2015
DOI: 10.1016/j.neuroscience.2015.09.022
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Abstract: HighlightsPrenatal kynurenine or kynurenine monoxygenase deletion reduced adult hippocampal LTP.There were no changes in expression of NMDA receptors or neurodevelopmental proteins.The reduced LTP was reversed by galantamine which potentiates NMDAR activation.Modifying kynurenine metabolism prenatally disturbs brain development in adulthood.