volume 30, issue 2, P277-297 2012
DOI: 10.3233/jad-2012-111259
View full text
|
|
Share
Lucia Pastorino, Suk Ling Ma, Martin Balastik, Pengyu Huang, Darshan Pandya, Linda Nicholson, Kun Ping Lu

Abstract: Increased amyloidogenic processing of the amyloid-β protein precursor (AβPP) is a characteristic of Alzheimer's disease (AD). We previously observed that the prolyl isomerase Pin1, which is down-regulated in AD, regulates AβPP conformation accelerating cis/trans isomerization of the phospho-Thr668-Pro669 peptide bond, and that Pin1 knockout in mice increases the amyloidogenic processing of AβPP, although the underlying mechanism is still unknown. Since the intracellular localization of AβPP determines whether …

expand abstract