Amelioration of Nicotine-Induced Damage of Blood Cells in Protein Malnourished Female Rats by Curcumin

Banerjee, Satyam; Bandyopadhyaya, Gargi; Chattopadhyay, Kalicharan; Chattopadhyay, Brajadulal

doi:10.3923/ijp.2010.444.455

Cited by 15 publications

(7 citation statements)

References 19 publications

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“…(1957). Serum uric acid was measured in the serum by the method described of Barham and Trinder (1972) and Fossati et al (1980), whereas serum urea nitrogen was determined in the serum based on Patton and Crouch (1977). Serum creatinine forms colored complex when reacting with alkaline Picrate.…”

Section: Biochemical Analysismentioning

confidence: 99%

“…As well, Ozukutat et al (2005) stated that nicotine promotes the oxidative stress in both of Vivo and Vitro. Previous studies revealed that the ability of nicotine to bind to DNA, which causes significantly higher effects of genotoxic in protein-restricted conditions (Bandyopadhyaya et al, 2008 andBanerjee et al, 2010). Nicotine also increases the release of free fatty acids from the liver, as well as the hepatic creation of very-lowdensity lipoproteins (El-Sokkary et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

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Nutritional value of germinated quinoa seeds and their protective effects on rats' health injected by nicotine

Ali

2019

Egypt. J. Food Sci.

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N ICOTINE resulted from heavy smoking raises the risk of developing of chronic liver diseases, hence hepatocellular carcinoma. Nicotine also encourages the proinflammatory cytokins production which would be involved in the injury of liver cell. This study was conducted to investigate nutritional components and protective effect of germinated quinoa seeds on rats' health that injected by nicotine. Thirty male albino adult rats (150±10 g.) were used. The rats divided into two main groups; one used as a negative control group fed on basal diet, while other groups used as a positive control group fed on basal diet also and three other rats subgroups fed on supplemented diet with germinated quinoa seeds at three concentrations (i.e. 5 %, 10% and 15%) for 4 weeks, then injected with nicotine subcutaneously for 15 days. Biological evaluation, lipid profile, liver enzymes, kidney functions, and antioxidant markers were estimated at the end of the experiment. The chemical composition of germinated quinoa seeds demonstrated that quinoa can be considered as a good source for dietary fiber, polyphenols and other antioxidant compounds which raised the nutritional value. The results indicated that kidney and liver functions were restored significantly in rats' groups received quinoa seeds 10%, followed by quinoa seeds 5 % as compared to the positive control group. The nicotine rats group showed significant decrease in triglyceride, VLDL-C, and LDL-C; on the other hand, all supplemented groups with quinoa seeds 10%, followed by quinoa seeds 5 % showed a gradually significant increase in HDL-C. Serum total cholesterol and LDL-C were significantly increased in the positive control group, while they gradually significant decreased in all supplemented diet groups demonstrated. Therefore, this study reveals the health benefits of quinoa seeds in functional foods for heart disease, hypercholesterolemic and patients with liver disease.

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Section: Biochemical Analysismentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Nutritional value of germinated quinoa seeds and their protective effects on rats' health injected by nicotine

Ali

2019

Egypt. J. Food Sci.

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“…Previously, it was noticed that curcumin effectively ameliorated the nicotine decrement of haemoglobin concentration in the blood and total protein concentration in the serum of nicotineinduced rat [8,20]. This study similarly has established that raw turmeric rhizomes are very much useful in maintaining the levels of blood haemoglobin concentration and total serum protein concentration of the workers against nicotine exposure.…”

Section: Discussionmentioning

confidence: 65%

“…Tobacco smoke increases the formation of reactive oxygen species (ROS) and toxic chemical loads consequently increases cardiovascular as well as other circulatory diseases [6]. Nicotine also aggravates DNA single strand break resulting in the higher percentage of DNA damage under protein-restricted condition [7,8]. It is a risk factor for oral cancer [9], periodontal disease [10] and osteoporosis [11].…”

Section: Introductionmentioning

confidence: 99%

Protective Role of Raw-Turmeric Rhizomes Against Nicotine-Induced Complications of Beedi (Indian Cigarette) Workers

Chattopadhyay¹

2015

Pharm Anal Acta

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Introduction: The unscientific process of beedi (Indian smoking element) production under constant exposure of nicotine dust in India induces serious health disorders to the workers. Beedi produces more tar in smoke than cigarette due to lack of any filtering process. Sometimes active consumption of beedi and other tobacco products makes the users more vulnerable to cancer, respiratory diseases and cardiovascular disorders etc.Objective: The present study was designed to observe the protective effects of raw turmeric rhizomes on health conditions of the beedi workers who were exposed to nicotine dust for 8-10 hours daily for a long duration.Methods: General health checkup, blood glucose levels, lipid profiles and the hemogram profiles etc. of the workers from two beedi factories (Canning of South 24 Parganas District and Bankura of Bankura District, both in West Bengal, India) were conducted before and after the consumption of laboratory processed raw turmeric rhizomes (80 mg/kg body weight/day by chewing) for 8 weeks. Blood samples (5 ml) were collected from all the workers before and after the completion of the study and analyzed for estimation of different parameters. Results:The results showed significant improvement in the general health conditions of the factory workers who consumed raw-turmeric rhizomes. Significant improvement of blood pressure, blood glucose levels and lipid profiles and also improvement of creatinine, serum protein and SGOT/SGPT levels of the treated volunteers were noted. The results also showed improvement in the enzymes levels of SOD, GSH and GP X in the serum of rhizomes consumed workers. Conclusion:It is concluded that turmeric rhizomes are effective in the amelioration of nicotine-induced complications. It would be a better therapeutic supplement for the improvement of health for the workers who are compelled to work under nicotinic dust environment for a long time.

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“…This increase in the total chlorophyll content can be attributed to the ability of curcumin to interact with DNA and mediate the transient increase in expression of enzymes of the C5 pathway for chlorophyll synthesis [35]. Such effect of curcumin may be due to its potentiality to act as antioxidant as reported elsewhere in animal cells [36]- [39]. The effect of arsenic on germination and growth of growing mung bean [Vigna radiata (L.) Wilezek] is found to be inhibitory, which is in consistent with earlier reports in mung bean [25] and in other plants.…”

Section: Effect Of Curcumin and Its Interaction With As On Photosynthmentioning

confidence: 95%

Arsenic Induced Changes in Growth and Physiological Responses in <i>Vigna radiata</i> Seedling: Effect of Curcumin Interaction

Upadhyaya¹,

Shome²,

Roy³

et al. 2014

AJPS

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Arsenic is a great hazard to the environment since it is a major source of soil and water contamination leading to phytotoxicity. Arsenic caused reduction in seed germination and growth of plants including mung bean (Vigna radiata) causing loss of crop productivity. This investigation evaluates effect of arsenic toxicity in mung bean with an attempt to ameliorate it by the application of curcumin. Arsenic induced reduction in fresh, dry mass, length of root and shoot and pigment content. The result of the present study suggests that curcumin at lower concentration ameliorates arsenic induced toxicity in Vigna radiata.

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Amelioration of Nicotine-Induced Damage of Blood Cells in Protein Malnourished Female Rats by Curcumin

Cited by 15 publications

References 19 publications

Nutritional value of germinated quinoa seeds and their protective effects on rats' health injected by nicotine

Nutritional value of germinated quinoa seeds and their protective effects on rats' health injected by nicotine

Protective Role of Raw-Turmeric Rhizomes Against Nicotine-Induced Complications of Beedi (Indian Cigarette) Workers

Arsenic Induced Changes in Growth and Physiological Responses in <i>Vigna radiata</i> Seedling: Effect of Curcumin Interaction

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Amelioration of Nicotine-Induced Damage of Blood Cells in Protein Malnourished Female Rats by Curcumin

Cited by 15 publications

References 19 publications

Nutritional value of germinated quinoa seeds and their protective effects on rats' health injected by nicotine

Nutritional value of germinated quinoa seeds and their protective effects on rats' health injected by nicotine

Protective Role of Raw-Turmeric Rhizomes Against Nicotine-Induced Complications of Beedi (Indian Cigarette) Workers

Arsenic Induced Changes in Growth and Physiological Responses in &lt;i&gt;Vigna radiata&lt;/i&gt; Seedling: Effect of Curcumin Interaction

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Arsenic Induced Changes in Growth and Physiological Responses in <i>Vigna radiata</i> Seedling: Effect of Curcumin Interaction