Altered spontaneous activity in antisocial personality disorder revealed by regional homogeneity

Tang, Yan; Liu, Wangyong; Chen, Jingang; Jian, Lin; Hu, Dewen; Wang, Wei

doi:10.1097/wnr.0b013e3283627993

Cited by 15 publications

(12 citation statements)

References 23 publications

(26 reference statements)

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“…Tang et al (131) investigated resting-state neural activity in ASPD and found that ASPD subjects showed decreased activity in the posterior cerebellum and middle frontal gyrus (MFG). Contrariwise, ASPD subjects showed increased activity in the middle occipital gyrus, inferior temporal gyrus, and inferior occipital gyrus (130). Similarly, Liu, Liao, Jiang, and Wang (132) found decreased activity in the posterior cerebellum, but also in temporal areas and in the orbitofrontal cortex.…”

Section: Functional Mri Findings In Aspdmentioning

confidence: 82%

“…These heritable disorders reflect independent structural and functional aberrancies in the brain, but also seem to manifest convergent biological processes to some extent. For example, both CD and ASPD are related to dysfunction of the default mode network (93,130) and to decreased GMV in limbic and cortical regions (31,128). Further, the said disorders are not mutually exclusive nor are they biologically dichotomic constructs.…”

Section: Discussionmentioning

confidence: 99%

“…Both the volume of the anterior cingulate cortex and that of the right thalamus negatively correlated with psychosocial deprivation (126,129). Moreover, increased GMV and WMV were found in ASPD subjects in the inferior parietal lobule and precuneus, respectively (130). However, a study by Howner et al (34) showed that ASPD individuals had a decreased global brain volume compared to healthy controls.…”

Section: Structural Gray Matter Findings In Aspdmentioning

confidence: 99%

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A Systematic Literature Review of Neuroimaging of Psychopathic Traits

et al. 2020

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Introduction: Core psychopathy is characterized by grandiosity, callousness, manipulativeness, and lack of remorse, empathy, and guilt. It is often comorbid with conduct disorder and antisocial personality disorder (ASPD). Psychopathy is present in forensic as well as prison and general populations. In recent years, an increasing amount of neuroimaging studies has been conducted in order to elucidate the obscure neurobiological etiology of psychopathy. The studies have yielded heterogenous results, and no consensus has been reached.Aims: This study systematically reviewed and qualitatively summarized functional and structural neuroimaging studies conducted on individuals with psychopathic traits. Furthermore, this study aimed to evaluate whether the findings from different MRI modalities could be reconciled from a neuroanatomical perspective.Materials and Methods: After the search and auditing processes, 118 neuroimaging studies were included in this systematic literature review. The studies consisted of structural, functional, and diffusion tensor MRI studies.Results: Psychopathy was associated with numerous neuroanatomical abnormalities. Structurally, gray matter anomalies were seen in frontotemporal, cerebellar, limbic, and paralimbic regions. Associated gray matter volume (GMV) reductions were most pronounced particularly in most of the prefrontal cortex, and temporal gyri including the fusiform gyrus. Also decreased GMV of the amygdalae and hippocampi as well the cingulate and insular cortices were associated with psychopathy, as well as abnormal morphology of the hippocampi, amygdala, and nucleus accumbens. Functionally, psychopathy was associated with dysfunction of the default mode network, which was also linked to poor moral judgment as well as deficient metacognitive and introspective abilities. Second, reduced white matter integrity in the uncinate fasciculus and dorsal cingulum were associated with core psychopathy. Third, emotional detachment was associated with dysfunction of the posterior cerebellum, the human mirror neuron system and the Theory of Mind denoting lack of empathy and persistent failure in integrating affective information into cognition.Conclusions: Structural and functional aberrancies involving the limbic and paralimbic systems including reduced integrity of the uncinate fasciculus appear to be associated with core psychopathic features. Furthermore, this review points towards the idea that ASPD and psychopathy might stem from divergent biological processes.

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Section: Functional Mri Findings In Aspdmentioning

confidence: 82%

Section: Discussionmentioning

confidence: 99%

Section: Structural Gray Matter Findings In Aspdmentioning

confidence: 99%

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A Systematic Literature Review of Neuroimaging of Psychopathic Traits

et al. 2020

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“…Mounting evidence indicates that these abnormalities are related to deficits in the prefrontal cortex, temporal cortex, insula, angular gyrus, parahippocampus, and anterior/posterior cingulate gyrus. In our previous studies, we investigated ASPD-related changes in the regional homogeneity (ReHo) by using resting-state functional MRI (R-fMRI) data, and we found that the ASPD individuals show reduced ReHo in the middle frontal gyrus and elevated ReHo in the inferior temporal gyrus 3 . In another functional connectivity study 4 , we determined that ASPD-associated changes occur primarily within and across the default-mode network (DMN).…”

mentioning

confidence: 99%

Aberrant functional brain connectome in people with antisocial personality disorder

Tang

Long

Wang

et al. 2016

Sci Rep

Self Cite

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Antisocial personality disorder (ASPD) is characterised by a disregard for social obligations and callous unconcern for the feelings of others. Studies have demonstrated that ASPD is associated with abnormalities in brain regions and aberrant functional connectivity. In this paper, topological organisation was examined in resting-state fMRI data obtained from 32 ASPD patients and 32 non-ASPD controls. The frequency-dependent functional networks were constructed using wavelet-based correlations over 90 brain regions. The topology of the functional networks of ASPD subjects was analysed via graph theoretical analysis. Furthermore, the abnormal functional connectivity was determined with a network-based statistic (NBS) approach. Our results revealed that, compared with the controls, the ASPD patients exhibited altered topological configuration of the functional connectome in the frequency interval of 0.016–0.031 Hz, as indicated by the increased clustering coefficient and decreased betweenness centrality in the medial superior frontal gyrus, precentral gyrus, Rolandic operculum, superior parietal gyrus, angular gyrus, and middle temporal pole. In addition, the ASPD patients showed increased functional connectivity mainly located in the default-mode network. The present study reveals an aberrant topological organisation of the functional brain network in individuals with ASPD. Our findings provide novel insight into the neuropathological mechanisms of ASPD.

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“…The MTG exhibited the highest discriminate power within the DMN to distinguish individuals with antisocial personality disorder from controls and the cerebellum enabled the best differentiation overall (Tang, Jiang, et al , 2013). For the MTG, other rs-fMRI studies reported increased functional activity in adults with antisocial personality disorder (Tang, Liu, et al , 2013) and CU-related decreased rsFC in prison inmates (Espinoza et al , 2018). Cerebellar and opercular regions have been implicated in CU-related rsFC alterations in adults (Philippi et al , 2015) and juveniles (Aghajani et al , 2016) and left insula in CU-related rsFC (Werhahn et al , 2018), emotions (Lindquist et al , 2012), and empathy (Lockwood et al , 2013).…”

Section: Discussionmentioning

confidence: 97%

Different Whole-Brain Functional Connectivity Correlates of Reactive-Proactive Aggression and Callous-Unemotional Traits in Disruptive Children and Adolescents

Werhahn

Mohl

Willinger

et al. 2019

Preprint

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Background. Disruptive behavior in children and adolescents can manifest itself in reactive (RA) and proactive (PA) aggression and is modulated by callous-unemotional (CU) traits and comorbidity. Research on aggression subtype-specific neural correlates is limited and the role of comorbid symptoms largely neglected.Methods. The current multi-center study extended previous efforts by investigating unrestricted resting state functional connectivity (rsFC) alterations. The large sample (n = 207) of children and adolescents aged 8 -18 years (mean age = 13.30 ± 2.60 years) included 118 cases with disruptive behavior (80 diagnosed with Oppositional Defiant Disorder and/or Conduct Disorder) and 89 controls. Attention-deficit/hyperactivity disorder (ADHD) and anxiety symptoms were added as covariates. We measured changes in global and local voxelto-voxel rsFC using functional magnetic resonance imaging at 3T (mean acquisition time = 8 min 25 sec).Results. Compared to controls, cases demonstrated altered rsFC including frontal areas when anxiety but not ADHD symptoms were considered. Within cases, RA and PA scores related to changes in global and local rsFC in central gyrus and precuneus previously linked to aggression-related impairments. CU trait severity correlated with global rsFC alterations including inferior and middle temporal gyrus implicated in empathy, emotion, and rewardrelated activity. Importantly, most observed aggression subtype-specific patterns could only be identified when ADHD and anxiety problems were also accounted for.Conclusions. The current study clarifies that distinct though overlapping brain connectivity measures can disentangle differing manifestations of aggressive behavior. Moreover, our results highlight the importance of considering comorbid symptoms for detecting aggressionrelated rsFC alterations. Werhahn et al. 5

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Altered spontaneous activity in antisocial personality disorder revealed by regional homogeneity

Cited by 15 publications

References 23 publications

A Systematic Literature Review of Neuroimaging of Psychopathic Traits

A Systematic Literature Review of Neuroimaging of Psychopathic Traits

Aberrant functional brain connectome in people with antisocial personality disorder

Different Whole-Brain Functional Connectivity Correlates of Reactive-Proactive Aggression and Callous-Unemotional Traits in Disruptive Children and Adolescents

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