Alternatives to Antibiotics to Prevent Necrotic Enteritis in Broiler Chickens: A Microbiologist's Perspective

Caly, Delphine L.; d'Inca, Romain; Auclair, Eric; Drider, Djamel

doi:10.3389/fmicb.2015.01336

Cited by 199 publications

(163 citation statements)

References 133 publications

(164 reference statements)

Supporting

Mentioning

152

Contrasting

Unclassified

Order By: Relevance

“…In the literature, many alternatives to antimicrobial usage in food-producing animals have been reported and discussed [87][88][89][90]. The most promising way to mitigate the development of colistin resistance is to reduce the use of antimicrobials at the farm level ( Table 2).…”

Section: Preventive Measuresmentioning

confidence: 99%

Post weaning diarrhea in pigs: risk factors and non-colistin-based control strategies

et al. 2017

View full text Add to dashboard Cite

Post-weaning diarrhea (PWD) is one of the most serious threats for the swine industry worldwide. It is commonly associated with the proliferation of enterotoxigenic Escherichia coli in the pig intestine. Colistin, a cationic antibiotic, is widely used in swine for the oral treatment of intestinal infections caused by E. coli, and particularly of PWD. However, despite the effectiveness of this antibiotic in the treatment of PWD, several studies have reported high rates of colistin resistant E. coli in swine. Furthermore, this antibiotic is considered of very high importance in humans, being used for the treatment of infections due to multidrug-resistant (MDR) Gram-negative bacteria (GNB). Moreover, the recent discovery of the mcr-1 gene encoding for colistin resistance in Enterobacteriaceae on a conjugative stable plasmid has raised great concern about the possible loss of colistin effectiveness for the treatment of MDR-GNB in humans. Consequently, it has been proposed that the use of colistin in animal production should be considered as a last resort treatment only. Thus, to overcome the economic losses, which would result from the restriction of use of colistin, especially for prophylactic purposes in PWD control, we believe that an understanding of the factors contributing to the development of this disease and the putting in place of practical alternative strategies for the control of PWD in swine is crucial. Such alternatives should improve animal gut health and reduce economic losses in pigs without promoting bacterial resistance. The present review begins with an overview of risk factors of PWD and an update of colistin use in PWD control worldwide in terms of quantities and microbiological outcomes. Subsequently, alternative strategies to the use of colistin for the control of this disease are described and discussed. Finally, a practical approach for the control of PWD in its various phases is proposed.

show abstract

Section: Preventive Measuresmentioning

confidence: 99%

Post weaning diarrhea in pigs: risk factors and non-colistin-based control strategies

et al. 2017

View full text Add to dashboard Cite

show abstract

“…It typically occurs in broilers aged from 2 to 6 weeks and leads to sudden death (Abudabos, Alyemni, & Al Marshad, ; Kaldhusdal & Løvland, ; Lee, Lillehoj, Jeong, Jeoung, & An, ; Timbermont, Haesebrouck, Ducatelle, & Van Immerseel, ; Van Immerseel et al., ). Antibiotics have been commonly used worldwide as growth promoters and for prophylactic treatment of C. perfringens ‐induced NE in poultry (Caly, D'Inca, Auclair, & Drider, ; Van Immerseel et al., ). However, the European Union introduced a ban on the use of antibiotics in animal production, resulting in increased NE outbreaks in broilers in European countries (Van der Sluis, ; Van Immerseel et al., ).…”

Section: Introductionmentioning

confidence: 99%

Optimization of surfactin production from Bacillus subtilis in fermentation and its effects on Clostridium perfringens‐induced necrotic enteritis and growth performance in broilers

Cheng

Zhang

Han

et al. 2018

Animal Physiology Nutrition

View full text Add to dashboard Cite

Bacillus species are commonly used as probiotics in the poultry feed industry for preventing infectious diseases and improving productivity by altering gastrointestinal microbiota. The growth parameters of Bacillus subtilis for surfactin production in fermentation and the benefits of surfactin on broiler chickens remain unclear. In this study, we examined the growth parameters of B. subtilis in fermentation and evaluated the effects of surfactin from B. subtilis-fermented products on Clostridium perfringens-induced necrotic enteritis and growth performance in broilers. Results showed that the highest viable biomass of B. subtilis was observed at 10% molasses and 2% yeast supplementation during fermentation. The 4- and 6-day fermented B. subtilis products were heat-, acid- and bile-resistant. Furthermore, the 4-day fermented B. subtilis products with the highest surfactin concentration showed the maximal antimicrobial activity against pathogens, including Escherichia coli, Staphylococcus aureus, Salmonella typhimurium and C. perfringens. Dietary B. subtilis-fermented product supplementation in broilers significantly improved intestinal morphology and necrotic lesions under C. perfringens challenge. Bacillus subtilis treatments could enhance broiler productivity, as well as promote bone quality and intestinal morphology. These results together indicate that B. subtilis-fermented products containing surfactin have potential for the development as feed additives and use as possible substitutes for antibiotics to treat C. perfringens in the poultry industry.

show abstract

“…Therefore, in this work, AV confirmed its potential to suppress gut microbiota members such as Lactobacillus and C. perfringens (Kim, Seo, Kim, & Paik, ; Knarreborg, Simon, Engberg, Jensen, & Tannock, ; Mountzouris, ). Suppression of C. perfringens overgrowth in particular is beneficial for poultry as C. perfringens subclinical infections are associated with chronic damage of the intestinal mucosa and necrotic enteritis (Caly, D'Inca, Auclair, & Drider, ).…”

Section: Discussionmentioning

confidence: 99%

“…‡ Interaction means (treatments) from 10 broilers per treatment: CoN: basal diet with no other additions; CoN + A: addition of 2.5 mg avilamycin/kg diet; ViP: addition of 1 g viable probiotic/kg diet; ViP + A: addition of 1 g viable probiotic + 2.5 mg of avilamycin/kg diet; InP: addition of 1 g inactivated probiotic/kg diet; and InP + A: addition of 1 g inactivated probiotic + 2.5 mg of avilamycin/kg diet. § Pooled standard error of means.of C. perfringens overgrowth in particular is beneficial for poultry as C. perfringens subclinical infections are associated with chronic damage of the intestinal mucosa and necrotic enteritis(Caly, D'Inca, Auclair, & Drider, 2015).…”

mentioning

confidence: 99%

Dietary probiotic form modulates broiler gut microbiota indices and expression of gut barrier genes including essential components for gut homeostasis

Mountzouris

Palamidi

Paraskeuas

et al. 2019

Animal Physiology Nutrition

View full text Add to dashboard Cite

The probiotic form (PF) type and its dietary administration in combination or not with avilamycin (AV) were investigated for their effects on broiler gut microbiota and expression of genes relevant for gut barrier and gut homeostasis. Depending on PF type (i.e. no addition, viable, inactivated) and AV addition (no/yes), 450 one‐day‐old Cobb male broilers were allocated in 6 treatments (CON, CON + A, ViP, ViP + A, InP and InP + A) according to a 3 × 2 factorial arrangement with 5 replicates of 15 broilers each for 42 days. Significant interactions (PPF × AV ≤ 0.05) between PF and AV administration were shown for the ileal mucosa‐associated bacteria, the caecal digesta Lactobacillus spp., the molar ratio of the sum of valeric, hexanoic and heptanoic acids and the gene expressions of ileal and caecal IgA and ileal claudin 1. Avilamycin suppressed ileal digesta Lactobacillus spp. (PAV < 0.001) and caecal digesta Clostridium perfringens subgroup (PAV = 0.018) and modulated the intestinal fermentation intensity and pattern. The viable PF had the higher levels of ileal digesta Bacteroides spp. (PPF = 0.021) and caecal digesta Lactobacillus spp. (PPF = 0.038) compared with the other two PF. Probiotic form modulated the microbial metabolic activity in the ileum and caeca with the viable PF being the most noteworthy in terms of effects regarded as beneficial. Furthermore, the viable PF resulted in reduced expression of caecal Toll‐like receptors TLR2B (PPF = 0.026) and TLR4 (PPF = 0.011) and transcription factor NFΚΒ1 (PPF = 0.002), which could be considered as essential for limiting inflammation and preserving gut homeostasis. In conclusion, under non‐challenge conditions, probiotic function was shown to depend on PF type and to a lesser degree on co‐administration with AV. The importance of probiotic viability for the beneficial modulation of important gut components towards a reduced state of physiological inflammation has been highlighted.

show abstract

Alternatives to Antibiotics to Prevent Necrotic Enteritis in Broiler Chickens: A Microbiologist's Perspective

Cited by 199 publications

References 133 publications

Post weaning diarrhea in pigs: risk factors and non-colistin-based control strategies

Post weaning diarrhea in pigs: risk factors and non-colistin-based control strategies

Optimization of surfactin production from Bacillus subtilis in fermentation and its effects on Clostridium perfringens‐induced necrotic enteritis and growth performance in broilers

Dietary probiotic form modulates broiler gut microbiota indices and expression of gut barrier genes including essential components for gut homeostasis

Contact Info

Product

Resources

About