Ambient temperature reduction extends lifespan via activating cellular degradation activity in an annual fish (Nothobranchius rachovii)

Lu, Cheng-Yen; Hsu, Chin-Yuan

doi:10.1007/s11357-015-9775-z

Cited by 15 publications

(7 citation statements)

References 48 publications

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“…These CSPs could mediate certain protective effects of cooling during neurodegeneration and aging (Peretti et al 2015). Low temperatures can also stimulate the proteasome degradation pathway in fish, which may contribute to longevity (Lu and Hsu 2015). It is unclear how CSPs and the proteasome pathway are turned on by low temperatures.…”

Section: Temperature and Longevitymentioning

confidence: 99%

Thermosensation and longevity

Xiao

Liu

2015

J Comp Physiol A

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Temperature has profound effects on behavior and aging in both poikilotherms and homeotherms. To thrive under the ever fluctuating environmental temperatures, animals have evolved sophisticated mechanisms to sense and adapt to temperature changes. Animals sense temperature through various molecular thermosensors, such as thermosensitive TRP channels expressed in neurons, keratinocytes, and intestine. These evolutionarily conserved thermosensitive TRP channels feature distinct activation thresholds, thereby covering a wide spectrum of ambient temperature. Temperature changes trigger complex thermosensory behaviors. Due to the simplicity of the nervous system in model organisms such as C. elegans and Drosophila, the mechanisms of thermosensory behaviors in these species have been extensively studied at the circuit and molecular levels. While much is known about temperature regulation of behavior, it remains largely unclear how temperature affects aging. Recent studies in C. elegans demonstrate that temperature modulation of longevity is not simply a passive thermodynamic phenomenon as suggested by the rate-of-living theory, but rather a process that is actively regulated by genes, including those encoding thermosensitive TRP channels. In this review, we discuss our current understanding of thermosensation and its role in aging.

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Section: Temperature and Longevitymentioning

confidence: 99%

Thermosensation and longevity

Xiao

Liu

2015

J Comp Physiol A

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“…The core can be flanked by either one or two regulatory particles, RPs or 19S, which are responsible for the recognition and unfolding of polyubiquitinated proteins (Finley et al 2016). In the killifish species Nothobranchius rachovii, a linear inverse correlation is seen in muscle tissue between proteasome activity and ambient temperature, without a detectable change in proteasome amount (Lu and Hsu 2015). Also, raising the room temperature of mice housed at 22 to 30°C decreases in vitro measured proteasome activity from brown adipose tissue (Bartelt et al 2018).…”

Section: Introductionmentioning

confidence: 99%

Tissue-specific effects of temperature on proteasome function

Pispa

Matilainen

Holmberg

2020

Cell Stress and Chaperones

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Variation in ambient growth temperature can cause changes in normal animal physiology and cellular functions such as control of protein homeostasis. A key mechanism for maintaining proteostasis is the selective degradation of polyubiquitinated proteins, mediated by the ubiquitin-proteasome system (UPS). It is still largely unsolved how temperature changes affect the UPS at the organismal level. Caenorhabditis elegans nematodes are normally bred at 20 °C, but for some experimental conditions, 25 °C is often used. We studied the effect of 25 °C on C. elegans UPS by measuring proteasome activity and polyubiquitinated proteins both in vitro in whole animal lysates and in vivo in tissue-specific transgenic reporter strains. Our results show that an ambient temperature shift from 20 to 25 °C increases the UPS activity in the intestine, but not in the body wall muscle tissue, where a concomitant accumulation of polyubiquitinated proteins occurs. These changes in the UPS activity and levels of polyubiquitinated proteins were not detectable in whole animal lysates. The exposure of transgenic animals to 25 °C also induced ER stress reporter fluorescence, but not the fluorescence of a heat shock responsive reporter, albeit detection of a mild induction in hsp-16.2 mRNA levels. In conclusion, C. elegans exhibits tissue-specific responses of the UPS as an organismal strategy to cope with a rise in ambient temperature.

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“…These findings are consistent with a report by Lu and Hsu, who found that a reduction in ambient temperature extends the lifespan of N. rachovii. Mechanistically, this effect was probably linked with an improvement in cellular degradation pathways, as evidenced by increased 20S proteasome activity, decreased levels of polyubiquitin aggregates, and increased expression of the macroautophagy indicator microtubule-associated protein 1 light chain 3 (LC3) [ 105 ]. Another intriguing factor affecting the lifespan of N. furzeri appeared to be the gut microbiota.…”

Section: Aging In the Fish Of The Genus Nothobranchiusmentioning

confidence: 99%

Nontraditional systems in aging research: an update

Mikuła-Pietrasik

Pakuła

Markowska

et al. 2020

Cell. Mol. Life Sci.

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Research on the evolutionary and mechanistic aspects of aging and longevity has a reductionist nature, as the majority of knowledge originates from experiments on a relatively small number of systems and species. Good examples are the studies on the cellular, molecular, and genetic attributes of aging (senescence) that are primarily based on a narrow group of somatic cells, especially fibroblasts. Research on aging and/or longevity at the organismal level is dominated, in turn, by experiments on Drosophila melanogaster, worms (Caenorhabditis elegans), yeast (Saccharomyces cerevisiae), and higher organisms such as mice and humans. Other systems of aging, though numerous, constitute the minority. In this review, we collected and discussed a plethora of up-to-date findings about studies of aging, longevity, and sometimes even immortality in several valuable but less frequently used systems, including bacteria (Caulobacter crescentus, Escherichia coli), invertebrates (Turritopsis dohrnii, Hydra sp., Arctica islandica), fishes (Nothobranchius sp., Greenland shark), reptiles (giant tortoise), mammals (blind mole rats, naked mole rats, bats, elephants, killer whale), and even 3D organoids, to prove that they offer biogerontologists as much as the more conventional tools. At the same time, the diversified knowledge gained owing to research on those species may help to reconsider aging from a broader perspective, which should translate into a better understanding of this tremendously complex and clearly system-specific phenomenon.

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Ambient temperature reduction extends lifespan via activating cellular degradation activity in an annual fish (Nothobranchius rachovii)

Cited by 15 publications

References 48 publications

Thermosensation and longevity

Thermosensation and longevity

Tissue-specific effects of temperature on proteasome function

Nontraditional systems in aging research: an update

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