American Onchocerciasis

Goldman, Leon

doi:10.1001/archderm.1944.01510180035006

Cited by 9 publications

(3 citation statements)

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“…Xenodiagnosis.--Xenodiagnosis is the diagnosis of cases of disease by dissecting flies fed on suspected persons (Hinman, 1933). Ashburton (Strong & others, 1934, p. 103) suggested that it might be used for detecting microfilariae of Wuchereria bancrofti when very few were present, and Goldman (1944) referred to its use in the study of onchocerciasis.…”

Section: Section-cuttingmentioning

confidence: 99%

Simulium damnosumand its Relation to Onchocerciasis in the Anglo-Egyptian Sudan

Lewis¹

1953

Bull. Entomol. Res.

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Observations were made chiefly in the southern Sudan, particularly at Mvolo where human onchocerciasis is common. The country and climate are briefly described.Methods are described at some length.The distribution of S. damnosum and places where it is known to be abundant are shown on a map. It does not appear to exist at the Fola Rapids.Changes in certain organs were studied, chiefly in relation to the approximate estimation of age and (particularly in the case of the mid-gut and peritrophic membrane) to the movements of microfilariae. Recently emerged flies can frequently be readily detected by the clarity of the halteres (in which glycogen has not yet been stored) and the presence of abundant fat body, and by less conspicuous features such as the absence of an old peritrophic membrane. The oesophageal diverticulum often contains plant sugars and particles of grit but never blood.The peritrophic membrane is formed at the time of a blood meal by the epithelium of the expanding part of the mid-gut. It is a laminated chitinous envelope completely surrounding the blood and remains unbroken for 24 hours or more. When very large numbers of microfilariae are ingested they appear to prevent the completion of the membrane so that blood quickly passes to the hind-gut.

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Section: Section-cuttingmentioning

confidence: 99%

Simulium damnosumand its Relation to Onchocerciasis in the Anglo-Egyptian Sudan

Lewis¹

1953

Bull. Entomol. Res.

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“…Moreover acute and chronic edema reactions were more frequent on the face and may resemble angioneurotic edema, while chronic edema may be comparable to myxedema. The cause of edema was attributed to a vascular reaction as evidenced by lymphocytic perivascular inflammatory infiltrates 2 . They also documented that the onchodermatitis often shows microfilariae on skin biopsy specimens.…”

mentioning

confidence: 98%

“…In our recent article on cutaneous findings in onchocerciasis, 1 we focused on Old World onchocerciasis and the need to add the pioneering work of Leon Goldman in the 1940s on American onchocerciasis 2,3 . Working at a variety of research sites in Latin America, including those in Yepocapa, Guatemala, and Chiapas, Mexico, Goldman studied onchodermatitis clinically and histologically, categorizing it in a classic study coauthored with Luis Figueroa Ortiz as divisible into four categories: 1.…”

mentioning

confidence: 99%