Altered prefrontal cortex activity during working memory task in Bipolar Disorder: A functional Magnetic Resonance Imaging study in euthymic bipolar I and II patients

Dell’Osso, Bernardo; Cinnante, Claudia; Giorgio, Annabella Di; Cremaschi, Laura; Palazzo, Carlotta; Cristoffanini, M.; Fazio, Leonardo; Dobrea, Cristina; Avignone, Sabrina; Triulzi, Fabio; Bertolino, Alessandro; Altamura, Alfredo Carlo

doi:10.1016/j.jad.2015.05.026

Cited by 39 publications

(23 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The present study offers a better characterization of the differences between the two main bipolar subgroups currently defined by DSM-5 60 in terms of clinical and sociodemographic features analyzed in an Italian sample. As recent genetic, epigenetic, and imaging studies have already shown specific differences in BDI vs II patients, [61][62][63] our findings provide further clinical support to the notion that BDI and BDII categories may be characterized by distinct profiles, rather than being simply considered two different expressions, in terms of severity, of the same entity. As such a perspective may have relevant repercussions on patients' prognosis and outcome, a better understanding of the differential characteristics of these phenotypic subtypes (ie, distinct phenotypes may be present within bipolar I and II subtypes and differentiated on the basis of specific features) may contribute to obtain more tailored pharmacological and psychosocial interventions.…”

Section: Resultssupporting

confidence: 82%

Italian Bipolar II vs I patients have better individual functioning, in spite of overall similar illness severity

et al. 2016

Self Cite

View full text Add to dashboard Cite

show abstract

Section: Resultssupporting

confidence: 82%

Italian Bipolar II vs I patients have better individual functioning, in spite of overall similar illness severity

et al. 2016

Self Cite

View full text Add to dashboard Cite

show abstract

“…Therefore, we have speculated that the changes in this neural circuit may be related to the pathophysiology of BD in females during adolescence and young adulthood. Additional support for our speculation has been shown in offspring (mean age = 13.8 years) of parents with BD who exhibit altered amygdala-PFC responses to facial emotion [ 19 ]. However, our results did not show any change in rs FC from the amygdala to the PFC in female patients with BD aged 26 to 45.…”

Section: Discussionsupporting

confidence: 72%

Age-specific effects of structural and functional connectivity in prefrontal-amygdala circuitry in women with bipolar disorder

Tang

Fan

et al. 2018

BMC Psychiatry

View full text Add to dashboard Cite

BackgroundBipolar disorder (BD) is a serious mental illness. Several studies have shown that brain structure and function changes and the development of BD are associated with age and sex differences. Therefore, we hypothesized that the functional and structural neural circuitry of BD patients would differ according to age. The amygdala and prefrontal cortex (PFC) are play a key role in the emotional and cognitive processing of patients with BD. In this study, we used magnetic resonance imaging (MRI) to examine the structural and functional connectivity within amygdala-PFC neural circuitry in women with BD at different ages.MethodsForty-nine female patients with BD who were aged 13–25 years and 60 age-matched healthy control (HC) individuals, as well as 43 female patients with BD who were aged 26–45 years and 60 age-matched HC individuals underwent resting-state functional MRI (rs-fMRI) and diffusion tensor imaging to examine the structural and functional connectivity within the amygdala-PFC neural circuitry.ResultsWe found abnormalities in the amygdala-PFC functional connectivity in patients aged 13–25 years and significantly different fractional anisotropy (FA) values in patients aged 26–45 compared with the age-matched HCs. The significance of these findings was indicated by corrected p values of less than 0.05 (uncorrected p values less than 0.001).ConclusionsThe findings in this cross-sectional study suggested that abnormalities in the functional connectivity of the amygdala-PFC neural circuitry are related to the pathophysiology of BD in women aged 13–25 years, while changes in the structural integrity of this neural circuitry are associated with the pathophysiology of BD in women aged 26–45 years. Therefore, functional and structural brain alterations may occur at different ages in female patients with BD.Electronic supplementary materialThe online version of this article (10.1186/s12888-018-1732-9) contains supplementary material, which is available to authorized users.

show abstract

“…It is now well established that cognitive impairment is one of the core features of mood disorders, emerging during depressive episodes in major depressive disorder (MDD) and during depressive and manic phases in bipolar disorder (BD). Moreover, there is evidence for the persistence of cognitive impairment beyond mood episodes during euthymia (Dell'Osso et al, 2015). A number of clinical characteristics has been associated with cognitive impairment in mood disorders and the severity of the impairment has been related to several clinical factors (McIntyre et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Duration of untreated illness and depression severity are associated with cognitive impairment in mood disorders

Galimberti

Bosi

Volontè

et al. 2020

International Journal of Psychiatry in Clinical Practice

View full text Add to dashboard Cite

Introduction: In this study we estimated the rate and the trajectory of cognitive impairment in a naturalistic sample of outpatients with major depressive disorder (MDD) and bipolar disorder (BD) and its correlation with different variables. Materials and methods: An overall sample of 109 outpatients with MDD or BD was assessed for multiple clinical variables, including duration of untreated illness (DUI), and tested using the Montreal Cognitive Assessment (MoCA) during Major Depressive Episodes (MDE) and after remission. Correlations between MoCA scores and the clinical variables were then computed. Results: About 50% of patients with MDD and BD showed mild cognitive impairment during MDE. Improvement of cognitive function between depression and remission was significant, even though residual symptoms were observed especially in the most impaired patients. Of note, cognitive performance during depression was negatively associated with depression severity and DUI. Discussion: Present findings confirm available evidence about patterns of cognitive impairment in mood disorders, in terms of prevalence and persistence beyond remission in most severe cases. Moreover, a longer DUI was associated with worse cognitive performance during depression, and consequently with poorer outcome, underlining the importance of prompt treatment of these disorders also in light of a cognitive perspective.

show abstract

Altered prefrontal cortex activity during working memory task in Bipolar Disorder: A functional Magnetic Resonance Imaging study in euthymic bipolar I and II patients

Cited by 39 publications

References 50 publications

Italian Bipolar II vs I patients have better individual functioning, in spite of overall similar illness severity

Italian Bipolar II vs I patients have better individual functioning, in spite of overall similar illness severity

Age-specific effects of structural and functional connectivity in prefrontal-amygdala circuitry in women with bipolar disorder

Duration of untreated illness and depression severity are associated with cognitive impairment in mood disorders

Contact Info

Product

Resources

About