Altered P300 Topography in Schizophrenia

Amplitudes of Auditory P300 in Remitted and Residual Schizophrenics: Correlations with Clinical Features

“…3). This result is compatible with the asymme tries described by Morstyn et al [8] and by Faux et al [10], P300 electric field activity may be considered the sum of activities of at least two different generators (left and right hippocampal-parahippocampal areas [26]). Dis location to the right hemisphere of the extrema can be explained by reduced activity of left hemispheric genera tors.…”

Genetics and intermediate phenotypes of the schizophrenia—bipolar disorder boundary

“…P300 ERP was first reported as abnormal, both in latency and in amplitude, in SZ by Roth et al (1981) . These findings were subsequently confirmed by several other laboratories in SZ patients ( Faux et al, 1993 ; Ford et al, 1999a , b , 2000 ; Morstyn et al, 1983 ; Strik et al, 1994 ; Turetsky et al, 1998 ), first-episode SZ ( de Wilde et al, 2008 ; Salisbury et al, 1998 ), SZ prodrom ( Frommann et al, 2008 ) and SZ spectrum personality disorders ( Salisbury et al, 1996 ). Several groups showed alterations in P300 in clinically affected and unaffected siblings of SZ probands ( Bharath et al, 2000 ; Blackwood et al, 1991 ; Condray et al, 1992 ; Kidogami et al, 1991 ; Price et al, 2006 ; Roxborough et al, 1993 ; Saitoh et al, 1984 ).…”

P300 in schizophrenia: Interactions between amplitudes and topography

“…Such an interaction is relevant, because even in multichannel studies only P300 amplitudes at midline are reponed as estimators of the field strength, and P300 asymmetries in schizophrenics have been repeatedly demonstrated (Morstyn et al 1983;Faux et aJ 1990;Strik et al 1993a). In the present study, we found the standard P300 amplitude at midline electrodes to be significantly asso· ciated with topographical asymmetries of the electrical field.…”