Altered regional activity and connectivity of functional brain networks in congenital unilateral conductive hearing loss

Yang, Tengyu; Liu, Qiang; Fan, Xinmiao; Hou, Bo; Wang, Jian; Chen, Xiaowei

doi:10.1016/j.nicl.2021.102819

Cited by 10 publications

(6 citation statements)

References 71 publications

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“…The inferior frontal gyrus has been implicated in various cognitive processes, including language production and executive functions (Hampshire et al, 2010;Ishkhanyan et al, 2020). Previous studies have reported similar intrinsic brain activity alterations in hearing loss patients (Zhou et al, 2019;Chen et al, 2020;Yang et al, 2021). For instance, Chen et al, (2020) found decreased static ALFF and fALFF in the auditory cortex and visual cortex in unilateral SSHL, and Zhou et al (2019) found abnormal static ALFF in the inferior frontal gyrus in unilateral acute tinnitus patients with hearing loss.…”

Section: Discussionmentioning

confidence: 67%

Altered static and dynamic intrinsic brain activity in unilateral sudden sensorineural hearing loss

Li,

Yu,

Zou

et al. 2023

Front. Neurosci.

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IntroductionSudden sensorineural hearing loss (SSHL) is a critical otologic emergency characterized by a rapid decline of at least 30 dB across three consecutive frequencies in the pure-tone audiogram within a 72-hour period. This audiological condition has been associated with alterations in brain cortical and subcortical structures, as well as changes in brain functional activities involving multiple networks. However, the extent of cerebral intrinsic brain activity disruption in SSHL remains poorly understood. The aimed of this study is to investigate intrinsic brain activity alterations in SSHL using static and dynamic fractional amplitude of low-frequency fluctuation (fALFF) analysis.MethodsResting-state functional magnetic resonance imaging (fMRI) data were acquired from a cohort of SSHL patients (unilateral, n = 102) and healthy controls (n = 73). Static and dynamic fALFF methods were employed to analyze the acquired fMRI data, enabling a comprehensive examination of intrinsic brain activity changes in SSHL.ResultsOur analysis revealed significant differences in static fALFF patterns between SSHL patients and healthy controls. SSHL patients exhibited decreased fALFF in the left fusiform gyrus, left precentral gyrus, and right inferior frontal gyrus, alongside increased fALFF in the left inferior frontal gyrus, left superior frontal gyrus, and right middle temporal gyrus. Additionally, dynamic fALFF analysis demonstrated elevated fALFF in the right superior frontal gyrus and right middle frontal gyrus among SSHL patients. Intriguingly, we observed a positive correlation between static fALFF in the left fusiform gyrus and the duration of hearing loss, shedding light on potential temporal dynamics associated with intrinsic brain activity changes.DiscussionThe observed disruptions in intrinsic brain activity and temporal dynamics among SSHL patients provide valuable insights into the functional reorganization and potential compensatory mechanisms linked to hearing loss. These findings underscore the importance of understanding the underlying neural alterations in SSHL, which could pave the way for the development of targeted interventions and rehabilitation strategies aimed at optimizing SSHL management.

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Section: Discussionmentioning

confidence: 67%

Altered static and dynamic intrinsic brain activity in unilateral sudden sensorineural hearing loss

Li,

Yu,

Zou

et al. 2023

Front. Neurosci.

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“…A contralateral transmission of the direct sound is also present with medium AC components, but at a lower level. Another possible explanation is a possible deprivation of the auditory pathway attributable to prolonged high-level conductive HL, especially with unusable conventional hearing aids prior to Osia fitting, such as in patients with auditory canal atresia [ 7 , 21 ]. Our results show a negative dependence of speech comprehension with Osia on ABG and thus they differ from those reported by Mylanus et al.…”

Section: Discussionmentioning

confidence: 99%

Prediction of postoperative speech comprehension with the transcutaneous partially implantable bone conduction hearing system Osia®

Arndt,

Wesarg,

Aschendorff

et al. 2023

HNO

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Background The active transcutaneous, partially implantable osseointegrated bone conduction system Cochlear™ Osia® (Cochlear, Sydney, Australia) has been approved for use in German-speaking countries since April 2021. The Osia is indicated for patients either having conductive (CHL) or mixed hearing loss (MHL) with an average bone conduction (BC) hearing loss of 55 dB HL or less, or having single-sided deafness (SSD). Objectives The aim of this retrospective study was to investigate the prediction of postoperative speech recognition with Osia® and to evaluate the speech recognition of patients with MHL and in particular an aided dynamic range of less than 30 dB with Osia®. Materials and methods Between 2017 and 2022, 29 adult patients were fitted with the Osia®, 10 patients (11 ears) with CHL and 19 patients (25 ears) with MHL. MHL was subdivided into two groups: MHL‑I with four-frequency pure-tone average in BC (BC-4PTA) ≥ 20 dB HL and < 40 dB HL (n = 15 patients; 20 ears) vs. MHL-II with BC-4PTA ≥ 40 dB HL (n = 4 patients; 5 ears). All patients tested a bone conduction hearing device on a softband preoperatively. Speech intelligibility in quiet was assessed preoperatively using the Freiburg monosyllabic test in unaided condition, with the trial BCHD preoperatively and with Osia® postoperatively with Osia®. The maximum word recognition score (mWRS) unaided and the word recognition score (WRS) with the test system at 65 dB SPL were correlated with the postoperative WRS with Osia® at 65 dB SPL. Results Preoperative prediction of postoperative outcome with Osia® was better using the mWRS than by the WRS at 65 dB SPL with the test device on the softband. Postoperative WRS was most predictive for patients with CHL and less predictable for patients with mixed hearing loss with BC-4PTA ≥ 40 dB HL. For the test device on a softband, the achievable outcome tended to a minimum, with the mWRS tending to predict the realistically achievable outcome. Conclusion Osia® can be used for the treatment of CHL and MHL within the indication limits. The average preoperative bone conduction hearing threshold also provides an approximate estimate of the postoperative WRS with Osia®, for which the most accurate prediction is obtained using the preoperative mWRS. Prediction accuracy decreases from a BC-4PTA of ≥ 40 dB HL.

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“…Although children with UCHL tend to have better school performance than those with SNHL, most of them still report communication and behavioral problems and need some sort of resource assistance [ 51 , 52 ]. Recently, a neuroimaging study has revealed abnormally high brain activities in the left inferior temporal gyrus of UCHL patients, which is positively associated with the duration of hearing loss [ 53 ]. This finding demonstrated that even partial hearing deprivations, such as UCHL can cause progressive alterations in functional brain networks.…”

Section: Discussionmentioning

confidence: 99%

The Effects of BCDs in Unilateral Conductive Hearing Loss: A Systematic Review

Wang,

Ren,

Xie

et al. 2023

JCM

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Bone conduction devices (BCDs) are widely used in the treatment of conductive hearing loss (CHL), but their applications on unilateral CHL (UCHL) patients remain controversial. To evaluate the effects of BCDs in UCHL, a systematic search was undertaken until May 2023 following the PRISMA guidelines. Among the 391 references, 21 studies met the inclusion criteria and were ultimately selected for review. Data on hearing thresholds, speech recognition, sound localization, and subjective questionnaire outcomes were collected and summarized. Moderate hearing threshold improvements were found in UCHL patients aided with BCDs. Their speech recognition abilities improved significantly. However, sound localization results showed wide individual variations. According to subjective questionnaires, BCDs had an overall positive influence on the daily life of UCHL patients, although several unfavorable experiences were reported by some of them. We concluded that the positive audiological benefits and subjective questionnaire results have made BCDs a credible intervention for UCHL patients. Before final implantations, UCHL patients should first go through a period of time when they were fitted with non-implantable BCDs as a trial.

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Altered regional activity and connectivity of functional brain networks in congenital unilateral conductive hearing loss

Cited by 10 publications

References 71 publications

Altered static and dynamic intrinsic brain activity in unilateral sudden sensorineural hearing loss

Altered static and dynamic intrinsic brain activity in unilateral sudden sensorineural hearing loss

Prediction of postoperative speech comprehension with the transcutaneous partially implantable bone conduction hearing system Osia®

The Effects of BCDs in Unilateral Conductive Hearing Loss: A Systematic Review

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