Altered regional grey matter volume and appetite-related hormone levels in adolescent obesity with or without binge-eating disorder

Turan, Serkan; Sarıoğlu, Fatma Ceren; Çavuşoğlu, Berrin; Karagöz, Ezgi; Şişman, Ali Rιza; Güney, Sevay Alşen; Güleryüz, Handan; Abacı, Ayhan; Öztürk, Yeşim; Akay, Aynur Pekcanlar

doi:10.1007/s40519-021-01117-4

Cited by 16 publications

(15 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Previous investigations comparing brain structure in persons with and without binge eating are sparse and results are mixed. Although some have reported alterations in regional volumes in persons with et Frank et al, 2013;Schäfer et al, 2010;Turan et al, 2021), others have not (Berner et al, 2019;Joos et al, 2010).…”

Section: Discussionmentioning

confidence: 99%

“…We did not observe differences in average regional volume and thickness between girls and women with and without binge eating. et Frank et al, 2013;Schäfer et al, 2010;Turan et al, 2021), others have not (Berner et al, 2019;Joos et al, 2010).…”

Section: Discussionmentioning

confidence: 99%

“…Previous investigations comparing brain structure in persons with and without binge eating are sparse and results are mixed. Although some have reported alterations in regional volumes in persons with BED and BN (Abdo et al, 2020; Amianto et al, 2013; Coutinho et al, 2015; Frank et al, 2013; Schäfer et al, 2010; Turan et al, 2021), others have not (Berner et al, 2019; Joos et al, 2010). Our results align with findings that suggest no regional volumetric alterations in persons with binge eating relative to their healthy counterparts.…”

Section: Discussionmentioning

confidence: 99%

“…A handful of cross‐sectional studies have found increased nucleus accumbens (Abdo, Boyd, Baboumian, Pantazatos, & Geliebter, 2020), medial orbitofrontal cortex (Schäfer, Vaitl, & Schienle, 2010; Turan et al, 2021), and anterior cingulate cortex (Schäfer et al, 2010) volume in adults with BED compared to adults without BED. In BN, studies have suggested alterations in brain volume in adults who are acutely ill (Amianto et al, 2013; Coutinho et al, 2015; Frank, Shott, Hagman, & Mittal, 2013; Schäfer et al, 2010) or remitted (Wagner et al, 2006) from the disorder.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Subcortical brain volume and cortical thickness in adolescent girls and women with binge eating

Hagan¹,

Bohon

2021

Intl J Eating Disorders

View full text Add to dashboard Cite

Objective: Alterations in brain structure have been implicated in the onset and acute phases of several forms of psychopathology. However, there is a dearth of research investigating brain structure in persons with binge eating, contributing to poor understanding of mechanisms associated with binge eating.Method: Adolescent girls and women (aged 14-35 years) with binge eating (n = 56) and group age-matched girls and women without binge eating (n = 26) completed structural magnetic resonance imaging (MRI) scans and interview-based and selfreport assessments of eating disorder and general psychopathology. MRI data were processed using FreeSurfer. Analysis of covariance tested mean differences in subcortical volume and cortical thickness of a priori selected regions of interest between binge-eating and non-binge-eating groups, controlling for age, body mass index, purging frequency, depression, and medication use. Exploratory partial correlations tested associations between brain structure and eating disorder symptoms within participants with binge eating. Results:We did not observe differences in regional subcortical volume and cortical thickness between girls and women with and without binge eating. Within participants with binge eating, severity of attitudinal eating disorder symptoms was inversely associated with caudal middle frontal gyrus, right precentral gyrus, right postcentral gyrus, superior parietal, left inferior parietal thickness, and left accumbens volume; however, these associations would not survive multiple-comparison corrections.Discussion: Correlations between attitudinal eating disorder symptoms and frontoparietal thinning may represent a state marker of binge eating. Future research could investigate whether frontoparietal thinning worsens with illness duration or persists beyond binge eating cessation.

show abstract

“…Previous investigations comparing brain structure in persons with and without binge eating are sparse and results are mixed. Although some have reported alterations in regional volumes in persons with et Frank et al, 2013;Schäfer et al, 2010;Turan et al, 2021), others have not (Berner et al, 2019;Joos et al, 2010).…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…Previous investigations comparing brain structure in persons with and without binge eating are sparse and results are mixed. Although some have reported alterations in regional volumes in persons with BED and BN (Abdo et al, 2020; Amianto et al, 2013; Coutinho et al, 2015; Frank et al, 2013; Schäfer et al, 2010; Turan et al, 2021), others have not (Berner et al, 2019; Joos et al, 2010). Our results align with findings that suggest no regional volumetric alterations in persons with binge eating relative to their healthy counterparts.…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Subcortical brain volume and cortical thickness in adolescent girls and women with binge eating

Hagan¹,

Bohon

2021

Intl J Eating Disorders

View full text Add to dashboard Cite

show abstract

“…-Patients with AN-bp with lower levels of NAA or higher levels of glutamate displayed more automaticity in the instrumental learning task. higher volume of the medial/total OFC (n = 4, 29%), right ventral striatum/NAc (n = 2, 14%), left insula (n = 2, 14%), left postcentral gyrus (n = 2, 14%), and ACC (n = 2, 14%) (Amianto et al, 2013;Coutinho et al, 2014;Frank et al, 2013;Schäfer et al, 2010;Turan et al, 2021;Voon et al, 2015). There were two (14%) studies that followed participants longitudinally (Cyr et al, 2017;Zhang et al, 2021).…”

Section: Restmentioning

confidence: 99%

The neurobiological reward system and binge eating: A critical systematic review of neuroimaging studies

Leenaerts

Jongen

Ceccarini

et al. 2022

Intl J Eating Disorders

View full text Add to dashboard Cite

Objective Changes in reward processing are hypothesized to play a role in the onset and maintenance of binge eating (BE). However, despite an increasing number of studies investigating the neurobiological reward system in individuals who binge eat, no comprehensive systematic review exists on this topic. Therefore, this review has the following objectives: (1) identify structural and functional changes in the brain reward system, either during rest or while performing a task; and (2) formulate directions for future research. Methods A search was conducted of articles published until March 31, 2022. Neuroimaging studies were eligible if they wanted to study the reward system and included a group of individuals who binge eat together with a comparator group. Their results were summarized in a narrative synthesis. Results A total of 58 articles were included. At rest, individuals who binge eat displayed a lower striatal dopamine release, a change in the volume of the striatum, frontal cortex, and insula, as well as a lower frontostriatal connectivity. While performing a task, there was a higher activity of the brain reward system when anticipating or receiving food, more model‐free reinforcement learning, and more habitual behavior. Most studies only included one patient group, used general reward‐related measures, and did not evaluate the impact of comorbidities, illness duration, race, or sex. Discussion Confirming previous hypotheses, this review finds structural and functional changes in the neurobiological reward system in BE. Future studies should compare disorders, use measures that are specific to BE, and investigate the impact of confounding factors. Public Significance Statement This systematic review finds that individuals who binge eat display structural and functional changes in the brain reward system. These changes could be related to a higher sensitivity to food, relying more on previous experiences when making decisions, and more habitual behavior. Future studies should use a task that is specific to binge eating, look across different patient groups, and investigate the impact of comorbidities, illness duration, race, and sex.

show abstract

The interplay between white adipose tissue, adipokines, and structural gray matter changes

Okudzhava,

Schulz,

Pilorz

et al. 2024

Human Brain Mapping

View full text Add to dashboard Cite

The growing global obesity issue emphasizes the importance of understanding its health implications. Previous research has identified consistent alterations in gray matter (GM) volume in connection with obesity. Given the various implications of distinct fat compartments and the potential role of adipose tissue‐derived adipokines in brain health, a more detailed investigation of adiposity is required. This study investigates a sample of 65 males with varying body mass indices to explore the relationship between various fat compartments, adipokine levels, and volumetric GM variations, aiming to provide a deeper understanding of the interplay between adiposity, brain structure, and metabolic signals. Whole‐body magnetic resonance imaging (MRI) was used to assess total, visceral, and subcutaneous adipose tissue, while MR spectroscopy was performed to capture liver fat content. For the assessment of adipokine levels leptin and adiponectin concentrations were measured, and structural brain images underwent cortical and subcortical segmentation for GM volume and thickness. A predictive modeling approach with leave‐one‐out cross‐validation was used to predict body composition metrics and adipokine levels based on structural GM data. Our investigation revealed diminished GM volume and thickness correlated with elevated leptin levels in areas crucial for appetite regulation, decision‐making, and cognitive control, including the anterior insula, orbitofrontal cortex, and anterior cingulate cortex. These findings suggest a potential adverse impact of heightened leptin concentrations on brain health and eating habits. Contrary to expectations, our investigation found no significant relationship between GM volume and any of the measured fat compartments. This result prompts the need for further research to elucidate the relationship between obesity, adipokines, and brain structure.

show abstract

Altered regional grey matter volume and appetite-related hormone levels in adolescent obesity with or without binge-eating disorder

Cited by 16 publications

References 45 publications

Subcortical brain volume and cortical thickness in adolescent girls and women with binge eating

Subcortical brain volume and cortical thickness in adolescent girls and women with binge eating

The neurobiological reward system and binge eating: A critical systematic review of neuroimaging studies

The interplay between white adipose tissue, adipokines, and structural gray matter changes

Contact Info

Product

Resources

About