2013
DOI: 10.4137/jen.s12979
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Abstract: Auto antibodies found in the mothers of children with autistic disorder (MCAD) when passively transferred to pregnant mice cause behavioral alterations in juvenile and adult offspring. The goal of this study was to identify whether intraperitoneal injection of MCAD-IgG during gestation affected postnatal cell proliferation and survival in P7 offspring. Pooled MCAD-IgG or IgG from mothers of unaffected children (MUC) or phosphate-buffered saline was injected daily into C57BL/J6 pregnant dams (gestational days E… Show more

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Cited by 9 publications
(6 citation statements)
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“…Experimental mice exposed to maternal autoantibodies in utero show increased cell proliferation during cortical neurogenesis [184, 229] and increased neuronal and brain size in adulthood [229]. In a similar model generated in rhesus monkeys, brain volume is increased [24], as has been described in children with autism born to mothers with the autoantibodies [259].…”
Section: Lessons From Animal Modelsmentioning
confidence: 99%
“…Experimental mice exposed to maternal autoantibodies in utero show increased cell proliferation during cortical neurogenesis [184, 229] and increased neuronal and brain size in adulthood [229]. In a similar model generated in rhesus monkeys, brain volume is increased [24], as has been described in children with autism born to mothers with the autoantibodies [259].…”
Section: Lessons From Animal Modelsmentioning
confidence: 99%
“…In particular, the maternal ASD IgG exposed mice exhibited impaired social interactions, a greater magnitude of startle response following acoustic stimulation, hyperactivity, and increased anxiety-like behaviors [50]. Furthermore, maternal ASD IgG exposure significantly increased cell proliferation in the subventricular (SVZ) and subgranular zones on postnatal day 7 (PD 7) [51]. Cell densities in layers 2–4 of the frontal and parietal cortices, however, were significantly decreased on PD 7 in mice prenatally exposed to maternal ASD IgG relative to controls [51].…”
Section: Identification Of Fetal Brain-reactive Maternal Autoantibodimentioning
confidence: 99%
“…Furthermore, maternal ASD IgG exposure significantly increased cell proliferation in the subventricular (SVZ) and subgranular zones on postnatal day 7 (PD 7) [51]. Cell densities in layers 2–4 of the frontal and parietal cortices, however, were significantly decreased on PD 7 in mice prenatally exposed to maternal ASD IgG relative to controls [51].…”
Section: Identification Of Fetal Brain-reactive Maternal Autoantibodimentioning
confidence: 99%
“…The distributed coordination function (DCF) and the delayed mode VR operation are proposed for wireless VR systems. (a) Wireless multiuser VR with conventional wireless local area networks (WLAN); (b) Wireless multiuser VR with delay-oriented WLAN mode (Kadam et al, 2013). Each MAC and PHY layer follows its own standards.…”
Section: Architecture and Protocolmentioning
confidence: 99%