Ambient ionization source based on a dielectric barrier discharge for direct testing of pharmaceuticals using ion mobility spectrometry

Chantipmanee, Nattapong; Furter, Jasmine S.; Hauser, Peter C.

doi:10.1016/j.aca.2022.339432

Cited by 11 publications

(8 citation statements)

References 24 publications

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“…111 The technique was similarly used to measure sildenafil, more commonly known as Viagra, in herbal medicines promising to treat erectile dysfunction, demonstrating the variation in the presence and abundance of the active ingredient in 12 different medicines purchased online. 112 Other AIMS techniques developed for direct pharmaceutical analysis include the coupling of a DBD ion source with ion mobility MS for the rapid analysis of several painkillers, allergy treatments and antibacterials, 113 and the use of DESI-MS high-throughput screening for drug discovery. 114 The analysis of pharmaceuticals in biological materials has gained more attention.…”

Section: Pharmaceuticalsmentioning

confidence: 99%

Applications of ambient ionization mass spectrometry in 2022: An annual review

Rankin‐Turner

Sears

Heaney

2023

Analytical Science Advances

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The development of ambient ionization mass spectrometry (AIMS) has transformed analytical science, providing the means of performing rapid analysis of samples in their native state, both in and out of the laboratory. The capacity to eliminate sample preparation and pre‐MS separation techniques, leading to true real‐time analysis, has led to AIMS naturally gaining a broad interest across the scientific community. Since the introduction of the first AIMS techniques in the mid‐2000s, the field has exploded with dozens of novel ion sources, an array of intriguing applications, and an evident growing interest across diverse areas of study. As the field continues to surge forward each year, ambient ionization techniques are increasingly becoming commonplace in laboratories around the world. This annual review provides an overview of AIMS techniques and applications throughout 2022, with a specific focus on some of the major fields of research, including forensic science, disease diagnostics, pharmaceuticals and food sciences. New techniques and methods are introduced, demonstrating the unwavering drive of the analytical community to further advance this exciting field and push the boundaries of what analytical chemistry can achieve.

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Section: Pharmaceuticalsmentioning

confidence: 99%

Applications of ambient ionization mass spectrometry in 2022: An annual review

Rankin‐Turner

Sears

Heaney

2023

Analytical Science Advances

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“…Ion-mobility spectrome-try can be used in conjunction with mass spectrometry to improve the specificity of the system. [96][97][98] Consequently, the combination with nanofluidic devices will allow for further improvement in specificity. Moreover, tandem mass spectrometry is another method used to enhance specificity.…”

Section: High Level Of Specificity and Selectivitymentioning

confidence: 99%

“…In particular, target analytes are present in complex biological samples. Ion‐mobility spectrometry can be used in conjunction with mass spectrometry to improve the specificity of the system 96‐98 . Consequently, the combination with nanofluidic devices will allow for further improvement in specificity.…”

Section: Perspectivesmentioning

confidence: 99%

Toward nanofluidics‐based mass spectrometry for exploring the unknown complex and heterogeneous subcellular worlds

Chantipmanee¹,

2022

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Exploring unknown matter in an ultrasmall volume object, such as unknown subcellular matter in a single cell, requires an analytical technique that identifies unknown matter in terms of molecular structures and properties. Mass spectrometry is considered one of the best techniques for such analyses because it can identify unknown matter according to its mass‐to‐charge ratio. However, the use of mass spectrometry to identify unknown substances in such a small world has been greatly impeded due to the lack of tools to sample complex and heterogeneous analytes with ultrasmall volumes of the picoliter order, which is the volume order of a mammalian cell. We believe that nanofluidics would be an ideal tool to resolve this critical issue owing to its ability to sample such fluid samples with ultrasmall volumes ranging from the picoliter to zeptoliter order. Thus, the integration of such nanofluidic features into mass spectrometers would open up future avenues for the potential of mass spectrometry to explore unknown subcellular matter at a nano scale. In this perspective, we first discuss the applicability of microfluidics/nanofluidics to mass spectrometry, then address critical issues toward nanofluidics‐based mass spectrometry, and finally depict a personal outlook on the future of this field to resolve challenges on global and universal scales.

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“…Commercially available IMS instruments usually employ a radioactive beta-emitter for analyte ionization of gaseous analytes [ 4 ]. However, alternative ionization methods are possible in the form of corona discharges [ 5 , 6 ], UV-ionization [ 7 , 8 ], or low-temperature plasmas [ 9 – 11 ]. Electrospray ionization, as a further option, has the advantage of being suitable for liquid samples containing non-volatile species [ 2 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

Determination of tobramycin in eye drops with an open-source hardware ion mobility spectrometer

Chantipmanee,

Hauser

2022

Anal Bioanal Chem

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The analysis of tobramycin was demonstrated successfully as an example for electrospray ionization on an open-source hardware ion mobility spectrometer. This instrument was assembled inexpensively in-house, and required only very few purpose-made components. The quantitative determination of tobramycin required 20 s for a reading. The calibration curve for the range from 50 to 200 μM was found to be linear with a correlation coefficient of r = 0.9994. A good reproducibility was obtained (3% relative standard deviation) and the limit of detection was determined as 8 μM. As the concentration of the active ingredient in the eye drops (ophthalmic solutions) is too high for the sensitivity of the instrument, the samples had to be diluted appropriately. Graphical abstract

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Ambient ionization source based on a dielectric barrier discharge for direct testing of pharmaceuticals using ion mobility spectrometry

Cited by 11 publications

References 24 publications

Applications of ambient ionization mass spectrometry in 2022: An annual review

Applications of ambient ionization mass spectrometry in 2022: An annual review

Toward nanofluidics‐based mass spectrometry for exploring the unknown complex and heterogeneous subcellular worlds

Determination of tobramycin in eye drops with an open-source hardware ion mobility spectrometer

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