2014
DOI: 10.1177/0748233714548207
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Abstract: Pesticides are omnipresent in environment, water, fruits, and vegetables and are considered as risk factors for human health. Consumers are mainly exposed to pesticides through diet, and the main question to be answered concerns the impact of such exposure on health. In this study, we developed a mouse model to mimic consumer exposure. During gestation and lactation periods, the experimental mouse dams (M) received one of the following treatments: (a) diet-free of pesticides; (b) diet enriched with chlorpyrifo… Show more

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Cited by 18 publications
(22 citation statements)
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“…Values of AI exceeding 1.0 may refer to either better improvement or negligible experimental errors. The obtained results are supported by our previously published investigations on other pesticides and different antioxidants [59,64,65].…”
Section: Discussionsupporting
confidence: 89%
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“…Values of AI exceeding 1.0 may refer to either better improvement or negligible experimental errors. The obtained results are supported by our previously published investigations on other pesticides and different antioxidants [59,64,65].…”
Section: Discussionsupporting
confidence: 89%
“…It is worthy to mention that Mansour and Gamet-Payrastre [64] have previously reported that alteration in the levels of biochemical parameters due to pesticide exposure is an indicative to how much deviation than normal values due to this pesticide. This could be determined by calculating the percentage of change in pesticidetreated groups relative to untreated control groups.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…The highly-lipophilic organophosphorus (OPs) compound chlorpyrifos (CPF) is one of the most frequently used non-persistent pesticides worldwide, even though the US Environmental Protection Agency (EPA) banned it from residential use in 2001, and its decreasing use in Europe [65]. It is used extensively because of its effective and cost-competitive broad spectrum of activity, and has often been selected to replace persistent organochlorinated compounds [41]. Nearly everybody present organophosphate residues in their bodies but display no symptomatology [11], so most exposures are below the acute poisoning threshold and are therefore undetected, like a silent pandemic [28].…”
Section: Introductionmentioning
confidence: 99%
“…This raised the interest of scientists to search for antioxidants, which might alleviate oxidative stress caused by pesticides. Several substances including OP pesticides-induced oxidative stress in experimental animals as an essential oil, wheat germ oil and grape seed oil, vitamin E (α-tocopherol) and zinc were used against CPF-induced oxidative stress in rats (Mansour and Mossa 2009;Mansour and Mossa 2010;Khalifa et al,2011;Mansour et al,2011;Mansour and Gamet-Payrstre 2016). The mammalian cells reduced the adverse effect of lipid peroxidation via the utilization of both enzymatic and non-enzymatic antioxidants, which scavenge for free radicals in the system.…”
Section: Introductionmentioning
confidence: 99%