Aluminum: A potentially toxic metal with dose-dependent effects on cardiac bioaccumulation, mineral distribution, DNA oxidation and microstructural remodeling

Novaes, Rômulo Dias; Mouro, Viviane Gorete Silveira; Gonçalves, Reggiani Vilela; Mendonça, Andréa A.S.; Santos, Eliziária Cardoso dos; Fialho, Maria C.Q.; Machado‐Neves, Mariana

doi:10.1016/j.envpol.2018.07.034

Cited by 32 publications

(17 citation statements)

References 52 publications

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“…Al-induced damages are possibly mediated by the induction of the caspase-3 gene [ 69 ]. It is known that the functioning of nervous networks requires efficient neurotransmission, and the presence of Al in the CNS causes changes in electrical excitability, impairs synaptic transmission, and voltage-controlled ion channels [ 70 ]. Specifically, Al 3+ inhibits voltage-gated Ca 2+ channels by reducing the maximal velocity of Ca 2+ influx and inhibiting neurotransmitter receptors [ 71 ].…”

Section: Discussionmentioning

confidence: 99%

Multi-Elemental Analysis of Human Optic Chiasm—A New Perspective to Reveal the Pathomechanism of Nerve Fibers’ Degeneration

Baj

Forma

Kowalska

et al. 2022

IJERPH

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The effect of metals on the functioning of the human eye is multifactorial and includes enzyme activity modulation, trace metal metabolic pathways changes, and cytotoxic activity. Functional dysfunctions appear mostly as a result of the accumulation of toxic xenobiotic metals or disturbances of micronutrients’ homeostasis. So far, the affinity of selected metals to eye tissues, i.e., the cornea, choroid, lens, and anterior chamber fluid, has been most studied. However, it is known that many eye symptoms are related to damage to the optic nerve. In order to fill this gap, the aim of the study is to perform a multi-element analysis of tissue collected postmortem from optic chiasm and optic nerves. A total of 178 samples from 107 subjects were tested. The concentrations of 51 elements were quantified by inductively coupled plasma mass spectrometry (ICP-MS) after the wet-mineralization step. In terms of elemental composition, the optic chiasm is dominated by two trace elements, i.e., iron (Fe) and zinc (Zn), besides macro-elements Ca, K, Na, P, and Mg. The subjects formed a homogeneous cluster (over 70% subjects) with the highest accumulation of aluminum (Al). The remaining two departing clusters were characterized by an increased content of most of the elements, including toxic elements such as bismuth (Bi), uranium (U), lead (Pb), chromium (Cr), and cadmium (Cd). Changes in elemental composition with age were analyzed statistically for the selected groups, i.e., females, males, and subjects with alcohol use disorder (AUD) and without AUD. A tendency of women to lose Se, Cu, Zn, Fe with age was observed, and a disturbed Ca/Mg, Na/K ratio in subjects with AUD. Although the observed trends were not statistically significant, they shed new light on the risks and possible pathologies associated with metal neurotoxicity in the visual tract.

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Section: Discussionmentioning

confidence: 99%

Multi-Elemental Analysis of Human Optic Chiasm—A New Perspective to Reveal the Pathomechanism of Nerve Fibers’ Degeneration

Baj

Forma

Kowalska

et al. 2022

IJERPH

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“…Ghorbel et al [ 47 ] presented that aluminum treatment created significant cardiotoxicity with oxidative damage in experimental animals. In another animal study, Novaes et al [ 48 ] proved that heart was vulnerable to aluminum toxicity. Long-term aluminum treatment produced genomic DNA oxidation, structural irregularities of myocardium, causing widespread parenchymal loss, stromal enlargement, inflammatory cell infiltrations, collagen deposition, breakdown of collagen network, decreased myocardial vascularization, mitochondrial swelling, sarcomere disorder, myofilament separation, and fragmentation of cardiomyocytes.…”

Section: Discussionmentioning

confidence: 99%

Blood Aluminum Levels in Patients with Hemodialysis and Peritoneal Dialysis

Chuang

Tsai

Wang

et al. 2022

IJERPH

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Background. This retrospective observational study attempted to examine the prevalence of abnormal blood aluminum levels in dialysis patients, and to explore the association of pathogenic factors, such as demographic, clinical, laboratory as well as the use of phosphate binding drugs, drugs for secondary hyperparathyroidism and erythropoiesis-stimulating drugs with the blood aluminum levels. Methods. The study included 1175 patients (874 hemodialysis and 301 peritoneal dialysis), recruited from Chang Gung Memorial Hospital in November 2020. Patients were stratified into two groups by their blood aluminum levels, as normal (<2 µg/dL, n = 1150) or abnormal (≥2 µg/dL, n = 25). Results. The patients aged 60.4 ± 13.2 years and were dialyzed for 8.6 ± 8.1 years. The average blood aluminum level was 1.0 ± 0.4 µg/dL. Patients with abnormal blood aluminum levels received more sevelamer than patients with normal blood aluminum level (p = 0.014). Patients with abnormal blood aluminum levels had higher platelet count (p = 0.001), triglyceride (p < 0.001) and total iron binding capacity (p = 0.003) than patients with normal blood aluminum levels. Moreover, the cardiothoracic ratio was higher in patients with abnormal blood aluminum levels than patients with normal blood aluminum levels (p = 0.003). Conclusions. The prevalence of abnormal blood aluminum levels was low at 2.2%. Nevertheless, the linking of cardiothoracic ratio of more than 0.5 as well as elevated blood platelet count and triglyceride level with blood aluminum levels are interesting, and warranted more researches in this area.

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“…The obtained result is different from observed by Ghorbel, Elwej [31] who found that rats received AlCl 3 (400 ppm) for 21 days via drinking water induced cardiotoxicity. Novaes, Mouro [32] found that three highest doses of Al for 120 days induced heart toxicity and Gouda, El-Nabarawy [33] found that aluminium phosphide caused significant cardiac histopathological changes. These results are quite different than current study due to variation in dose and exposure duration.…”

Section: Discussionmentioning

confidence: 99%

Histological study on the acute injection of aluminum sulfate on different organs of rats

El-Hak

Eladawy

Rashwan

et al. 2020

Frontiers in Scientific Research and Technology

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Aluminum: A potentially toxic metal with dose-dependent effects on cardiac bioaccumulation, mineral distribution, DNA oxidation and microstructural remodeling

Cited by 32 publications

References 52 publications

Multi-Elemental Analysis of Human Optic Chiasm—A New Perspective to Reveal the Pathomechanism of Nerve Fibers’ Degeneration

Multi-Elemental Analysis of Human Optic Chiasm—A New Perspective to Reveal the Pathomechanism of Nerve Fibers’ Degeneration

Blood Aluminum Levels in Patients with Hemodialysis and Peritoneal Dialysis

Histological study on the acute injection of aluminum sulfate on different organs of rats

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