Abstract:Following a bleach, both genetic and streptozotocin diabetic mice exhibited abnormalities in rhodopsin regeneration. When studied at moderate bleaching levels with animals that were moderately diabetic, both groups of diabetic mice exhibited a delay in the start of the rhodopsin regeneration. The delay appears to be caused by the formation of an acid intermediate of the bleached rhodopsin resulting from acid conditions within the rod photoreceptors.
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