Alternating co-synthesis of glycol nucleic acid (GNA) monomers with dicarboxylic acids <i>via</i> drying

Yi, Ruiqin; Jia, Tony Z.; Meringer, Markus; Marshall, Luke K.; Chen, Chen; McGlynn, Shawn E.; Fahrenbach, Albert C.; Cleaves, Henderson James

doi:10.1039/d2cc06818d

Chem. Commun.

2023

DOI: 10.1039/d2cc06818d

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Alternating co-synthesis of glycol nucleic acid (GNA) monomers with dicarboxylic acids via drying

Ruiqin Yi

Tony Z. Jia

Markus Meringer

et al.

Abstract: We report the co-polymerization of glycol nucleic acid (GNA) monomers with unsubstituted and substituted dicarboxylic acid linkers under plausible early Earth aqueous dry-down conditions. Both linear and branched co-polymers are...

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C2-addition patterns emerging from acetylene and nickel sulfide in simulated prebiotic hydrothermal conditions

Diederich,

Ruf,

Geisberger

et al. 2023

Commun Chem

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Chemical complexity is vital not only for the origin of life but also for biological evolution. The chemical evolution of a complex prebiotic mixture containing acetylene, carbon monoxide (CO), and nickel sulfide (NiS) has been analyzed with mass spectrometry as an untargeted approach to reaction monitoring. Here we show through isotopic 13C-labelling, multiple reaction products, encompassing diverse CHO and CHOS compounds within the complex reaction mixture. Molecules within the same chemical spaces displayed varying degrees of 13C-labelling, enabling more robust functional group characterization based on targeted investigations and differences in saturation levels among the described classes. A characteristic C2-addition pattern was detected in all compound classes in conjunction with a high diversity of thio acids, reminiscent of extant microbial C2-metabolism. The analysis involved a time-resolved molecular network, which unveiled the behavior of sulfur in the system. At the onset of the reaction, early formed compounds contain more sulfur atoms compared to later emerging compounds. These results give an essential insight into the still elusive role of sulfur dynamics in the origin of life. Moreover, our results provide temporally resolved evidence of the progressively increasing molecular complexity arising from a limited number of compounds.

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C2-addition patterns emerging from acetylene and nickel sulfide in simulated prebiotic hydrothermal conditions

Diederich,

Ruf,

Geisberger

et al. 2023

Commun Chem

View full text Add to dashboard Cite

show abstract

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Alternating co-synthesis of glycol nucleic acid (GNA) monomers with dicarboxylic acids via drying

Abstract: We report the co-polymerization of glycol nucleic acid (GNA) monomers with unsubstituted and substituted dicarboxylic acid linkers under plausible early Earth aqueous dry-down conditions. Both linear and branched co-polymers are...

Cited by 1 publication

References 24 publications

C2-addition patterns emerging from acetylene and nickel sulfide in simulated prebiotic hydrothermal conditions

C2-addition patterns emerging from acetylene and nickel sulfide in simulated prebiotic hydrothermal conditions

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