PLoS ONE volume 9, issue 5, Pe98382 2014 DOI: 10.1371/journal.pone.0098382 View full text
Ihssane Zouikr, Morgan H. James, Erin J. Campbell, Vicki L. Clifton, Kenneth W. Beagley, Christopher V. Dayas, Deborah M. Hodgson

Abstract: Animal and human studies have demonstrated that early pain experiences can produce alterations in the nociceptive systems later in life including increased sensitivity to mechanical, thermal, and chemical stimuli. However, less is known about the impact of neonatal immune challenge on future responses to noxious stimuli and the reactivity of neural substrates involved in analgesia. Here we demonstrate that rats exposed to Lipopolysaccharide (LPS; 0.05 mg/kg IP, Salmonella enteritidis) during postnatal day (PND…

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