Altered Response to and Production of TGF-β by B Cells from Autoimmune NZB Mice

Douglas, Raymond S.; Woo, Edward Y.; Capocasale, Renold J.; Tarshis, Adam D.; Nowell̀, Peter C.; Moore, Jonni S.

doi:10.1006/cimm.1997.1149

Cited by 17 publications

(7 citation statements)

References 66 publications

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“…The components of the regulatory B cell system are similar to those of regulatory T cells, including Type I IL-10- producing regulatory T cells (Tr1), Type III TGF-β-producing helper T cells (Th3), and Treg. TGF-β induces apoptosis in CD5 + B cells,37 and IL-10 enhances the proliferation of CD5 + cells in an autocrine manner 40. Reciprocal effects of IL-10 from Br1 and TGF-β from Br3 are shown in Fig.…”

Section: Advances In Regulatory B Cells and Their Nomenclature: Il-10mentioning

confidence: 85%

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Regulatory B Cells and Allergic Diseases

Noh

Lee

2011

Allergy Asthma Immunol Res

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B cells are generally considered to positively regulate immune responses by producing antigen-specific antibodies. B cells are classified into classical CD5- conventional B cells and CD5+ B1 cells. The latter produce multi-specific autoantibodies and are thought to be involved in autoimmune diseases. However, evidence supporting a B cell negative regulatory function has accumulated over the past 30 years. Multiple reports have suggested that absence, or loss, of regulatory B cells exacerbates symptoms of both allergic (including contact hypersensitivity and anaphylaxis) and autoimmune (such as experimental autoimmune encephalomyelitis, chronic colitis, and collagen-induced arthritis) diseases, and in lupus-like models of autoimmunity. Regulatory B cells are characterized by production of the negative regulatory cytokines, IL-10 and TGF-β. IL-10-producing B cells were the first regulatory B cells to be recognized and were termed 'B10' cells. IL-10-producing regulatory B cells are of the CD19+CD5+IgMhiIgDloCD1dhi type. Recently, a TGF-β-producing regulatory B cell subset, Br3, has been shown to be related to immune tolerance in food allergies. Moreover, forkhead box P3 (Foxp3)-expressing B cells have also been identified in humans and may act as regulatory B cells (Bregs). The functional image of regulatory B cells is similar to that of regulatory T cells. Because of the proliferative and apoptotic responses of Br1 and Br3 cells in immune tolerance in non-IgE-mediated food allergy, reciprocal roles and counter-regulatory mechanisms of Br1 and Br3 responses are also suspected. Additionally, different roles for regulatory B and T cells at different time points during initiation and progression of autoimmune disease are described.

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Section: Advances In Regulatory B Cells and Their Nomenclature: Il-10mentioning

confidence: 85%

“…Another regulatory B cell subset that produces transforming growth factor-β (TGF-β) after stimulation with LPS has been also identified 36. TGF-β is produced by both CD5 + and CD5 - B cells from autoimmune-prone NZB mice,37 and is also expressed by normal human B cells 38…”

Section: Advances In Regulatory B Cells and Their Nomenclature: Il-10mentioning

confidence: 99%

Regulatory B Cells and Allergic Diseases

Noh

Lee

2011

Allergy Asthma Immunol Res

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“…BREGS are involved in immunomodulation and suppression of the immune response through a range of mechanisms. The roles of BREGS have been studied in mouse models of autoimmune diseases including SLE ( 38 ) and experimental autoimmune encephalomyelitis ( 21 ). However, there is no clear understanding of the characteristics of BREGS ( 39 ).…”

Section: Discussionmentioning

confidence: 99%

Aberrant expression of interleukin-10 and activation-induced cytidine deaminase in B cells from patients with Beh?et's disease

Yoon

Lee

et al. 2017

biom rep

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Despite extensive studies, the pathogenesis of Behçet's disease (BD) remains unclear. In particular, the roles of B cells in patients with BD have not been elucidated. Activation-induced cytidine deaminase (AID) is a critical enzyme for immunoglobulin (Ig) heavy chain class switching and somatic hypermutation in B cells and the abnormal expression of AID in various immune conditions has previously been studied. B10 cells, an interleukin (IL)-10-secreting subset of regulatory B cells, function to downregulate inflammation and autoimmunity. Thus, in the present study, the relevance of B cells in patients with BD was investigated. The plasma levels of IL-10 and IgA and the proportions of cluster of differentiation (CD)43+ B cells, excluding naïve B cells, were measured in 16 patients with BD and 16 age- and sex-matched healthy controls (HCs). Additionally, the mRNA levels of IL-10 and AID were assessed in B cells from fresh peripheral blood samples of the BD patients and HCs. The plasma level of IL-10 in patients with BD did not differ significantly from that in HCs. Similarly, there was no significant difference in the plasma level of IgA, although a slight increase was observed in patients with BD compared with that in HCs. There were no differences in CD43+CD19+ B cell numbers between patients with BD and HCs. However, IL-10 mRNA levels were significantly reduced (P<0.05), while AID mRNA levels were significantly increased (P<0.01) in the B cells of patients with BD compared with those in HCs. These results provide insight into the role of B cells in patients with BD.

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“…Through TGF-b production, lipopolysaccharide (LPS)-activated B cells can induce apoptosis of CD4 + [18] and anergy in CD8 + [19] effector T cells. TGF-b is produced by both CD5 + and CD5 -B cells from autoimmune-prone NZB mice [20] and it is also expressed by normal human B cells [21]. These TGF-b + B cells play essential roles in the induction of tolerance to non-IgE mediated food allergy in atopic dermatitis [21].…”

Section: Regulatory B Cells: Phenotypes and Suppression Mechanismsmentioning

confidence: 99%

The regulatory role of B cells in autoimmunity, infections and cancer: Perspectives beyond IL10 production

et al. 2015

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a b s t r a c tThe term regulatory B cells (B regs) is ascribed to a heterogeneous population of B cells with the function of suppressing inflammatory responses. They have been described mainly during the last decade in the context of different immune-mediated diseases. Most of the work on B regs has been focused on IL-10-producing B cells. However, B cells can exert regulatory functions independently of IL-10 production. Here we discuss the phenotypes, development and effector mechanisms of B regs and advances in their role in autoimmunity, infections and cancer.

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Altered Response to and Production of TGF-β by B Cells from Autoimmune NZB Mice

Cited by 17 publications

References 66 publications

Regulatory B Cells and Allergic Diseases

Regulatory B Cells and Allergic Diseases

Aberrant expression of interleukin-10 and activation-induced cytidine deaminase in B cells from patients with Beh?et's disease

The regulatory role of B cells in autoimmunity, infections and cancer: Perspectives beyond IL10 production

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