Altered dopamine D2 receptor function in fibromyalgia patients: a neuroendocrine study with buspirone in women with fibromyalgia compared to female population based controls

Malt, Eva Albertsen; Ólafsson, Snorri; Aakvaag, Asbjoern; Lund, Anders; Ursin, Holger

doi:10.1016/s0165-0327(02)00025-3

Cited by 67 publications

(43 citation statements)

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“…A review of research findings suggests this may indeed be the case. As noted, FM is associated with increased prolactin release in response to dopamine antagonism, which is indicative of a denervation hypersensitivity as would be expected in the context of reduced dopaminergic activity 9 . Other neuroendocrine abnormalities among subsets of FM patients include attenuated growth hormone response to physiological challenge 28 and mild hypocortisolemia 29 .…”

Section: Rheumatologymentioning

confidence: 65%

“…Indirect pharmacological evidence of dopaminergic dysfunction in FM was first provided by Malt, et al, who reported that FM patients had an augmented prolactin release in response to a single challenge dose of buspirone in comparison with controls 9 . Given that the release of prolactin in response to buspirone has been related to the medication's putative activity as a partial dopamine antagonist, the authors concluded that FM may be characterized by increased sensitivity or density of dopamine D2 receptors, which would be in keeping with functional denervation hypersensitivity.…”

mentioning

confidence: 99%

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An Elephant Among Us: The Role of Dopamine in the Pathophysiology of Fibromyalgia

Wood¹,

Holman²

2009

J Rheumatol

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Section: Rheumatologymentioning

confidence: 65%

mentioning

confidence: 99%

An Elephant Among Us: The Role of Dopamine in the Pathophysiology of Fibromyalgia

Wood¹,

Holman²

2009

J Rheumatol

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“…Dopamine D2 receptors have been shown to have increased sensitivity and density in patients with FM (41). There is a decrease in presynaptic dopamine activity in positron emission tomography studies (42).…”

Section: Discussionmentioning

confidence: 99%

The Prevalence of Fibromyalgia in Patients with Restless Legs Syndrome

Yılmaz¹,

Cantürk²,

Düz³

et al. 2016

tnd

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Objective: To determine the prevalence of fibromyalgia (FM) in patients with Restless legs syndrome (RLS), and to evaluate the relationship of FM and the scales of quality of life. Materials and Methods:Thirty patients aged between 18-65 years (20 females, 10 males) with RLS and 30 healthy control subjects (17 female, 13 male) participated in our study. The patients were assessed using the the RLS Severity Rating Scale. The Pittsburg Sleep Quality Index (PSQI), Beck Depression Inventory, Beck Anxiety Questionnaire, and Quality of Life Short form-36 (SF-36) were given to both the patient and control group. The American College of Rheumatology criteria were used to diagnose FM. Results:The average age of the patients was 44.73±11.23 years, the average age of the control group was 46.00±12.23 years. The prevalence of FM was 36.7% in the patient group and 6.7% in the control group (p=0.01). PSQI, depression and anxiety scores were significantly worse in the patient group (p=0.0001; p=0.004; p=0.000). The patients with RLS had higher scores of mental health, social functioning, pain, and general perception of SF-36, and scale for the evaluation of quality of life (p=0.004; p=0.023; p<0.001; p=0.001; p=0.13); the scores for physical and emotional limitations did not differ between the patient and the control group. However, if a patient with RLS had additional FM symptoms, the general perception scores of the body were worse (p=0.029). When we compared the scores of the patients with both RLS and FM with the healthy group, the anxiety scores were the most increased (three times). Conclusion:The prevelance of FM was frequent (36.67%) in patients with moderate and severe RLS. RLS impairs quality of life. However, coexistence of the two diseases only worsened patients' assessments of their own health score, and affected their anxiety scores the most.

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“…Dopaminergic neurotransmission was found to be altered in fibromyalgia patients by Malt and colleagues. They suggested an increased sensitivity or density of dopamine D 2 receptors in fibromyalgia patients (Malt et al, 2003). Buskila and collaborators demonstrated an association between fibromyalgia and the 7-repeat allele in exon III of the D 4 receptor gene, specifically that the frequency of this polymorphism was significantly lower in people with fibromyalgia (Buskila et al, 2004).…”

Section: Wwwintechopencommentioning

confidence: 99%