Alzheimer's Disease

Vulnerability of mitochondrial OXPHOS complexes in the arcuate nucleus of the hypothalamus of Alzheimer's disease

“… 12 , 58 Accordingly, ARH deregulation has been linked to dysmetabolic states such as obesity and diabetes mellitus, 59 , 60 which have been repeatedly associated with AD development. 61 – 64 Although the detailed mechanisms of ARH vulnerability in AD remain unclear, previous pathological studies have determined ARH damage and suggested its potential association with cognitive deficits in both patients and AD animal models, 22 , 23 , 26 , 65 , 66 further highlighting the involvement of ARH dysfunction in AD pathogenesis. In this study, we observed impaired mitochondrial complex IV in ARH neuronal mitochondria from patients with AD.…”

Vulnerability of mitochondrial OXPHOS complexes in the arcuate nucleus of the hypothalamus of Alzheimer's disease

“… 12 , 58 Accordingly, ARH deregulation has been linked to dysmetabolic states such as obesity and diabetes mellitus, 59 , 60 which have been repeatedly associated with AD development. 61 – 64 Although the detailed mechanisms of ARH vulnerability in AD remain unclear, previous pathological studies have determined ARH damage and suggested its potential association with cognitive deficits in both patients and AD animal models, 22 , 23 , 26 , 65 , 66 further highlighting the involvement of ARH dysfunction in AD pathogenesis. In this study, we observed impaired mitochondrial complex IV in ARH neuronal mitochondria from patients with AD.…”

Associations of Upper Arm and Thigh Circumferences with Dementia and Depression in Korean Elders

“…Early neurodegenerative changes may influence feelings of hunger and fullness and the homeostatic control of energy consumption. There are two potential explanations for this: 1) the serotonin level decreases in the lateral hypothalamus, as demonstrated in cases of Alzheimer's dementia;31 or 2) weight loss or changes in body composition are the result of a stress response related to the deterioration of the brain function 32. Excessive weight loss increases brain atrophy.…”

Noradrenergic Hypothesis Linking Neurodegeneration-Based Cognitive Decline and Astroglia

“…There have also been conflicting reports regarding the NA levels in the brain of AD patients. In fact, while some studies have reported marked decline in regional NA brain tissue content, whose magnitude correlated with the severity of cognitive impairments (Martignoni et al, 1992 ; Nazarali and Reynolds, 1992 ; Matthews et al, 2002 ; Chen et al, 2014 ), others reported no changes (Sparks et al, 1988 ; Herregodts et al, 1989 ; Tohgi et al, 1992 ) or even increased NA levels (Tohgi et al, 1992 ; Elrod et al, 1997 ).…”

Vulnerability of mitochondrial OXPHOS complexes in the arcuate nucleus of the hypothalamus of Alzheimer's disease

“… 12 , 58 Accordingly, ARH deregulation has been linked to dysmetabolic states such as obesity and diabetes mellitus, 59 , 60 which have been repeatedly associated with AD development. 61 – 64 Although the detailed mechanisms of ARH vulnerability in AD remain unclear, previous pathological studies have determined ARH damage and suggested its potential association with cognitive deficits in both patients and AD animal models, 22 , 23 , 26 , 65 , 66 further highlighting the involvement of ARH dysfunction in AD pathogenesis. In this study, we observed impaired mitochondrial complex IV in ARH neuronal mitochondria from patients with AD.…”

Associations of Upper Arm and Thigh Circumferences with Dementia and Depression in Korean Elders

“…Early neurodegenerative changes may influence feelings of hunger and fullness and the homeostatic control of energy consumption. There are two potential explanations for this: 1) the serotonin level decreases in the lateral hypothalamus, as demonstrated in cases of Alzheimer's dementia;31 or 2) weight loss or changes in body composition are the result of a stress response related to the deterioration of the brain function 32. Excessive weight loss increases brain atrophy.…”

Noradrenergic Hypothesis Linking Neurodegeneration-Based Cognitive Decline and Astroglia

“…There have also been conflicting reports regarding the NA levels in the brain of AD patients. In fact, while some studies have reported marked decline in regional NA brain tissue content, whose magnitude correlated with the severity of cognitive impairments (Martignoni et al, 1992 ; Nazarali and Reynolds, 1992 ; Matthews et al, 2002 ; Chen et al, 2014 ), others reported no changes (Sparks et al, 1988 ; Herregodts et al, 1989 ; Tohgi et al, 1992 ) or even increased NA levels (Tohgi et al, 1992 ; Elrod et al, 1997 ).…”

Vulnerability of mitochondrial OXPHOS complexes in the arcuate nucleus of the hypothalamus of Alzheimer's disease

“… 12 , 58 Accordingly, ARH deregulation has been linked to dysmetabolic states such as obesity and diabetes mellitus, 59 , 60 which have been repeatedly associated with AD development. 61 – 64 Although the detailed mechanisms of ARH vulnerability in AD remain unclear, previous pathological studies have determined ARH damage and suggested its potential association with cognitive deficits in both patients and AD animal models, 22 , 23 , 26 , 65 , 66 further highlighting the involvement of ARH dysfunction in AD pathogenesis. In this study, we observed impaired mitochondrial complex IV in ARH neuronal mitochondria from patients with AD.…”

Associations of Upper Arm and Thigh Circumferences with Dementia and Depression in Korean Elders

“…Early neurodegenerative changes may influence feelings of hunger and fullness and the homeostatic control of energy consumption. There are two potential explanations for this: 1) the serotonin level decreases in the lateral hypothalamus, as demonstrated in cases of Alzheimer's dementia;31 or 2) weight loss or changes in body composition are the result of a stress response related to the deterioration of the brain function 32. Excessive weight loss increases brain atrophy.…”

Noradrenergic Hypothesis Linking Neurodegeneration-Based Cognitive Decline and Astroglia

“…There have also been conflicting reports regarding the NA levels in the brain of AD patients. In fact, while some studies have reported marked decline in regional NA brain tissue content, whose magnitude correlated with the severity of cognitive impairments (Martignoni et al, 1992 ; Nazarali and Reynolds, 1992 ; Matthews et al, 2002 ; Chen et al, 2014 ), others reported no changes (Sparks et al, 1988 ; Herregodts et al, 1989 ; Tohgi et al, 1992 ) or even increased NA levels (Tohgi et al, 1992 ; Elrod et al, 1997 ).…”