2010
DOI: 10.1007/s11605-010-1202-2
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Abstract: MiR-148a and miR-152 may be involved in the carcinogenesis of gastrointestinal cancers and might be potential biomarkers in these cancers.

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Cited by 185 publications
(150 citation statements)
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References 30 publications
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“…However, recently Chen et al found that miR-148a expression was lower in tumour tissues compared with tissues adjacent to the tumour tissue, and low miR-148 expression correlated with increased tumour size and advanced colorectal adenocarcinoma stage. 24 This previous study showed that miR-148a was involved in colorectal cancer metastasis, but they focused on the correlation between miR-148a hypermethylation and metastasis. 18 The main cause of the disparity between these and our results was that we only analysed 42 primary tumour The new role for miR-148 has been demonstrated in the present work, namely that it is a pro-apoptotic miRNA, which operates by targeting Bcl-2.…”
Section: Discussionmentioning
confidence: 99%
“…However, recently Chen et al found that miR-148a expression was lower in tumour tissues compared with tissues adjacent to the tumour tissue, and low miR-148 expression correlated with increased tumour size and advanced colorectal adenocarcinoma stage. 24 This previous study showed that miR-148a was involved in colorectal cancer metastasis, but they focused on the correlation between miR-148a hypermethylation and metastasis. 18 The main cause of the disparity between these and our results was that we only analysed 42 primary tumour The new role for miR-148 has been demonstrated in the present work, namely that it is a pro-apoptotic miRNA, which operates by targeting Bcl-2.…”
Section: Discussionmentioning
confidence: 99%
“…The dysregulated miRNAs and their confirmed targets are listed in Supplementary Table 1 (Volinia et al, 2006;Zhang et al, 2007aZhang et al, , 2008Zhang et al, , 2009Zhang et al, , 2010Kim do et al, 2007;Chan et al, 2008;Choy et al, 2008;Petrocca et al, 2008;Ando et al, 2009;Bandres et al, 2009;Du et al, 2009;Guo et al, 2009;Katada et al, 2009;Kim et al, 2009;Liu et al, 2009;Saito et al, 2009;Takagi et al, 2009;Chen et al, 2010;Fassi Fehri et al, 2010;Gao et al, 2010;Hashimoto et al, 2010;Jiang et al, 2010;Lai et al, 2010;Matsushima et al, 2010;Motoyama et al, 2008Motoyama et al, , 2010Shen et al, 2010;Shinozaki et al, 2010;Tsujiura et al, 2010;Tsukamoto et al, 2010;Ueda et al, 2010;Wan et al, 2010;Wu et al, 2010a;Xia et al, 2008;Xiao et al, 2009;Zhu et al, 2010).…”
Section: Dysregulated Mirnas In Gastric Cancermentioning
confidence: 99%
“…Cummins et al (13) indicated that 53 miRNAs were expressed at significantly different levels between CRC tissues and normal colonic epithelium by microarray and qRT-PCR methods. Moreover, Chen et al (14) indicated that miR-148a and -152 were downregulated, as shown by real-time PCR assay, in a large number of cases with CRC and were significantly related to tumor size and depth of invasion. Our previous study showed similar results, in that miR-203 was significantly downregulated in CRC by real-time PCR assay.…”
mentioning
confidence: 99%