Ameloblastic fibro-odontosarcoma of the mandible: imaging findings

Wang, S; Shi, Huimin; Wang, P; Yu, Qiang

doi:10.1259/dmfr/80061108

Cited by 17 publications

(33 citation statements)

References 16 publications

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“…AFOS is an extremely rare subtype of odontogenic sarcoma. Seventeen cases have been reported in the literature to date . In contrast, although still rare, 66 cases of AFS had been published in the literature in 2007 so that incidence, recurrence rate, and histologic behavior are better understood .…”

Section: Discussionmentioning

confidence: 99%

“…Seventeen cases have been reported in the literature to date. [1,[6][7][8][9] In contrast, although still rare, 66 cases of AFS had been published in the literature in 2007 so that incidence, recurrence rate, and histologic behavior are better understood. [6] With this report, we contribute to better understanding of the rare disease entity of AFOS and highlight the potential role of chemotherapy in its management.…”

Section: Discussionmentioning

confidence: 99%

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Chemotherapy responsiveness in a patient with multiply relapsed ameloblastic fibro‐odontosarcoma of the maxilla

Gatz

Thway

Mandeville

et al. 2015

Pediatric Blood & Cancer

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Ameloblastic fibro‐odontosarcoma (AFOS) is an extremely rare malignant odontogenic tumor. Complete surgical excision is the treatment of choice. Deaths due to disease recurrence and/or progression are documented. Here, we report the case of a 15‐year‐old female with multiple recurrent AFOS. She responded to chemotherapy with ifosfamide and doxorubicin consolidated by stereotactic reirradiation using cyberknife and remained in complete remission 14 months from the end of reirradiation therapy. Chemotherapy with ifosfamide and doxorubicin should be considered in advanced cases of AFOS. Pediatr Blood Cancer © 2015 The Authors. Pediatric Blood & Cancer Published by Wiley Periodicals, Inc.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Chemotherapy responsiveness in a patient with multiply relapsed ameloblastic fibro‐odontosarcoma of the maxilla

Gatz

Thway

Mandeville

et al. 2015

Pediatric Blood & Cancer

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“…Seventeen publications reporting 8 AFDS [2,7-13] and 9 AFOS [14][15][16][17][18][19][20][21][22] were included in the present review. Table 1 presents the details of each case separately.…”

Section: Description Of the Studies And Analysesmentioning

confidence: 99%

Ameloblastic fibrodentinosarcoma and ameloblastic fibro-odontosarcoma: A systematic review

Gomez

2018

Journal of Stomatology, Oral and Maxillofacial Surgery

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The purpose of the present review was to integrate the available data published on ameloblastic fibrodentinosarcoma (AFDS) and ameloblastic fibro-odontosarcoma (AFOS) into a comprehensive analysis of their clinical/radiologic features. An electronic search was undertaken in July/2017. Eligibility criteria included publications having enough clinical/radiological/histological information to confirm the diagnosis. Seventeen publications (8 AFDS, 9 AFOS) were included. The patients with the two different lesions had a similar mean age. The lesions were both more prevalent in mandibles than in maxillae, all showed bone expansion and similar rates of cortical bone perforation, tooth displacement, and locular appearance at radiological exams. Mean follow-up time was higher for AFDS, and the mean size of the lesions were larger for AFDS, although without a statistically significant difference. None of AFDS recurred, while 2 AFOS recurred. As only few cases of AFDS and AFOS have been reported, additional reports are necessary to add evidence to the study of clinical and radiologic features of these lesions.

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“…(4-6,9-13,16-113). Papers describing clinicopathological features similar to those described for AFS were included in the first instance (4,5,(9)(10)(11)(12)(13)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(28)(29)(30)32,(34)(35)(36)(37)(38)(39)42,43,(67)(68)(69)(70)(71)(72)(74)(75)(76)(77)(78)(79)(80)(81)(82)(83)(84)(85)(86)(87)(88)(89)91,…”

Section: Systematic Literature Reviewmentioning

confidence: 99%

Ameloblastic Fibrosarcoma: A Case Report and Literature Review

et al. 2017

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Here is described a case of ameloblastic fibrosarcoma (AFS) affecting the posterior mandible of a woman who was treated surgically and recovered without signs of recurrence or metastasis after 12 years of follow-up. Tumor sections were immunostained for cell cycle, epithelial and mesenchymal markers. Immunohistochemical analysis evidenced high Ki-67 positivity in stromal cells (mean of 20.9 cells/High power field). Epithelial cells displayed strong positivity for p53, p63 and cytokeratin 19. In addition to the case report, a systematic review of current knowledge is presented on the AFS's clinical-demographic features and prognostic factors. Based on the review, 88/99 cases were diagnosed as AFS, 9/99 as ameloblastic fibro-odontosarcoma and 2/99 as ameloblastic fibrodentinosarcoma. All these lesions displayed very similar clinical-demographic and prognostic features. Moreover, the review provided evidence that first treatment, regional metastasis, distant metastasis and local recurrence were significant prognostic values for malignant odontogenic mesenchymal lesions. Based on the findings, segregation among ameloblastic fibrosarcoma, ameloblastic fibrodentinosarcoma and ameloblastic fibro-odontosarcoma seems illogical, considering all these lesions have similar predilections and outcomes.

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Ameloblastic fibro-odontosarcoma of the mandible: imaging findings

Abstract: We report a histologically verified case of ameloblastic fibro-odontosarcoma (AFOS) affecting the right mandible. CT scanning showed an expansile intraosseous mass with ill-defined borders and slightly dense opacities.

Cited by 17 publications

References 16 publications

Chemotherapy responsiveness in a patient with multiply relapsed ameloblastic fibro‐odontosarcoma of the maxilla

Chemotherapy responsiveness in a patient with multiply relapsed ameloblastic fibro‐odontosarcoma of the maxilla

Ameloblastic fibrodentinosarcoma and ameloblastic fibro-odontosarcoma: A systematic review

Ameloblastic Fibrosarcoma: A Case Report and Literature Review

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