Altered Topological Properties of Functional Network Connectivity in Schizophrenia during Resting State: A Small-World Brain Network Study

Yu, Qingbao; Sui, Jing; Rachakonda, Srinivas; He, Hao; Gruner, William; Pearlson, Godfrey D.; Kiehl, Kent A.; Calhoun, Vince D.

doi:10.1371/journal.pone.0025423

Cited by 129 publications

(113 citation statements)

References 91 publications

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“…2008; Yu et al. 2011) in patients with psychotic disorder compared to healthy controls. Of note, the sample size of this study ( N = 228) was considerably higher compared to other studies ( N < 62).…”

Section: Discussionmentioning

confidence: 98%

“…However, a previous graph theoretical study found an association between negative symptoms and different topological properties (i.e., characteristic path length and global efficiency) which was not observed in this study (Yu et al. 2011). These inconsistencies may be due to the analyzing techniques used by the two studies.…”

Section: Discussionmentioning

confidence: 99%

“…2008; Yu et al. 2011) but there are also reports of shorter path length and higher global efficiency (Alexander‐Bloch et al. 2010; Lynall et al.…”

Section: Introductionmentioning

confidence: 99%

“…2010; Yu et al. 2011). Two of these studies did not find an association between topological measures and clinical correlates, but Yu et al.…”

Section: Introductionmentioning

confidence: 99%

“…Two of these studies did not find an association between topological measures and clinical correlates, but Yu et al. (2011) reported that negative symptoms were associated with a longer characteristic path length and lower global efficiency, whereas no association with positive symptoms was found.…”

Section: Introductionmentioning

confidence: 99%

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Reduced specialized processing in psychotic disorder: a graph theoretical analysis of cerebral functional connectivity

et al. 2016

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BackgroundPrevious research has shown that the human brain can be represented as a complex functional network that is characterized by specific topological properties, such as clustering coefficient, characteristic path length, and global/local efficiency. Patients with psychotic disorder may have alterations in these properties with respect to controls, indicating altered efficiency of network organization. This study examined graph theoretical changes in relation to differential genetic risk for the disorder and aimed to identify clinical correlates.MethodsAnatomical and resting‐state MRI brain scans were obtained from 73 patients with psychotic disorder, 83 unaffected siblings, and 72 controls. Topological measures (i.e., clustering coefficient, characteristic path length, and small‐worldness) were used as dependent variables in a multilevel random regression analysis to investigate group differences. In addition, associations with (subclinical) psychotic/cognitive symptoms were examined.ResultsPatients had a significantly lower clustering coefficient compared to siblings and controls, with no difference between the latter groups. No group differences were observed for characteristic path length and small‐worldness. None of the topological properties were associated with (sub)clinical psychotic and cognitive symptoms.ConclusionsThe reduced ability for specialized processing (reflected by a lower clustering coefficient) within highly interconnected brain regions observed in the patient group may indicate state‐related network alterations. There was no evidence for an intermediate phenotype and no evidence for psychopathology‐related alterations.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

“…2008; Yu et al. 2011) but there are also reports of shorter path length and higher global efficiency (Alexander‐Bloch et al. 2010; Lynall et al.…”

Section: Introductionmentioning

confidence: 99%

“…2010; Yu et al. 2011). Two of these studies did not find an association between topological measures and clinical correlates, but Yu et al.…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Reduced specialized processing in psychotic disorder: a graph theoretical analysis of cerebral functional connectivity

et al. 2016

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ANK3 as a risk gene for schizophrenia: New data in han Chinese and meta analysis

Yuan

Wang

et al. 2012

American J of Med Genetics Pt B

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Histological and neuroimaging evidence supports the hypothesis that neuronal disconnectivity may be involved in the pathogenesis of schizophrenia. A genome-wide association study (GWAS) showed a single nucleotide polymorphism (SNP), rs10761482 in ankyrin 3 (ANK3), a major neuron-enriched gene, was associated with schizophrenia although inconsistent results had been reported. Two meta analyses reported another SNP rs10994336 in ANK3 gene confers risk to bipolar disorder (BD). Due to evidence of genetic overlap between schizophrenia and BD, we investigated common findings by analyzing the association of ANK3 polymorphisms (rs10761482, rs10994336, and two missenses, rs3808942 and rs3808943) with schizophrenia, using the Han Chinese population. A total of 516 schizophrenia cases, 400 controls, and 81 trios of early onset schizophrenia were recruited for association studies. Furthermore, the published datasets were combined with our results to determine the effect of the loci on schizophrenia. Our association study showed the frequencies of C allele of rs10761482 and T allele of rs10994336 were higher in patients than in controls. Furthermore, allele condition analyses indicated the association signal observed at rs10761482 and rs10994336 was independent. A haplotype analysis revealed the rs10761482-rs3808942-rs3808943 haplotype was associated with schizophrenia. The frequency of the T-T-T haplotype was higher in patients than in controls. In the transmission disequilibrium test analysis, the C allele of rs10761482 and the rs10761482-rs3808942-rs3808943 haplotype were preferentially transmitted in the trios. Meta analysis incorporating previous and current studies also showed rs10761482 and rs10994336 were associated with schizophrenia. We conclude that ANK3 gene has a major influence on susceptibility to schizophrenia across populations.

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Relations between structural and EEG‐based graph metrics in healthy controls and schizophrenia patients

Gómez‐Pilar

Luis‐García

Lubeiro

et al. 2018

Human Brain Mapping

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Our aim was to assess structural and functional networks in schizophrenia patients; and the possible prediction of the latter based on the former. The possible dependence of functional network properties on structural alterations has not been analyzed in schizophrenia. We applied averaged path-length (PL), clustering coefficient, and density (D) measurements to data from diffusion magnetic resonance and electroencephalography in 39 schizophrenia patients and 79 controls. Functional data were collected for the global and theta frequency bands during an odd-ball task, prior to stimulus delivery and at the corresponding processing window. Connectivity matrices were constructed from tractography and registered cortical segmentations (structural) and phase-locking values (functional). Both groups showed a significant electroencephalographic task-related modulation (change between prestimulus and response windows) in the global and theta bands. Patients showed larger structural PL and prestimulus density in the global and theta bands, and lower PL task-related modulation in the theta band. Structural network values predicted prestimulus global band values in controls and global band task-related modulation in patients. Abnormal functional values found in patients (prestimulus density in the global and theta bands and task-related modulation in the theta band) were not predicted by structural data in this group. Structural and functional network abnormalities respectively predicted cognitive performance and positive symptoms in patients. Taken together, the alterations in the structural and functional theta networks in the patients and the lack of significant relations between these alterations, suggest that these types of network abnormalities exist in different groups of schizophrenia patients.

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Altered Topological Properties of Functional Network Connectivity in Schizophrenia during Resting State: A Small-World Brain Network Study

Cited by 129 publications

References 91 publications

Reduced specialized processing in psychotic disorder: a graph theoretical analysis of cerebral functional connectivity

Reduced specialized processing in psychotic disorder: a graph theoretical analysis of cerebral functional connectivity

ANK3 as a risk gene for schizophrenia: New data in han Chinese and meta analysis

Relations between structural and EEG‐based graph metrics in healthy controls and schizophrenia patients

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