Altered task modulation of global signal topography in the default-mode network of unmedicated major depressive disorder

Lu, Xiang; Zhang, Jianfeng; Gu, Feng; Zhang, Hongxing; Zhang, Meng; Zhang, Haisan; Song, Ruize; Shi, Yachen; Li, Kun; Bi, Wang; Zhang, Zhijun; Northoff, Georg

doi:10.1016/j.jad.2021.09.093

Cited by 19 publications

(12 citation statements)

References 45 publications

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“…Increased global signal representation of the mental and exteroceptive self in post-acute MDD We observed increased global signal representation in specifically the regions of the mental and exteroceptive self like CMS and TPJ using both selected regions related to the self and a more general anatomical template (glasser atlas). This is well consistent with previous studies showing abnormal global brain activity in these regions during both rest [12] and task [23] in acute MDD. Our results confirm the abnormal global activity representation which is further supported by the disappearance of these differences when conducting global signal regression.…”

Section: Discussionsupporting

confidence: 93%

“…A recent study investigated the brain's global activity (global signal) in fMRI resting state and observed abnormally increased representation of the global signal in specifically the CMS of acute MDD compared to their non-CMS regions [12]. This was complemented by another study showing decreased representation of global brain activity in acute MDD during task-related activity (emotion x speed interaction) in CMS [23]. While these findings hint towards a relationship of altered global brain activity in CMS with the increased self-focus in MDD, they nevertheless leave open (i) the relationship of global brain activity in specifically CMS with the self in MDD; (ii) how that modulates other functions like abnormal emotion regulation [24] in these subjects.…”

Section: Introductionmentioning

confidence: 95%

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Abnormal global signal topography of self modulates emotion dysregulation in major depressive disorder

et al. 2023

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Major depressive disorder (MDD) is a complex mental disorder featured by an increased focus on the self and emotion dysregulation whose interaction remains unclear, though. At the same time, various studies observed abnormal representation of global fMRI brain activity in specifically those regions, e.g., cortical midline structure (CMS) in MDD that are associated with the self. Are the self and its impact on emotion regulation related to global brain activity unevenly represented in CMS relative to non-CMS? Addressing this yet open question is the main goal of our study. We here investigate post-acute treatment responder MDD and healthy controls in fMRI during an emotion task involving both attention and reappraisal of negative and neutral stimuli. We first demonstrate abnormal emotion regulation with increased negative emotion severity on the behavioral level. Next, focusing on a recently established three-layer topography of self, we show increased representation of global fMRI brain activity in specifically those regions mediating the mental (CMS) and exteroceptive (Right temporo-parietal junction and mPFC) self in post-acute MDD during the emotion task. Applying a complex statistical model, namely multinomial regression analyses, we show that increased global infra-slow neural activity in the regions of the mental and exteroceptive self modulates the behavioral measures of specifically negative emotion regulation (emotion attention and reappraisal/suppression). Together, we demonstrate increased representation of global brain activity in regions of the mental and exteroceptive self, including their modulation of negative emotion dysregulation in specifically the infra-slow frequency range (0.01 to 0.1 Hz) of post-acute MDD. These findings support the assumption that the global infra-slow neural basis of the increased self-focus in MDD may take on the role as basic disturbance in that it generates the abnormal regulation of negative emotions.

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 95%

Abnormal global signal topography of self modulates emotion dysregulation in major depressive disorder

et al. 2023

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“…Clinically, MDD is characterized by increased internally-oriented cognition like mind wandering, i.e., rumination, and selfreferential thought which are typically associated with increased regional/network activity in default-mode network (DMN). Various fMRI findings observe abnormal GS correlation to the regions in DMN regions like medial prefrontal cortex and hippocampus during resting state [87][88][89][90][91][92] and task-related activity 93 , which correlates with depressive symptoms 91 and predicts treatment response 92 .…”

Section: Used Beta Value In Gs Regression While the Other Studies Emp...mentioning

confidence: 99%

Beyond noise to function: reframing the global brain activity and its dynamic topography

Zhang

Northoff

2022

Commun Biol

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How global and local activity interact with each other is a common question in complex systems like climate and economy. Analogously, the brain too displays ‘global’ activity that interacts with local-regional activity and modulates behavior. The brain’s global activity, investigated as global signal in fMRI, so far, has mainly been conceived as non-neuronal noise. We here review the findings from healthy and clinical populations to demonstrate the neural basis and functions of global signal to brain and behavior. We show that global signal (i) is closely coupled with physiological signals and modulates the arousal level; and (ii) organizes an elaborated dynamic topography and coordinates the different forms of cognition. We also postulate a Dual-Layer Model including both background and surface layers. Together, the latest evidence strongly suggests the need to go beyond the view of global signal as noise by embracing a dual-layer model with background and surface layer.

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“…Finally, extending beyond the occipital cortex and its visual perception, reduced dynamics can also be observed in other domains or functions like cognition [56], emotion [57], and action/movements [32] in MDD -these are all featured by reduced ability to process higher dynamic information. Reduced dynamics may thus be a strong candidate for a "basic disturbance" in MDD that underlies and generates the various symptoms (in their respective domains) [58].…”

Section: Discussionmentioning

confidence: 99%

“…Whether occipital cortex changes are related to the reduced dynamics of visual perception and other psychopathological symptoms remains yet unclear. Moreover, how occipital cortical changes in uence changes in higher-order brain regions dysfunctional in MDD, such as perigenual anterior cingulate cortex (PACC), default-mode network (DMN), and lateral prefrontal cortex [11][12][13][14][15][16][17][18][19][28][29][30][31][32][33], is not yet clear. To unravel this issue, we aim to investigate the dynamics of occipital cortex function on perceptual and neural levels in three independents acute MDD data sets.…”

Section: Introductionmentioning

confidence: 99%

Why am I lagging? Reduced dynamics of perception and occipital cortex in depression

Song

Gao

Yong

et al. 2023

Preprint

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Major depressive disorder (MDD) is characterized by reduced dynamic with abnormal slowness in emotion, thought/cognition, and movements. Is the reduced dynamic also manifest in visual perception and neural activity of occipital cortex? Various findings show reduced activity in occipital cortex including in subareas like human MT complex (hMT+) cortex in MDD; its meaning for the dynamics of visual perception in MDD remains yet unclear, though. Combining novel data in three independents acute MDD samples (totally, 109 MDD, 113 HC), we characterize hMT+ in MDD in a dynamic way on perceptual (visual motion paradigm) and neural (rest/task fMRI) levels. Our main findings in MDD are: (i) reduced duration threshold difference for discriminating fast and slow-speed stimuli, leading to (ii) the perception of a longer distance for faster-speed moving gratings; (iii) reduced global representation of the brain’s spontaneous activity in hMT+ in especially faster infra slow frequencies with reverberation to subcortical and higher-order cortical regions; (iv) reduced beta value in hMT+ and higher-order cortical regions to especially faster visual stimuli; (v) correlation of these psychophysical and neural changes with symptom severity. We demonstrate reduced occipital activity in faster timescales on perceptual, and neural levels. Occipital cortex (hMT+) activity in MDD is characterized by reduced dynamics which shapes these subjects’ visual perception in an abnormal way. Beyond further establishing a basic dynamic deficit characterizing the visual system in MDD on both neural and perceptual levels, our results provide clinical opportunities for occipital-based diagnostic markers and novel therapeutic interventions in MDD.

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Altered task modulation of global signal topography in the default-mode network of unmedicated major depressive disorder

Cited by 19 publications

References 45 publications

Abnormal global signal topography of self modulates emotion dysregulation in major depressive disorder

Abnormal global signal topography of self modulates emotion dysregulation in major depressive disorder

Beyond noise to function: reframing the global brain activity and its dynamic topography

Why am I lagging? Reduced dynamics of perception and occipital cortex in depression

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