volume 66, issue 7, P4382-4389 1992
DOI: 10.1128/jvi.66.7.4382-4389.1992
View full text

Abstract: The hepatitis B virus X gene encodes a transcription activator which stimulates the synthesis of RNAs from a variety of class II and III promoter elements. In this report, we present a mutational analysis which genetically demonstrates that the X gene actually encodes two, and possibly three, related polypeptides from a single mRNA using alternate translation initiation from any of three in-frame AUG codons. Genetic analysis shows that translation initiates at the 5' proximal AUG of X mRNA and produces a full-…

Expand abstract