American cutaneous leishmaniasis in two cats from Rio de Janeiro, Brazil: first report of natural infection with Leishmania (Viannia) braziliensis

Schubach, Tânia Maria Pacheco; Figueiredo, Fabiano Borges; Pereira, Sandro Antônio; Madeira, M.F.; Santos, Israel Gomes de Amorim; Andrade, Moacir Vieira de; Cuzzi, Tullia; Marzochi, Mauro Célio de Almeida; Schubach, Armando

doi:10.1016/s0035-9203(03)00040-3

Cited by 61 publications

(53 citation statements)

References 12 publications

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“…However, cutaneous ulcerative lesions due to Leishmania is a frequent finding in canine leishmaniosis as well as in human leishmaniosis (Hepburn, 2003). Moreover, in the few cases of feline leishmaniosis that have been reported since the first case described by Sergent in Alger, involvement of the skin is often described as well (de Souza et al, 2005;Craig et al, 1986;Dunan et al, 1989;Barnes et al, 1993;Bonfante-Garrido et al, 1991;Laruelle-Magalon & Toga, 1996;Pennisi, 2002;Schubach et al, 2004;San Martin Mouriz Savani et al, 2004). In this context, it could be questioned whether the ulceration might have been induced firstly by the carcinoma or the parasite or both.…”

Section: Discussionmentioning

confidence: 99%

Leishmaniosis due toLeishmania infantumin a FIV and FeIV positive cat with a squamous cell carcinoma diagnosed with histological, serological and isoenzymatic methods

Grevot

Hugues²,

Marty³

et al. 2005

Parasite

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Section: Discussionmentioning

confidence: 99%

Leishmaniosis due toLeishmania infantumin a FIV and FeIV positive cat with a squamous cell carcinoma diagnosed with histological, serological and isoenzymatic methods

Grevot

Hugues²,

Marty³

et al. 2005

Parasite

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“…Παρά το σχετικά περιορισμένο αριθμό μελετών, είναι γνωστό ότι και οι γάτες μπορούν να μολυνθούν στη φύση από οκτώ τουλάχιστον είδη του γένους Leishmania (L. infantum/chagasi, L. tropica, L. major, L. amazonensis, L. mexicana, L. venezuelensis, L. braziliensis xaiL. panamensis), που συνήθως είναι τα ίδια με εκείνα που ευθύνονται για τη μόλυνση του ανθρώπου και του σκύλου στη συγκεκριμένη γεω γραφική περιοχή (Craig et al 1986, Morsy and Abou el Seoud 1994, Bonfante-Garrido et al 1996, Poli et al 2002, Mancianti 2004, Schubach et al 2004, Grevot et al 2005, Ayllon et al 2008, da Silva et al 2008, Sarkari et al 2009, Souza et al 2009, Hatam et al 2010. Όπως και στο σκύλο, ιδιαίτερη σημασία για τις μεσογειακές χώρες έχει η μόλυνση από την L. infantum, που, αν και τις περισσότερες φορές είναι ασυμπτωματική, φαίνεται ότι είναι αρκετά συχνή, γεγονός που εγείρει υποψίες για τον πιθανό ρόλο της γάτας ως «δευτερογενούς δεξαμενής» του πρω τόζωου στη φύση.…”

Section: περιληψη από τις αρχές του 20unclassified

Feline leishmaniosis due to Leishmania infantum (syn. L. chagasi)

Chatzis

Saridomichelakis

Koutinas

2018

J Hellenic Vet Med Soc

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From the beginning of the 20th century, feline infections by at least eight different Leishmania species have been sporadically reported, worldwide. In the Mediterranean countries, feline infection imposed by L. infantum, the aetiological agent of canine leishmaniosis and human visceral and cutaneous leishmaniasis, is of particular importance, because cats may represent a "secondary reservoir" of the parasite in the nature. Although the prevalence of the infection may be as high as 60%, most infected cats are resistant and remain asymptomatic, while only occasionally, they may present cutaneous and/or ocular lesions, and perhaps systemic clinical signs. In feline leishmaniosis, ulcers and nodules, usually localized at mucocutaneous junctions, planum nasale, face and ear pinnae, constitute the mainstream of cutaneous lesions. In a small number of cases, exfoliative dermatitis and pododermatitis have been noted, whereas a cause-and-effect relationship, between feline leishmaniosis and the presence of papules, crusts and generalized alopecia remains speculative. Ocular lesions, such as those associated with conjunctivitis, (ulcerative) keratitis, posterior or anterior uveitis, chorioretinitis and panopthalmitis are relatively common. The only systemic signs that have been constantly associated with feline leishmaniosis are peripheral lymphadenomegaly, splenomegaly, hepatomegaly and chronic nephritis that may lead to chronic renal failure. The most consistent laboratory abnormality is hyperglobulinaemia that is usually polyclonal. Feline leishmaniosis can co-exist with various other infectious and non-infectious diseases that may alter its clinical picture and/or influence the immunological response of the infected cat. Diagnosis is usually based on the results of cytology,histopathology, immunohistochemistry, culture, serology and polymerase chain reaction (PCR). Apart from the advantages and limitations inherent to each of these methods, their diagnostic value depends on many factors, such as the biological sample being used, the reagents and the particular technique employed. Leishmania amastigotes can be detected by applying bone marrow, lymph node, spleen, cutaneous and ocular cytology, histopathology, and/or immunohistochemistry, which are 100% specific. Serology may underestimate or even overestimate the frequency of the infection in the endemic areas, depending on the methodology and the cut-off value, whereas PCR, that can be performed on the tissues mentioned before, plus the peripheral blood may be a better option for epidemiological studies. Although a uniformly effective treatment for symptomatic cats has not been established yet, long-term allopurinol administration, along with the management of any concurrent diseases, is the only treatment to suggest at moment.

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“…and L. shawi (BRASIL, 2006a). Among these species, three have already been isolated in Brazilian cats: L. braziliensis (SCHUBACH et al, 2004), L. amazonensis (SOUZA et al, 2005), and L. chagasi (VIDES et al, 2011), whereas L. venezuelensis (BONFANTE-GARRIDO et al, 1996) and L. mexicana (TRAINOR et al, 2010) infect cats in other countries.…”

Section: Epidemiology and Public Healthmentioning

confidence: 99%

Clinical and epidemiological aspects of feline leishmaniasis in Brazil

et al. 2015

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Tegumentary and visceral leishmaniasis are severe and unfortunately common parasitic diseases in Brazil. Among domestic animals, dogs are considered the main urban reservoir of the protozoan parasites, however, there is evidence that infected cats can also contribute towards the disease pool. The number of cats diagnosed with leishmaniasis has greatly increased in the last few years, highlighting the importance of thorough investigations on the role of the cat in the epidemiological cycle of the disease and in public health related issues. The main clinical manifestations of leishmaniasis suffered by cats, even when infected with Leishmania chagasi, a viscerotropic species, are skin abnormalities, which can be confounded with multiple other diseases. Indirect ELISA should be used as a screening test in epidemiological investigations for being a sensitive technique, followed by more specific laboratory tests. The standardization and validation of rapid, economical and reproducible diagnostic methods, to be employed in epidemiological surveillance, are still required. Key words: Leishmania spp., cat, epidemiology, diagnosis, zoonosis, prevalence ResumoLeishmaniose tegumentar e visceral são doenças parasitárias graves e, infelizmente, comuns no Brasil. Entre os animais domésticos, o cão é considerado o principal reservatório urbano do parasito protozoário; no entanto, há indícios de que gatos infectados também possam contribuir para essas doenças. O número de gatos com diagnóstico de leishmaniose aumentou muito nos últimos anos, destacando a importância de investigações aprofundadas sobre o papel desse hospedeiro no ciclo epidemiológico da doença e em Saúde Pública. As principais manifestações clínicas da leishmaniose felina são anormalidades na pele, o que pode ser confundida com várias outras doenças, mesmo em casos de infecção por Leishmania chagasi, uma espécie viscerotrópica. ELISA indireto poderia ser usado como teste de triagem em investigações epidemiológicas, por ser um método sensível, seguido de exames laboratoriais mais específicos. A padronização e validação de métodos de diagnóstico rápidos, econômicos e reprodutíveis a serem empregados na vigilância epidemiológica ainda são necessárias.

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American cutaneous leishmaniasis in two cats from Rio de Janeiro, Brazil: first report of natural infection with Leishmania (Viannia) braziliensis

Abstract: We describe the isolation of Leishmania (Viannia) braziliensis from two female cats with American cutaneous leishmaniasis in Rio de Janeiro, Brazil. The isolates were identified as L. (V.) braziliensis by isoenzyme electrophoresis.

Cited by 61 publications

References 12 publications

Leishmaniosis due toLeishmania infantumin a FIV and FeIV positive cat with a squamous cell carcinoma diagnosed with histological, serological and isoenzymatic methods

Leishmaniosis due toLeishmania infantumin a FIV and FeIV positive cat with a squamous cell carcinoma diagnosed with histological, serological and isoenzymatic methods

Feline leishmaniosis due to Leishmania infantum (syn. L. chagasi)

Clinical and epidemiological aspects of feline leishmaniasis in Brazil

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