Ameliorative effects of Dictyota dichotoma on hepatotoxicity induced by gibberellic acid in albino rats

Ali, Shaimaa; Moselhy, Walaa A.; Mohamed, Hussein M.H.; Nabil, Taghreed Mohamed; El-Ela, Fatma I. Abo; Abdou, K. H.

doi:10.1007/s43188-022-00122-8

Cited by 4 publications

(3 citation statements)

References 73 publications

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“…The glycogen and total protein contents in the PAS and Bromophenol blue-stained sections, respectively, were depleted significantly in response to GA3 administration compared to normal sections. Our results agree with those revealed by Ali et al [ 103 ]. While the sections of GA3 + RJ and GA3 + CV-treated groups, which showed nearly normal contents, emphasize the hepatoprotective effect of RJ and CV.…”

Section: Discussionsupporting

confidence: 94%

“…Concerning the histological observations in the hepatic parenchyma of the GA3-treated group, there was severe cellular and nuclear degeneration, vacuolation, and apoptosis, besides dilatation and congestion of all hepatic vessels. in addition to lymphocytic infiltrations as previously revealed [ 46 , 62 , 103 ]. Vacuolar degeneration was recorded as one of the main first responses to cell injury [ 104 ].…”

Section: Discussionsupporting

confidence: 73%

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Royal Jelly and Chlorella vulgaris Mitigate Gibberellic Acid-Induced Cytogenotoxicity and Hepatotoxicity in Rats via Modulation of the PPARα/AP-1 Signaling Pathway and Suppression of Oxidative Stress and Inflammation

Khadrawy

Mohamed

Hassan

et al. 2023

Foods

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Gibberellic acid (GA3) is a well-known plant growth regulator used in several countries, but its widespread use has negative effects on both animal and human health. The current study assesses the protective effect of royal jelly (RJ) and Chlorella vulgaris (CV) on the genotoxicity and hepatic injury induced by GA3 in rats. Daily oral administration of 55 mg/kg GA3 to rats for 6 constitutive weeks induced biochemical and histopathological changes in the liver via oxidative stress and inflammation. Co-administration of 300 mg/kg RJ or 500 mg/kg CV with GA3 considerably ameliorated the serum levels of AST (aspartate aminotransferase), ALT (alanine aminotransferase), ALP (alkaline phosphatase), γGT (gamma-glutamyl transferase), total bilirubin, and albumin. Lowered malondialdehyde, tumor necrosis factor α (TNF-α), and nuclear factor κB (NF-κB) levels along with elevated SOD (superoxide dismutase), CAT (catalase), and GPx (glutathione peroxidase) enzyme activities indicated the antioxidant and anti-inflammatory properties of both RJ and CV. Also, they improved the histological structure and reduced cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) expressions along with up-regulating peroxisome proliferator activated receptor α (PPARα) and down-regulating activator protein 1 (AP-1) gene expression. Additionally, chromosomal abnormalities and mitotic index were nearly normalized after treatment with RJ and CV. In conclusion, RJ and CV can protect against GA3-induced genotoxicity and liver toxicity by diminishing oxidative stress and inflammation, and modulating the PPARα/AP-1 signaling pathway.

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Section: Discussionsupporting

confidence: 94%

Section: Discussionsupporting

confidence: 73%

Royal Jelly and Chlorella vulgaris Mitigate Gibberellic Acid-Induced Cytogenotoxicity and Hepatotoxicity in Rats via Modulation of the PPARα/AP-1 Signaling Pathway and Suppression of Oxidative Stress and Inflammation

Khadrawy

Mohamed

Hassan

et al. 2023

Foods

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“…However, previous studies have determined that GA 3 is not exempt of toxicity. The hematotoxicity of GA 3 has been studied using animal models such as rats and mice (Tuluce and Çelik 2006;Muthu et al 2011;Troudi et al 2012a;Ali et al 2021Ali et al , 2022Ahmed and Nofal 2021;Galal et al 2021;Soliman et al 2021aSoliman et al , b, 2022aBushra and Shenouda 2022), hens and quail hens (Elsebai et al 2003b;Elkomy et al 2008;Ismail 2009), and rabbits (El-Sebai 2004). Nevertheless, the impacts of GA 3 on the hematological parameters and erythron profile of fish have not been investigated (Sayed et al 2020).…”

Section: Introductionmentioning

confidence: 99%

The mitigating effect of Spirulina (Arthrospira platensis) on the hemotoxicity of gibberellic acid on juvenile tilapia (Oreochromis niloticus)

Sayed

Hamed

El-Sayed

et al. 2022

Environ Sci Pollut Res

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The use of plant growth regulators has led to environmental contamination of water bodies that occur adjacent to agricultural areas. Some of these chemicals are bioactive, not only to plants, but also to non-target exposed biota, namely of the aquatic compartment. Previous work demonstrated the establishment of hepato- and nephrotoxic effects in juvenile tilapia (Oreochromis niloticus) exposed via aquatic media to gibberellic acid (GA3), which is among the most used plant growth regulators, in agricultural practices. Here, we investigated the effect of GA3 on hematological indices, poikilocytosis, nuclear abnormalities, and genotoxic indices measured in Nile tilapia (Oreochromis niloticus), as well as the putative protective effects of dietary supplementation of Spirulina (Arthrospira platensis). Fish were evenly assorted into 5 groups: group I served as a control, and groups II–V were fed diets supplemented with Spirulina at rates of 0 g/kg, 5 g/kg, 20 g/kg, and 100 g/kg, respectively, for 2 months before being exposed to 150 mg/L GA3. The results revealed that GA3 exposure decreased significantly all hematological indices (P < 0.05), except leucocytes and mean corpuscular hemoglobin concentration (MCHC), compared to the control group (P > 0.05). GA3 exposure increased significantly the percentage of nuclear abnormalities, altered erythrocytes and the percentages of tail DNA, compared to the control group (P < 0.05). Spirulina supplementation restored the hematological, poikilocytosis, nuclear abnormalities, and the percentages of tail DNA to near normal levels. The 100 g/kg SP treatment was the most effective in attaining such effect, showing concentration-dependency. The present study reinforces our findings of the toxicity of GA3 on O. niloticus and suggests that the addition of Spirulina to fish diet can mitigate the hemotoxic effects of GA3.

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In Vivo and In Silico Studies Assessment of the Effects of Oral Exposure to 1-Methylcyclopropene on Liver Function in Male Albino Rats

Ouali,

Boukerche,

Trea

et al. 2024

Proc. Natl. Acad. Sci., India, Sect. B Biol. Sci.

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Ameliorative effects of Dictyota dichotoma on hepatotoxicity induced by gibberellic acid in albino rats

Cited by 4 publications

References 73 publications

Royal Jelly and Chlorella vulgaris Mitigate Gibberellic Acid-Induced Cytogenotoxicity and Hepatotoxicity in Rats via Modulation of the PPARα/AP-1 Signaling Pathway and Suppression of Oxidative Stress and Inflammation

Royal Jelly and Chlorella vulgaris Mitigate Gibberellic Acid-Induced Cytogenotoxicity and Hepatotoxicity in Rats via Modulation of the PPARα/AP-1 Signaling Pathway and Suppression of Oxidative Stress and Inflammation

The mitigating effect of Spirulina (Arthrospira platensis) on the hemotoxicity of gibberellic acid on juvenile tilapia (Oreochromis niloticus)

In Vivo and In Silico Studies Assessment of the Effects of Oral Exposure to 1-Methylcyclopropene on Liver Function in Male Albino Rats

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