Alveolar soft-part sarcoma: can MRI help discriminating from other soft-tissue tumors? A study of the French sarcoma group

Crombé, Amandine; Brisse, H.; Ledoux, Pauline; Haddag‐Miliani, Leila; Bouhamama, Amine; Taïeb, S.; Loarer, François Le; Kind, Michèle

doi:10.1007/s00330-018-5903-3

Cited by 18 publications

(22 citation statements)

References 42 publications

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“…It is postulated that due to the characteristic translocation involving X chromosome, ASPS is twice more probable to occur in females. 4,9,10 The most common site of occurrence in our study was found to be extremities (10 of 16 cases) which is in concordance with other authors 4,9-11 (►Figs. 2 and 3).…”

Section: Discussionsupporting

confidence: 93%

“…4 Small case series or reviews with maximum of 25 cases of ASPS are present in literature due to the rarity of the disease. 9 Most of the cases of this rare tumor occur in children and young adults. The age group of the cases in our study ranged from 3 years to 72 years with the mean age of 29.25 years of age.…”

Section: Discussionmentioning

confidence: 99%

“…Feeder vessels within and in the periphery of the tumor are typical. 4 9 10 11 12 Metastases most commonly to the lung are present at the time of presentation 4 9 10 . This study was conducted to review and determine the imaging features of ASPS patients visiting dedicated sarcoma clinic of our tertiary care center.…”

Section: Introductionmentioning

confidence: 99%

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Imaging and Pathological Features of Alveolar Soft Part Sarcoma: Analysis of 16 Patients

Gulati

Mittal

Barwad

et al. 2021

Indian J Radiol Imaging

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Context Alveolar soft part sarcoma (ASPS) is a rare soft tissue tumor most commonly occurring in deep intramuscular plane of lower extremities of adolescents and young adults. It is a highly vascular, slow growing tumor with malignant potential having lung as the most common site of metastases at the time of presentation. Aims The aim is to review the imaging findings of ASPS and determine characteristic imaging features of this rare tumor. Materials and Methods Sixteen patients having histopathological diagnosis and preoperative imaging of ASPS attending the dedicated sarcoma clinic at our institute were included in the study. The demographic, clinical, and imaging data were retrieved from the case records and then evaluated for characteristic imaging features which may raise suspicion of ASPS. Results The patients ranged from 3 to 72 years of age and with a slight male preponderance. Of the eight CECTs evaluated, 62.5% tumors showed well-defined lobulated margins, 87.5% cases showed intense enhancement with presence of feeder vessels. On CEMRI of 10 patients, 70% had well circumscribed lobulated margins with intense enhancement and tortuous flow voids in most of them. All cases showed T2 hyperintense signal. Fourteen of 16 (87.5%) patients had metastatic disease with lung as the most common site (92.8%). Conclusion ASPS is a rare soft tissue sarcoma seen in children and young adults. Imaging may mimic a vascular malformation due to the presence of tortuous feeders. Misdiagnosis at an early stage may lead to later metastatic presentation of the disease, thus emphasizing the need to suspect it on imaging.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

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Imaging and Pathological Features of Alveolar Soft Part Sarcoma: Analysis of 16 Patients

Gulati

Mittal

Barwad

et al. 2021

Indian J Radiol Imaging

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“…Sometimes a murmur can be heard clinically and may be confused with arteriovenous malformations (7,8). Furthermore, according to a recently published study, MRI findings of ASPS may be misdiagnosed as benign tumors, pseudo-tumors, particularly intramuscular benign vascular tumors or vascular malformations (13).…”

Section: Discussionmentioning

confidence: 99%

Surgical Treatment of Alveolar Soft Part Sarcoma of the Extremity: Results of at Least 5 Years of Follow-up

Öztürk¹,

Atalay²,

Bulut³

et al. 2020

Bezmialem Science

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Objective: Alveolar soft part sarcoma (ASPS) is a rare soft tissue tumor that usually affects young patients. Because of the rarity of the disease, most reports relating to ASPS are in the form of case reports or small series. Methods: We performed a retrospective study to evaluate the clinic features, treatment and outcome in a consecutive series of patients with localized or metastatic ASPS between 2004 and 2014. Demographics, tumor sizes, sites of tumor and extent of disease, treatments provided, progression, and overall survival were evaluated. Results: Total of 8 patients were identified. The clinical assumptive diagnosis of the doctor making first medical examination was benign soft tissue tumor like hemangioma in 3 cases (37.5%), delaying treatment. The most common loca¬tion of primary tumor was the thigh. The median diameter of the mass was 136.8±76.0 mm (range=4-572 mm). Median overall follow-up was 64 months. Conclusion: It was found that age greater than 28 years at the time of diagnosis, and the non-thigh placement of the tumor on the limb were found to increase the risk of lung metastasis. It was found that 37.5% of the patients underwent inadequate operation with the pre-diagnosis of vascular-related benign tumors. So, a comprehensive preoperative evaluation for the differential diagnosis of ASPS is needed when interfering with hemangioma-like vascular associated tumors.

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“…Malignant tumours of uncertain differentiation tend to have aggressive MRI features. Of these, alveolar soft-part sarcomas (ASPS) tend to exhibit eight MRI features more often: deep location relative to the superficial fascia, elevated signal on T1-weighted imaging, intralesional necrosis, lack of fibrotic component, infiltrative growth pattern, absence of tail sign, presence of intra- and perilesional flow-voids, and more than five flow voids suggesting neovascularity [ 36 ]. Although these features are not diagnostic of ASPS, their presence is compatible with the diagnosis and suggests an aggressive histology that should be referred to a sarcoma centre and worked up appropriately.…”

Section: Tumours Of Uncertain Differentiationmentioning

confidence: 99%

Revisiting the WHO classification system of soft tissue tumours: emphasis on advanced magnetic resonance imaging sequences. Part 1

Ahlawat¹,

Fayad²

2020

Pol J Radiol

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The World Health Organisation (WHO) classification categorises musculoskeletal soft tissue tumours (STT) based on their similarity to normal adult tissue. The most recent WHO classification provides an updated scheme that in tegrates biological behaviour as a distinguishing feature in each subcategory; STTs are further subdivided as benign, intermediate (locally aggressive or rarely metastasising), and malignant. Although malignant STTs are infrequent in routine orthopaedic radiology practice, musculoskeletal radiologists must be familiar with the imaging appearance of malignant STTs and distinguish them from their benign counterparts for appropriate management. Magnetic res onance imaging (MRI) is the ideal modality for the detection, characterisation, and local staging of STT. This review will discuss the most recent updates to the WHO classification of STT that are relevant to radiologists in a routine clinical practice with MRI correlation. The utility of advanced MRI sequences such as diffusion weighted imaging, dynamic contrast enhanced sequences, and magnetic resonance spectroscopy to provide insight into the biological behaviour of various STTs is highlighted.

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Alveolar soft-part sarcoma: can MRI help discriminating from other soft-tissue tumors? A study of the French sarcoma group

Cited by 18 publications

References 42 publications

Imaging and Pathological Features of Alveolar Soft Part Sarcoma: Analysis of 16 Patients

Imaging and Pathological Features of Alveolar Soft Part Sarcoma: Analysis of 16 Patients

Surgical Treatment of Alveolar Soft Part Sarcoma of the Extremity: Results of at Least 5 Years of Follow-up

Revisiting the WHO classification system of soft tissue tumours: emphasis on advanced magnetic resonance imaging sequences. Part 1

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