Ameliorative effect of gallic acid in paclitaxel-induced neuropathic pain in mice

Kaur, Satbir; Muthuraman, Arunachalam

doi:10.1016/j.toxrep.2019.06.001

Cited by 40 publications

(22 citation statements)

References 79 publications

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“…For instance, in rat liver mitochondria ex vivo model, GAL prevented bisphenol-induced oxidative damage by inhibiting lipid peroxidation and increasing the content of GSH [ 53 ]. The antioxidant neuro-protective effects of GAL against induced neuropathic pain were also reported in mice [ 54 ], thereby supporting our present data on the antioxidant protective effect of GAL in rat kidney stimulated with DnBP. Additionally, the increased GSH concentration in the kidney of GAL-treated animals allowed for the tolerance of reactive oxygen species, thereby making the tissues potentially resistance to oxidative insult [ 55 ].…”

Section: Discussionsupporting

confidence: 92%

Evaluation of the protective effects of quercetin and gallic acid against oxidative toxicity in rat’s kidney and HEK-293 cells

et al. 2020

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Section: Discussionsupporting

confidence: 92%

Evaluation of the protective effects of quercetin and gallic acid against oxidative toxicity in rat’s kidney and HEK-293 cells

et al. 2020

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“…The CIPN animal model was generated as previously described ( Thangamani et al, 2013 ; Kaur and Muthuraman, 2019 ). Eight- to 10-week old male CD-1 mice were randomized based on body weights and divided into six different groups consisting of six animals each.…”

Section: Methodsmentioning

confidence: 99%

Herbal Decoction Divya-Peedantak-Kwath Alleviates Allodynia and Hyperalgesia in Mice Model of Chemotherapy-Induced Peripheral Neuropathy via Modulation in Cytokine Response

et al. 2020

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The widely used cancer treatment, chemotherapy, causes severe long-term neuropathic pain in 30–40% cases, the condition clinically known as chemotherapy-induced peripheral neuropathy (CIPN). Approved conventional analgesics are sometimes ineffective, while others like opioids have undesirable side effects like addiction, seizures, and respiratory malfunctioning. Tricyclic antidepressants and anticonvulsants, although exhibit anti-allodynic effects in neuropathy, also have unpleasant side effects. Thus, alternative medicines are being explored for CIPN treatment. Despite scattered reports on different extracts from different plants having potential anti-allodynic effects against CIPN, no established medicine or formulation of herbal origin exists. In this study, efficacy of an herbal decoction, formulated based on ancient medicinal principles and protocols for treating neuropathic pain, Divya-Peedantak-Kwath (DPK), has been evaluated in a paclitaxel (PTX)-induced peripheral neuropathic mouse model. We observed that DPK has prominent anti-allodynic and anti-hyperalgesic effects and acts as a nociceptive modulator for CIPN. With exhibited antioxidative effects, DPK restored the redox potential of the sciatic nerves to the normal. On histopathological evaluation, DPK prevented the PTX-induced lesions in the sciatic nerve, in a dose-dependent manner. It also prevented inflammation by modulating the levels of pro-inflammatory cytokines involved in CIPN pathogenesis. Our observations evinced that DPK can alleviate CIPN by attenuating oxidative stress and concomitant neuroinflammation through immune modulation.

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“…Pregablin is anticonvulsant drug that is used in treatment of diabetic and post herpetic neuropathic pain. It binds to presynaptic N type Ca +2 channel at the α 2 δ subunit leading to decrease the release of presynaptic transmitters as substance-P and glutamate (Bansal et al, 2009;Kaur et al, 2019).…”

Section: Issn: 2319-7706 Volume 9 Number 6 (2020)mentioning

confidence: 99%

Effect of Metformin in Rat Model of Vincristine Induced Peripheral Neuropathy

Salem¹,

MandohHedeya²,

Menem³

et al. 2020

Int.J.Curr.Microbiol.App.Sci

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Ameliorative effect of gallic acid in paclitaxel-induced neuropathic pain in mice

Abstract: Graphical abstract

Cited by 40 publications

References 79 publications

Evaluation of the protective effects of quercetin and gallic acid against oxidative toxicity in rat’s kidney and HEK-293 cells

Evaluation of the protective effects of quercetin and gallic acid against oxidative toxicity in rat’s kidney and HEK-293 cells

Herbal Decoction Divya-Peedantak-Kwath Alleviates Allodynia and Hyperalgesia in Mice Model of Chemotherapy-Induced Peripheral Neuropathy via Modulation in Cytokine Response

Effect of Metformin in Rat Model of Vincristine Induced Peripheral Neuropathy

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