Ameliorative effect of berberine on renal damage in rats with diabetes induced by high-fat diet and streptozotocin

Ameliorative Effect and Underlying Mechanisms of Total Triterpenoids from <i>Psidium guajava</i> Linn (Myrtaceae) Leaf on High-Fat Streptozotocin-induced Diabetic Peripheral Neuropathy in Rats

“…The rats were fasted for 12 h prior to injection, rats were injected with STZ (40 mg/kg, dissolved in 0.1 mmol/L sodium citrate buffer, pH 4.5) intraperitoneally, while the control group rats were injected with the vehicle citrate buffer. One week later, the rats with blood glucose above 11.1 mmol/L were considered diabetic and selected for further pharmacological studies [11]; secondly, animals were fed their respective diets until the end of the study as described: diabetic rats were fed with a high -fat diet (consisting of 70 % standard laboratory diet, 15 % carbohydrate, 10 % lard and 5 % yolk powder) while the healthy rats were fed with normal chow. Blood samples obtained from the tail vein of rats were monitored for glucose once a week using reagent strips with a glucometer (Onetouch Ultra 2, Johnson & Johnson, Milpitas, CA, USA).…”

The Hidden Treasure in Europe?s Garden Plants: Case Examples; Berberis darwinni and Berginia cordifolia

“…The other productive area of research on berberine and berberinecontaining plants have been on their potential therapeutic potential for diabetes [36][37][38], and associated diseases such as diabetic neropathy [39] and nephropathy [40,41]. Among the various possible mechanism of berberine's antidiabetic action are through inhibition of peroxisome proliferator-activated receptors expression [42,43] carbohydrate digestion [44], various signalling pathways [45], modulation of protein tyrosine phosphatase 1B activity [46], activation of glucose transport pathway of GLUT-1 [47], promoting the secretion of glucagon-like peptide secretion [48], increasing insulin receptor expression [49], control of lipid dysregulation [50] antioxidant mechanisms and aldose reductase inhibitory activity [51], and anti-inflammatory mechanisms [52].…”

Beneficial Antioxidative Effect of the Homeopathic Preparation of <b><i>Berberis</i></b> <b><i>vulgaris</i></b> in Alleviating Oxidative Stress in Experimental Urolithiasis

“…Administration of berberine has been shown to restore hydrogen peroxide-induced smooth muscle cell injury in rabbit corpus cavenosum [10]. Likewise, the antioxidant and antilipid peroxidation effects of berberine have been related to its renoprotective action in diabetic rats [11] and to the amelioriation of hypertensive renal impairment in rats [12]. Pretreatment with berberine significantly increased superoxide dismutase (SOD) activity in lipopolysaccharide(LPS)-stimulated macrophages and contributed to an overall reduction of intracellular O 2 - [13].…”