Alzheimer's disease neuropathologic change, Lewy body disease, and vascular brain injury in clinic- and community-based samples

Abstract

We examined the relationships between Alzheimer’s disease neuropathologic change (ADNC), Lewy body disease (LBD), and vascular brain injury (VBI) in two large autopsy samples. Because findings may differ between study populations, data came from U.S. Alzheimer’s Disease Centers contributing to the National Alzheimer’s Coordinating Center (NACC, n=2,742) and from the population-based Adult Changes in Thought study (ACT, n=499). Regardless of study population, over 50% of participants with ADNC had co-occurring LBD or VBI; the majority of whom had a clinical AD dementia diagnosis prior to death. Overlap of pathologies was similar between studies, especially after standardizing to the distribution of age and dementia status in the ACT population. LBD, but not VBI, was positively associated with ADNC in both studies. Interestingly, cortical LBD was more common in those with intermediate ADNC compared to low or high ADNC, especially in NACC (p<0.001). High prevalence of co-occurring neuropathologies among older adults with dementia has implications for accurate diagnosis of dementia etiologies and development of disease-modifying strategies.

Clinical characteristics of Lewy body dementia in Chinese memory clinics

“…A primary finding of the current study was the slight predominance of males in the LBD population, with the proportion of 52.5% ( n = 239), which is consistent with a previous study [ 33 ]. The gender distribution in those with DLB and PDD both showed the predominance of males (50.9% in those with DLB, 57.9% in those with PDD), with no differences in females.…”

Clinical characteristics of Lewy body dementia in Chinese memory clinics

“…A primary finding of the current study was the slight predominance of males in the LBD population, with the proportion of 52.5% ( n = 239), which is consistent with a previous study [ 33 ]. The gender distribution in those with DLB and PDD both showed the predominance of males (50.9% in those with DLB, 57.9% in those with PDD), with no differences in females.…”

Aging without Dementia is Achievable: Current Evidence from Epidemiological Research

“…Postmortem studies revealed that the brains of most centenarians exhibited extensive co-occurrence of multiple pathologies such as arteriolosclerosis, Alzheimer pathologies, hippocampal sclerosis, Lewy body pathology, and cerebral amyloid angiopathy, while Alzheimer pathology was not universal (∼60% with “moderate” neuritic amyloid plaque densities) [ 22, 23 ]. These findings are similar to those from octogenarians and nonagenarians [ 24 ]. Supercentenarians (age ≥110 years) are extremely rare in the world population (∼50 living supercentenarians in 2016, http://www.grg.org).…”

RNA Isoform Diversity in Human Neurodegenerative Diseases

“…While DLB and PD both exhibit Lewy body aggregation, DLB actually shared more DEGs with AD than with PD across all major cell types. The contribution of disease comorbidities may also be present, as previously reported based upon neuropathology but could also reflect shared mechanisms that deserve further study ( Brenowitz et al, 2017a , b , c ). GO analyses further indicated that many biological processes affected by changes in gene expression were unique to disease and cell type, with only excitatory neurons in all three diseases sharing multiple GO terms.…”

Clinical characteristics of Lewy body dementia in Chinese memory clinics

“…A primary finding of the current study was the slight predominance of males in the LBD population, with the proportion of 52.5% ( n = 239), which is consistent with a previous study [ 33 ]. The gender distribution in those with DLB and PDD both showed the predominance of males (50.9% in those with DLB, 57.9% in those with PDD), with no differences in females.…”

Aging without Dementia is Achievable: Current Evidence from Epidemiological Research

“…Postmortem studies revealed that the brains of most centenarians exhibited extensive co-occurrence of multiple pathologies such as arteriolosclerosis, Alzheimer pathologies, hippocampal sclerosis, Lewy body pathology, and cerebral amyloid angiopathy, while Alzheimer pathology was not universal (∼60% with “moderate” neuritic amyloid plaque densities) [ 22, 23 ]. These findings are similar to those from octogenarians and nonagenarians [ 24 ]. Supercentenarians (age ≥110 years) are extremely rare in the world population (∼50 living supercentenarians in 2016, http://www.grg.org).…”

RNA Isoform Diversity in Human Neurodegenerative Diseases

“…While DLB and PD both exhibit Lewy body aggregation, DLB actually shared more DEGs with AD than with PD across all major cell types. The contribution of disease comorbidities may also be present, as previously reported based upon neuropathology but could also reflect shared mechanisms that deserve further study ( Brenowitz et al, 2017a , b , c ). GO analyses further indicated that many biological processes affected by changes in gene expression were unique to disease and cell type, with only excitatory neurons in all three diseases sharing multiple GO terms.…”

Clinical characteristics of Lewy body dementia in Chinese memory clinics

“…A primary finding of the current study was the slight predominance of males in the LBD population, with the proportion of 52.5% ( n = 239), which is consistent with a previous study [ 33 ]. The gender distribution in those with DLB and PDD both showed the predominance of males (50.9% in those with DLB, 57.9% in those with PDD), with no differences in females.…”

Aging without Dementia is Achievable: Current Evidence from Epidemiological Research

“…Postmortem studies revealed that the brains of most centenarians exhibited extensive co-occurrence of multiple pathologies such as arteriolosclerosis, Alzheimer pathologies, hippocampal sclerosis, Lewy body pathology, and cerebral amyloid angiopathy, while Alzheimer pathology was not universal (∼60% with “moderate” neuritic amyloid plaque densities) [ 22, 23 ]. These findings are similar to those from octogenarians and nonagenarians [ 24 ]. Supercentenarians (age ≥110 years) are extremely rare in the world population (∼50 living supercentenarians in 2016, http://www.grg.org).…”

RNA Isoform Diversity in Human Neurodegenerative Diseases

“…While DLB and PD both exhibit Lewy body aggregation, DLB actually shared more DEGs with AD than with PD across all major cell types. The contribution of disease comorbidities may also be present, as previously reported based upon neuropathology but could also reflect shared mechanisms that deserve further study ( Brenowitz et al, 2017a , b , c ). GO analyses further indicated that many biological processes affected by changes in gene expression were unique to disease and cell type, with only excitatory neurons in all three diseases sharing multiple GO terms.…”