Amelioration of acute myocardial infarction by saponins from flower buds of Panax notoginseng via pro-angiogenesis and anti-apoptosis

Yang, Bin; Cheung, Kwok-Kuen; Zhou, Xin; Xie, Rui Fang; Cheng, Pei Pei; Wu, Shan; Zhou, Zhong Yan; Tang, Jing; Hoi, Maggie Pui Man; Wang, You Hua; Lee, Simon Ming‐Yuen

doi:10.1016/j.jep.2016.01.022

Cited by 57 publications

(30 citation statements)

References 44 publications

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“…Modern pharmacological studies show that the active ingredients of Codonopsis pilosula play a very important role in treatment of cardiovascular system diseases and can attenuate calcium influx and apoptosis induced by angiotensin II plus Leu (27) insulin-like growth factor II in H9c2 cardiomyoblasts [49]. Several studies have reported that Panax notoginseng has many cardiovascular protective effects, including proangiogenesis, antiapoptosis, decreasing oxidative stress, repressing inflammatory cascade, and endothelium-dependent vasodilation effects [50–52]. The volatile oil of Nardostachyos Radix et Rhizoma can inhibit oxidative stress-induced cell death via reactive oxygen species scavenging and Akt activation in H9c2 cardiomyocyte [53].…”

Section: Discussionmentioning

confidence: 99%

Effect of Wenxin Granules on Gap Junction and MiR-1 in Rats with Myocardial Infarction

Zhao

Lou

et al. 2017

BioMed Research International

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Myocardial infarction (MI) patients are at high risk of potential lethal arrhythmia. Gap junction and microRNA-1 (miR-1) are both arrhythmia generating conditions. The present study investigated whether Wenxin Granules (Wenxin-Keli, WXKL) could prevent potential lethal arrhythmia by improving gap junctions and miR-1 following MI. Male Sprague-Dawley rats were divided randomly into control, model, metoprolol, low dose WXKL, and high dose WXKL groups. The MI rat model was created by coronary artery ligation. Treatments were administrated intragastrically to the rats for 4 weeks. Conventional transmission electron microscopy was performed to observe the ultrastructure of gap junctions. Quantitative real-time PCR and western blotting were used to detect the expression of miR-1, protein kinase C (PKC), and related proteins. Additionally, a programmatic electrophysiological stimulation test was performed to detect the ventricular fibrillation threshold (VFT). WXKL protected the ultrastructure of the gap junctions and their constituent Cx43 by regulating miR-1 and PKC mediated signal transduction and increased the VFT significantly in the rat MI model. The results suggested that WXKL is an effective alternative medicine to prevent potentially lethal arrhythmia following MI.

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Section: Discussionmentioning

confidence: 99%

Effect of Wenxin Granules on Gap Junction and MiR-1 in Rats with Myocardial Infarction

Zhao

Lou

et al. 2017

BioMed Research International

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“…Panax Notoginseng Saponins (PNS) is the active ingredient of the Chinese herb Sanqui, which is predominantly cultivated in the Yunnan and Guangxi provinces of China (8). The medicinal properties of the Panax Notoginseng root include relieving swelling, promoting blood clotting and alleviating pain (9). It has been reported that PNS has a number of biological activities including immunomodulatory effects, antioxidation and anticancer properties (10).…”

Section: Introductionmentioning

confidence: 99%

Panax Notoginseng Saponins attenuates sevoflurane-induced nerve cell injury by modulating AKT signaling pathway

Yang

Sun

Chen

et al. 2017

Molecular Medicine Reports

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General anesthesia in patients with or at risk for neuronal injury remains challenging due to the neurotoxic effects of volatile anesthetics. One inhalation anesthetic, sevoflurane, induces neuronal damage, including neuroapoptosis, and learning and memory impairment. Panax Notoginseng Saponins (PNS) is the active ingredient of Sanqui and has been reported to exert neuroprotective effects. In the current study, the protective effect of PNS on sevoflurane‑induced nerve cell injury was explored. Cell proliferation was significantly reduced in a dose‑dependent manner following stimulation with sevoflurane. Furthermore, cell apoptosis and the protein expression of caspase‑3, caspase‑9 and Bax were significantly increased, while the expression of Bcl‑2 was decreased in the sevoflurane group compared with normal control. Furthermore, the protein level of Bace‑1, APP and Aβ were elevated in the sevoflurane group compared with the control group. By contrast, PNS treatment significantly reduced the neurotoxicity induced by sevoflurane. Additionally, sevoflurane reduced activation of the AKT signaling pathway, which was activated by PNS treatment. In conclusion, the results suggested that PNS attenuates sevoflurane‑induced neurotoxicity through by stimulating cell proliferation and inhibiting cell apoptosis. These effects were mediated, at least in part, by activating the AKT signaling pathway.

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“…infarction [12]. PNF contains the highest abundance of saponins among the different parts of P. notoginseng [13,14], but the saponin composition of flower is distinctly different to the roots [15].…”

Section: Introductionmentioning

confidence: 99%

Comparative study on chemical components and anti‐inflammatory effects of Panax notoginseng flower extracted by water and methanol

Liu

Zhong

et al. 2017

J of Separation Science

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Methanol and water are commonly used solvents for chemical analysis and traditional decoction, respectively. In the present study, a high-performance liquid chromatography with ultraviolet detection method was developed to quantify 11 saponins in Panax notoginseng flower extracted by aqueous solution and methanol, and chemical components and anti-inflammatory effects of these two extracts were compared. The separation of 11 saponins, including notoginsenoside Fc and ginsenoside Rc, was well achieved on a Zorbax SB C18 column. This developed method provides an adequate linearity (r > 0.999), repeatability (RSD < 4.26%), inter- and intraday variations (RSD < 3.20%) with recovery (94.7-104.1%) of 11 saponins concerned. Our data indicated that ginsenoside biotransformation in PNF was found, when water was used as the extraction solvent, but not methanol. Specifically, the major components of Panax notoginseng flower, ginsenosides Rb1, Rc, Rb2, Rb3, and Rd, can be near completely transformed to the minor components, gypenoside XVII, notoginsenoside Fe, ginsenoside Rd2, notoginsenoside Fd, and ginsenoside F2, respectively. Total protein isolated from Panax notoginseng flower is responsible for this ginsenoside biotransformation. Additionally, methanol extract exerted the stronger anti-inflammatory effects than water extract in lipopolysaccharide-induced RAW264.7 cells. This difference in anti-inflammatory action might be attributed to their chemical difference of saponins.

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Amelioration of acute myocardial infarction by saponins from flower buds of Panax notoginseng via pro-angiogenesis and anti-apoptosis

Cited by 57 publications

References 44 publications

Effect of Wenxin Granules on Gap Junction and MiR-1 in Rats with Myocardial Infarction

Effect of Wenxin Granules on Gap Junction and MiR-1 in Rats with Myocardial Infarction

Panax Notoginseng Saponins attenuates sevoflurane-induced nerve cell injury by modulating AKT signaling pathway

Comparative study on chemical components and anti‐inflammatory effects of Panax notoginseng flower extracted by water and methanol

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