Ambient Pollution and Heart Rate Variability

Gold, Diane R.; Litonjua, Augusto A.; Schwartz, Joel; Lovett, Eric G.; Larson, Andrew C.; Nearing, Bruce D.; Allen, George; Verrier, Monique; Cherry, Rebecca C.; Verrier, Richard L.

doi:10.1161/01.cir.101.11.1267

Cited by 781 publications

(548 citation statements)

References 16 publications

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“…These studies have found that the elderly with or without cardiovascular conditions, hypertension or diabetes may be more responsive to airborne particle exposure and have a larger reduction of the HRV in relation to an increase in PM 2.5 ambient concentrations (Liao et al, 1999;Pope et al, 1999Pope et al, , 2004bGold et al, 2000;Holguı´n et al, 2003). Our findings are consistent with those even though we studied young healthy adults; as expected, the magnitude of association was larger in those studies where susceptible individuals were included than in ours.…”

Section: Discussionsupporting

confidence: 92%

“…One included seven participants and involved monitoring only PM 10 (Pope et al, 1999). Another study estimated the effect of average levels of PM 2.5 and ozone over the previous 4 h on SDNN and rMSSD (Gold et al, 2000), and a study in Utah that included 88 participants examined PM's influence on cardiac autonomic function as measured by HRV (SDNN and rMSSD) and blood markers of inflammation (Pope et al, 2004 b). All of them found that an increase in PM 2.5 or in PM 10 , alone or combined with other pollutants like ozone, were associated with a reduction of the SDNN and of the rMSSD, only one study informed an increase of this last index (Gold et al, 2000).…”

Section: Discussionmentioning

confidence: 99%

“…Another study estimated the effect of average levels of PM 2.5 and ozone over the previous 4 h on SDNN and rMSSD (Gold et al, 2000), and a study in Utah that included 88 participants examined PM's influence on cardiac autonomic function as measured by HRV (SDNN and rMSSD) and blood markers of inflammation (Pope et al, 2004 b). All of them found that an increase in PM 2.5 or in PM 10 , alone or combined with other pollutants like ozone, were associated with a reduction of the SDNN and of the rMSSD, only one study informed an increase of this last index (Gold et al, 2000). Studies in which frequency domain indexes were used also found this association, particularly of the HF of a parasympathetic-related index (Liao et al, 1999;Holguı´n et al, 2003;Park et al, 2005).…”

Section: Discussionmentioning

confidence: 99%

“…Most air pollution research has measured the exposure with fix monitors, in some cases data were taken from the environmental monitor network, which is known to be a good estimate but may be altered by weather conditions such as wind, rain or RH (Pope et al, 1999, Gold et al, 2000, Park et al, 2005. Other studies have used fixed indoor monitors (Liao et al, 1999;Holguı´n et al, 2003).…”

Section: Discussionmentioning

confidence: 99%

“…Recent studies that included elderly individuals with heart diseases in Baltimore, Boston and Mexico City suggest that PM 2.5 air pollution measured with ambient monitors was associated with a reduced HRV (Liao et al, 1999;Gold et al, 2000;Holguı´n et al, 2003;Park et al, 2005). The aim of this study was to test whether this association could also be observed in young healthy adults, using personal exposure monitors, at ambient levels currently observed in the Mexico City metropolitan area (MCMA).…”

Section: Introductionmentioning

confidence: 96%

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Ambient fine particles modify heart rate variability in young healthy adults

Vallejo

Ruiz

Hermosillo

et al. 2005

J Expo Sci Environ Epidemiol

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Particulate air pollution has been related with cardiopulmonary morbidity and mortality. Recent studies have shown that an increase in particulate matter (PM) 2.5 ambient concentrations was associated with a decrease in heart rate variability (HRV) in the elderly with cardiovascular conditions, which could increase the risk of death. In order to assess if this association could also be observed in young adults, we studied 40 young healthy residents of the Mexico City Metropolitan Area (MCMA) who underwent 13 h Holter electrocardiographic and PM 2.5 personal monitoring. HRV was evaluated in time domain: the standard deviation of normal RR intervals (SDNN) and the percentage of differences between adjacent normal RR intervals larger than 50 ms (pNN50). In multivariate analysis with mixed effects models, a significant negative association of pNN50 with PM 2.5 accumulative exposure was found. An increase in 30 mg/m 3 of the average PM 2.5 personal exposure in the previous 2 h decreased the pNN50 in 0.08% (P ¼ 0.01). This observation revealed an acute effect related to environmental exposure to PM 2.5 with regard to HRV in normal youngsters. The long-term health consequences of this association in young healthy adults remain to be clarified.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 96%

See 3 more Smart Citations

Ambient fine particles modify heart rate variability in young healthy adults

Vallejo

Ruiz

Hermosillo

et al. 2005

J Expo Sci Environ Epidemiol

View full text Add to dashboard Cite

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Ambient Air Pollution and the Risk of Acute Ischemic Stroke

Wellenius

Burger²,

Coull³

et al. 2012

Arch Intern Med

303

245

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Background The link between daily changes in ambient fine particulate matter air pollution (PM2.5) and cardiovascular morbidity and mortality is well established. Whether PM2.5 at levels below current US National Ambient Air Quality Standards also increases the risk of ischemic stroke remains uncertain. Methods We reviewed the medical records of 1705 Boston-area patients hospitalized with neurologist-confirmed ischemic stroke and abstracted data on the time of symptom onset and clinical characteristics. PM2.5 concentrations were measured at a central monitoring station. We used the time-stratified case-crossover study design to assess the association between the risk of ischemic stroke onset and PM2.5 levels in the hours and days preceding each event. We examined whether the association with PM2.5 differed by ischemic stroke etiology and patient characteristics. Results The estimated odds ratio of ischemic stroke onset was 1.34 (95% confidence interval (CI): 1.13, 1.58; p<0.001) following a 24-hour period classified as “moderate” (PM2.5 15–40 μg/m3) by the US Environmental Protection Agency’s (EPA) Air Quality Index compared to a 24-hour period classified as “good” (≤15 μg/m3). Considering PM2.5 as a continuous variable, the estimated odds ratio of ischemic stroke onset was 1.11 (95% CI: 1.03, 1.20; p=0.006) per interquartile range increase in PM2.5 (6.4 μg/m3). The increase in risk was greatest within 12–14 hours of exposure to PM2.5 and was most strongly associated with markers of traffic-related pollution. Conclusion These results suggest that exposure to PM2.5 levels considered generally safe by the US EPA increase the risk of ischemic stroke onset within hours of exposure.

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