Ameliorating Impact of Phoenix dactylifera L. Leaves Oil Extract on Testicular Toxicity Induced by Gibberellic Acid: Histomorphometric and Immunohistochemical Studies

Ahmed, Rania A.; Nofal, Amany E.

doi:10.21608/ejh.2020.23396.1250

Cited by 3 publications

(3 citation statements)

References 41 publications

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“…reported that oral fisetin administration as a strawberry flavonol revealed resistance to chronic airway disease in mice. Polyphenol agents, such as those in date palm, have been shown to significantly ameliorate cytotoxicity by improving antioxidant and immunity alterations in rat testes ( 47 , 48 ).…”

Section: Discussionmentioning

confidence: 99%

Immunostimulatory and anti-inflammatory impact of Fragaria ananassa methanol extract in a rat model of cadmium chloride-induced pulmonary toxicity

Nofal,

AboShabaan,

Fayyad

et al. 2023

Front. Immunol.

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Cadmium is an extremely dangerous heavy metal that can lead to disastrous consequences in all organisms. Several natural remedies reduce the toxicities of experimentally generated metals in animals. Strawberry Fragaria ananassa contains several bioactive compounds that may mitigate heavy-metal toxicity. The study aim was to evaluate the ability of a strawberry fruit methanol extract (SE) to reduce Cd toxicity and to identify and quantify the active constituents of SE. Forty Wistar rats were classified into four groups: the control group– 1 ml saline IP; SE group– 100 mg of SE/kg rats orally; cadmium (Cd) group–2 mg CdCl2/kg body weight/IP daily; and treated group– SE given 1 hour before Cd administration. Administration of Cd induced several histopathological and immunohistochemical alterations in lung sections. Biochemical analysis of lung homogenates and mRNA levels of antioxidants and inflammatory cytokines indicated significant changes to the risk profile. SE administration significantly decreased the oxidative stress, inflammation, tissue damage, the mean area percentage of collagen fibers, and positive immuno-expressions of TNF-α and NF-κB induced by CdCl2. Moreover, the MDA, TNF-α, GM-CSF, and IL-1β levels in Cd-exposed rat lung tissue were significantly lower in the SE-treated group than in the Cd-group. SE significantly augmented lung GSH, SOD, HO‐1, GPx-2, and Nrf2 levels in Cd-exposed rats. SE mitigated Cd-caused oxidative stress and lung inflammation. Therefore, regularly consuming a strawberry-rich diet could benefit general health and help prevent and treat diseases.

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Section: Discussionmentioning

confidence: 99%

Immunostimulatory and anti-inflammatory impact of Fragaria ananassa methanol extract in a rat model of cadmium chloride-induced pulmonary toxicity

Nofal,

AboShabaan,

Fayyad

et al. 2023

Front. Immunol.

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“…Palma Soto, J. A., Parra Acosta, H., & Orduño Cruz, N. Análisis del ácido giberélico desde la cartografía conceptual con enfoque bioético y sustentable | 1-18 Sin embargo, estudios recientes demuestran que el consumo de frutas y verduras tratadas con ácido giberélico induce, en humanos y animales, al estrés oxidativo, alteraciones patológicas del cerebro, pulmón, bazo, estómago, hígado, aparato reproductor y al desarrollo de efectos genotóxicos y cancerígenos (Ahmed & Nofal, 2021).…”

Section: Issn Online 2007-9621unclassified

Análisis del ácido giberélico desde la cartografía conceptual con enfoque bioético y sustentable

Soto¹,

Acosta²,

Orduño-Cruz³

2022

Acta Universitaria

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El ácido giberélico permite el aumento del rendimiento, el control de diferentes etapas del desarrollo y el estrés abiótico en cultivos. Diversas investigaciones sugieren que la exposición de animales de laboratorio al ácido giberélico podría estar asociada al mal funcionamiento de órganos. El objetivo de este trabajo fue identificar, desde la bioética y la sustentabilidad, los beneficios y perjuicios del uso del ácido giberélico mediante la cartografía conceptual y la socioformación. Para ello, se desarrollaron los ocho ejes de la cartografía conceptual. Se encontró que existe interés en la producción y aplicación sustentable del ácido giberélico; sin embargo, no se atiende a los principios de la bióetica. Por esta razón, se concluyó que el enfoque bioético y sustentable en el uso del ácido giberélico debe introducirse desde la formación de los profesionales del campo para generar conocimientos que ayuden a desarrollar formulaciones eficientes y selectivas.

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“…However, previous studies have determined that GA 3 is not exempt of toxicity. The hematotoxicity of GA 3 has been studied using animal models such as rats and mice (Tuluce and Çelik 2006;Muthu et al 2011;Troudi et al 2012a;Ali et al 2021Ali et al , 2022Ahmed and Nofal 2021;Galal et al 2021;Soliman et al 2021aSoliman et al , b, 2022aBushra and Shenouda 2022), hens and quail hens (Elsebai et al 2003b;Elkomy et al 2008;Ismail 2009), and rabbits (El-Sebai 2004). Nevertheless, the impacts of GA 3 on the hematological parameters and erythron profile of fish have not been investigated (Sayed et al 2020).…”

Section: Introductionmentioning

confidence: 99%

The mitigating effect of Spirulina (Arthrospira platensis) on the hemotoxicity of gibberellic acid on juvenile tilapia (Oreochromis niloticus)

Sayed

Hamed

El-Sayed

et al. 2022

Environ Sci Pollut Res

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The use of plant growth regulators has led to environmental contamination of water bodies that occur adjacent to agricultural areas. Some of these chemicals are bioactive, not only to plants, but also to non-target exposed biota, namely of the aquatic compartment. Previous work demonstrated the establishment of hepato- and nephrotoxic effects in juvenile tilapia (Oreochromis niloticus) exposed via aquatic media to gibberellic acid (GA3), which is among the most used plant growth regulators, in agricultural practices. Here, we investigated the effect of GA3 on hematological indices, poikilocytosis, nuclear abnormalities, and genotoxic indices measured in Nile tilapia (Oreochromis niloticus), as well as the putative protective effects of dietary supplementation of Spirulina (Arthrospira platensis). Fish were evenly assorted into 5 groups: group I served as a control, and groups II–V were fed diets supplemented with Spirulina at rates of 0 g/kg, 5 g/kg, 20 g/kg, and 100 g/kg, respectively, for 2 months before being exposed to 150 mg/L GA3. The results revealed that GA3 exposure decreased significantly all hematological indices (P < 0.05), except leucocytes and mean corpuscular hemoglobin concentration (MCHC), compared to the control group (P > 0.05). GA3 exposure increased significantly the percentage of nuclear abnormalities, altered erythrocytes and the percentages of tail DNA, compared to the control group (P < 0.05). Spirulina supplementation restored the hematological, poikilocytosis, nuclear abnormalities, and the percentages of tail DNA to near normal levels. The 100 g/kg SP treatment was the most effective in attaining such effect, showing concentration-dependency. The present study reinforces our findings of the toxicity of GA3 on O. niloticus and suggests that the addition of Spirulina to fish diet can mitigate the hemotoxic effects of GA3.

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Ameliorating Impact of Phoenix dactylifera L. Leaves Oil Extract on Testicular Toxicity Induced by Gibberellic Acid: Histomorphometric and Immunohistochemical Studies

Cited by 3 publications

References 41 publications

Immunostimulatory and anti-inflammatory impact of Fragaria ananassa methanol extract in a rat model of cadmium chloride-induced pulmonary toxicity

Immunostimulatory and anti-inflammatory impact of Fragaria ananassa methanol extract in a rat model of cadmium chloride-induced pulmonary toxicity

Análisis del ácido giberélico desde la cartografía conceptual con enfoque bioético y sustentable

The mitigating effect of Spirulina (Arthrospira platensis) on the hemotoxicity of gibberellic acid on juvenile tilapia (Oreochromis niloticus)

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