Altered Expression of MiR-148a and MiR-152 in Gastrointestinal Cancers and Its Clinical Significance

Abstract

MiR-148a and miR-152 may be involved in the carcinogenesis of gastrointestinal cancers and might be potential biomarkers in these cancers.

MiR-148a promotes apoptosis by targeting Bcl-2 in colorectal cancer

“…However, recently Chen et al found that miR-148a expression was lower in tumour tissues compared with tissues adjacent to the tumour tissue, and low miR-148 expression correlated with increased tumour size and advanced colorectal adenocarcinoma stage. 24 This previous study showed that miR-148a was involved in colorectal cancer metastasis, but they focused on the correlation between miR-148a hypermethylation and metastasis. 18 The main cause of the disparity between these and our results was that we only analysed 42 primary tumour The new role for miR-148 has been demonstrated in the present work, namely that it is a pro-apoptotic miRNA, which operates by targeting Bcl-2.…”

MicroRNA dysregulation in gastric cancer: a new player enters the game

“…The dysregulated miRNAs and their confirmed targets are listed in Supplementary Table 1 (Volinia et al, 2006;Zhang et al, 2007aZhang et al, , 2008Zhang et al, , 2009Zhang et al, , 2010Kim do et al, 2007;Chan et al, 2008;Choy et al, 2008;Petrocca et al, 2008;Ando et al, 2009;Bandres et al, 2009;Du et al, 2009;Guo et al, 2009;Katada et al, 2009;Kim et al, 2009;Liu et al, 2009;Saito et al, 2009;Takagi et al, 2009;Chen et al, 2010;Fassi Fehri et al, 2010;Gao et al, 2010;Hashimoto et al, 2010;Jiang et al, 2010;Lai et al, 2010;Matsushima et al, 2010;Motoyama et al, 2008Motoyama et al, , 2010Shen et al, 2010;Shinozaki et al, 2010;Tsujiura et al, 2010;Tsukamoto et al, 2010;Ueda et al, 2010;Wan et al, 2010;Wu et al, 2010a;Xia et al, 2008;Xiao et al, 2009;Zhu et al, 2010).…”

microRNA-192, -194 and -215 are frequently downregulated in colorectal cancer

“…Cummins et al (13) indicated that 53 miRNAs were expressed at significantly different levels between CRC tissues and normal colonic epithelium by microarray and qRT-PCR methods. Moreover, Chen et al (14) indicated that miR-148a and -152 were downregulated, as shown by real-time PCR assay, in a large number of cases with CRC and were significantly related to tumor size and depth of invasion. Our previous study showed similar results, in that miR-203 was significantly downregulated in CRC by real-time PCR assay.…”