Altered Distribution of Basic Fibroblast Growth Factor in Diabetic Retinopathy

Pars plana vitrectomy for diabetic macular edema. Internal limiting membrane delamination vs posterior hyaloid removal. A prospective randomized trial

“…Furthermore, AGEs can enhance VEGF production and thereby induce permeability changes. The finding of bFGF in the ILMs of diabetic eyes supports previous data showing bFGF deposits in the inner limiting membranes of retinae from diabetic patients [36], and of experimentally diabetic animals [37]. It is worth noting that bFGF is an important repair/survival factor for retinal glia suggesting that our finding is consistent with increased repair, rather than a sign of damage.…”

Pars plana vitrectomy for diabetic macular edema. Internal limiting membrane delamination vs posterior hyaloid removal. A prospective randomized trial

“…Furthermore, AGEs can enhance VEGF production and thereby induce permeability changes. The finding of bFGF in the ILMs of diabetic eyes supports previous data showing bFGF deposits in the inner limiting membranes of retinae from diabetic patients [36], and of experimentally diabetic animals [37]. It is worth noting that bFGF is an important repair/survival factor for retinal glia suggesting that our finding is consistent with increased repair, rather than a sign of damage.…”

In situ Localization of Basic Fibroblast Growth Factor Protein and mRIMA in the Retina

“…Our immunohistochcmical results were similar to those of Hanneken et al [9,10] and Ishigooka et al [11], but we could not ascer tain the presence of basic FGF protein in the cytoplasm of the retinal pigment epithelium based on our immunoperoxidase method.…”

Detection of Vascular Endothelial Growth Factor Messenger RNA and Vascular Endothelial Growth Factor-like Activity in Proliferative Diabetic Retinopathy

“…The analysis of the expression of the different growth factors showed that VEGF was the only one that was expressed in all of the samples, while the mRNA of the other angiogenic factors were occasionally or never detected. For example, the mRNA of bFGF were found in only two of 14 membrane samples; this finding was consis¬ tent with that of the immunohistochemical analysis of Han¬ neken et al 31 Platelet-derived endothelial cell growth fac¬ tor, insulinlike growth factor I, and aFGF were found in 1, Figure 1. Detection of vascular endothelial growth factor messenger RNA in neovascular membrane samples by reverse transcription-polymerase chain reaction analysis.…”

Pars plana vitrectomy for diabetic macular edema. Internal limiting membrane delamination vs posterior hyaloid removal. A prospective randomized trial

“…Furthermore, AGEs can enhance VEGF production and thereby induce permeability changes. The finding of bFGF in the ILMs of diabetic eyes supports previous data showing bFGF deposits in the inner limiting membranes of retinae from diabetic patients [36], and of experimentally diabetic animals [37]. It is worth noting that bFGF is an important repair/survival factor for retinal glia suggesting that our finding is consistent with increased repair, rather than a sign of damage.…”

In situ Localization of Basic Fibroblast Growth Factor Protein and mRIMA in the Retina

“…Our immunohistochcmical results were similar to those of Hanneken et al [9,10] and Ishigooka et al [11], but we could not ascer tain the presence of basic FGF protein in the cytoplasm of the retinal pigment epithelium based on our immunoperoxidase method.…”

Detection of Vascular Endothelial Growth Factor Messenger RNA and Vascular Endothelial Growth Factor-like Activity in Proliferative Diabetic Retinopathy

“…The analysis of the expression of the different growth factors showed that VEGF was the only one that was expressed in all of the samples, while the mRNA of the other angiogenic factors were occasionally or never detected. For example, the mRNA of bFGF were found in only two of 14 membrane samples; this finding was consis¬ tent with that of the immunohistochemical analysis of Han¬ neken et al 31 Platelet-derived endothelial cell growth fac¬ tor, insulinlike growth factor I, and aFGF were found in 1, Figure 1. Detection of vascular endothelial growth factor messenger RNA in neovascular membrane samples by reverse transcription-polymerase chain reaction analysis.…”

Pars plana vitrectomy for diabetic macular edema. Internal limiting membrane delamination vs posterior hyaloid removal. A prospective randomized trial

“…Furthermore, AGEs can enhance VEGF production and thereby induce permeability changes. The finding of bFGF in the ILMs of diabetic eyes supports previous data showing bFGF deposits in the inner limiting membranes of retinae from diabetic patients [36], and of experimentally diabetic animals [37]. It is worth noting that bFGF is an important repair/survival factor for retinal glia suggesting that our finding is consistent with increased repair, rather than a sign of damage.…”

In situ Localization of Basic Fibroblast Growth Factor Protein and mRIMA in the Retina

“…Our immunohistochcmical results were similar to those of Hanneken et al [9,10] and Ishigooka et al [11], but we could not ascer tain the presence of basic FGF protein in the cytoplasm of the retinal pigment epithelium based on our immunoperoxidase method.…”

Detection of Vascular Endothelial Growth Factor Messenger RNA and Vascular Endothelial Growth Factor-like Activity in Proliferative Diabetic Retinopathy

“…The analysis of the expression of the different growth factors showed that VEGF was the only one that was expressed in all of the samples, while the mRNA of the other angiogenic factors were occasionally or never detected. For example, the mRNA of bFGF were found in only two of 14 membrane samples; this finding was consis¬ tent with that of the immunohistochemical analysis of Han¬ neken et al 31 Platelet-derived endothelial cell growth fac¬ tor, insulinlike growth factor I, and aFGF were found in 1, Figure 1. Detection of vascular endothelial growth factor messenger RNA in neovascular membrane samples by reverse transcription-polymerase chain reaction analysis.…”