volume 8, issue 12, P3356-3374 2016
DOI: 10.18632/aging.101125
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Ching-Jung Huang, Utsab Das, Weijun Xie, Miryam Ducasse, Haley O. Tucker

Abstract: While cellular senescence is a critical mechanism to prevent malignant transformation of potentially mutated cells, persistence of senescent cells can also promote cancer and aging phenotypes. NonO/p54nrb and PSF are multifunctional hnRNPs typically found as a complex exclusively within the nuclei of all mammalian cells. We demonstrate here that either increase or reduction of expression of either factor results in cellular senescence. Coincident with this, we observe expulsion of NonO and PSF-containing nucle…

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