Amelioration of Retinal Photic Injury in Albino Rats by Dimethylthiourea

Oxidative Stress-induced Apoptosis in Retinal Photoreceptor Cells Is Mediated by Calpains and Caspases and Blocked by the Oxygen Radical Scavenger CR-6

“…These results are quite interesting since several studies have indicated that the eye is particularly sensitive to oxidative stress and therefore, modifications of the cellular redox state of the eye have been reported to play an important role in retinal degeneration processes (17)(18)(19)(20). Additional support for the involvement of ROS and oxidative stress in photoreceptor apoptosis comes from several studies in which antioxidants appeared to retard or inhibit the degenerative pathology (21)(22)(23). However, the mechanisms of action of these anti-apoptotic molecules are unclear, and further work is necessary to resolve whether oxidative stress acts as a common mediator of retinal degeneration in retinitis pigmentosa.…”

Oxidative Stress-induced Apoptosis in Retinal Photoreceptor Cells Is Mediated by Calpains and Caspases and Blocked by the Oxygen Radical Scavenger CR-6

“…These results are quite interesting since several studies have indicated that the eye is particularly sensitive to oxidative stress and therefore, modifications of the cellular redox state of the eye have been reported to play an important role in retinal degeneration processes (17)(18)(19)(20). Additional support for the involvement of ROS and oxidative stress in photoreceptor apoptosis comes from several studies in which antioxidants appeared to retard or inhibit the degenerative pathology (21)(22)(23). However, the mechanisms of action of these anti-apoptotic molecules are unclear, and further work is necessary to resolve whether oxidative stress acts as a common mediator of retinal degeneration in retinitis pigmentosa.…”

Induction of heme oxygenase 1 in the retina by intense visible light: suppression by the antioxidant dimethylthiourea.

“…Furthermore, ascorbate supplementation reduces the level of retinal light damage in rats (4) as does the synthetic antioxidant DMTU (3,6,7). This suggests, as originally proposed by Noell et al (2), that oxidation occurs in the rat retina in response to prolonged light exposure.…”

Effect of polyphenolic phytochemicals on ectopic oxidative phosphorylation in rod outer segments of bovine retina

“…Further support for the involvement of ROI generation and oxidative stress in photoreceptor apoptosis comes from studies in which antioxidants appear to retard or inhibit the degenerative process (Lam et al ., ; Ranchon et al ., ). Apoptosis seems to be responsible for the cell loss seen in several disorders of the retina, including retinitis pigmentosa (RP), glaucoma and macular degeneration (Dunaief et al ., ; Carella, ) and some protective effects of quercetin were mediated by direct inhibition of the intrinsic apoptosis pathway (Cao et al ., ).…”

Oxidative Stress-induced Apoptosis in Retinal Photoreceptor Cells Is Mediated by Calpains and Caspases and Blocked by the Oxygen Radical Scavenger CR-6

“…These results are quite interesting since several studies have indicated that the eye is particularly sensitive to oxidative stress and therefore, modifications of the cellular redox state of the eye have been reported to play an important role in retinal degeneration processes (17)(18)(19)(20). Additional support for the involvement of ROS and oxidative stress in photoreceptor apoptosis comes from several studies in which antioxidants appeared to retard or inhibit the degenerative pathology (21)(22)(23). However, the mechanisms of action of these anti-apoptotic molecules are unclear, and further work is necessary to resolve whether oxidative stress acts as a common mediator of retinal degeneration in retinitis pigmentosa.…”

Induction of heme oxygenase 1 in the retina by intense visible light: suppression by the antioxidant dimethylthiourea.

“…Furthermore, ascorbate supplementation reduces the level of retinal light damage in rats (4) as does the synthetic antioxidant DMTU (3,6,7). This suggests, as originally proposed by Noell et al (2), that oxidation occurs in the rat retina in response to prolonged light exposure.…”

Effect of polyphenolic phytochemicals on ectopic oxidative phosphorylation in rod outer segments of bovine retina

“…Further support for the involvement of ROI generation and oxidative stress in photoreceptor apoptosis comes from studies in which antioxidants appear to retard or inhibit the degenerative process (Lam et al ., ; Ranchon et al ., ). Apoptosis seems to be responsible for the cell loss seen in several disorders of the retina, including retinitis pigmentosa (RP), glaucoma and macular degeneration (Dunaief et al ., ; Carella, ) and some protective effects of quercetin were mediated by direct inhibition of the intrinsic apoptosis pathway (Cao et al ., ).…”

Oxidative Stress-induced Apoptosis in Retinal Photoreceptor Cells Is Mediated by Calpains and Caspases and Blocked by the Oxygen Radical Scavenger CR-6

“…These results are quite interesting since several studies have indicated that the eye is particularly sensitive to oxidative stress and therefore, modifications of the cellular redox state of the eye have been reported to play an important role in retinal degeneration processes (17)(18)(19)(20). Additional support for the involvement of ROS and oxidative stress in photoreceptor apoptosis comes from several studies in which antioxidants appeared to retard or inhibit the degenerative pathology (21)(22)(23). However, the mechanisms of action of these anti-apoptotic molecules are unclear, and further work is necessary to resolve whether oxidative stress acts as a common mediator of retinal degeneration in retinitis pigmentosa.…”

Induction of heme oxygenase 1 in the retina by intense visible light: suppression by the antioxidant dimethylthiourea.

“…Furthermore, ascorbate supplementation reduces the level of retinal light damage in rats (4) as does the synthetic antioxidant DMTU (3,6,7). This suggests, as originally proposed by Noell et al (2), that oxidation occurs in the rat retina in response to prolonged light exposure.…”

Effect of polyphenolic phytochemicals on ectopic oxidative phosphorylation in rod outer segments of bovine retina

“…Further support for the involvement of ROI generation and oxidative stress in photoreceptor apoptosis comes from studies in which antioxidants appear to retard or inhibit the degenerative process (Lam et al ., ; Ranchon et al ., ). Apoptosis seems to be responsible for the cell loss seen in several disorders of the retina, including retinitis pigmentosa (RP), glaucoma and macular degeneration (Dunaief et al ., ; Carella, ) and some protective effects of quercetin were mediated by direct inhibition of the intrinsic apoptosis pathway (Cao et al ., ).…”