28 publications

<div>Examination of the effect of ovarian radiation injury induced by hysterosalpingography on ovarian proliferating cell nuclear antigen and the radioprotective effect of amifostine: an experimental study</div>

<div>Examination of the effect of ovarian radiation injury induced by hysterosalpingography on ovarian proliferating cell nuclear antigen and the radioprotective effect of amifostine: an experimental study</div>

Comparison of Protective Effects of Melatonin and Amifostine on Radiation-Induced Renal Oxidative Stress in Rats

Early experience of laparoscopic cholecystectomy in acutely inflamed gallbladder

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