Altered dietary salt intake for preventing and treating diabetic kidney disease

Abstract

Although the studies are not extensive, this meta-analysis shows a large fall in BP with salt restriction, similar to that of single drug therapy. All diabetics should consider reducing salt intake at least to less than 5-6 g/day in keeping with current recommendations for the general population and may consider lowering salt intake to lower levels, although further studies are needed.

Multidisciplinary Team Care Delays the Initiation of Renal Replacement Therapy in Diabetes: A Five-year Prospective, Single-center Study

“…First, we were unable to clarify the elements of MTC education that most significantly contributed to delaying the initiation of RRT. Although previous reports pointed out the effect of salt or protein restriction on the maintenance of the renal function (21,22), we found no marked change in the salt or protein intake during the first observation year despite continuous nutritional support. Furthermore, other main parameters, such as the BP, HbA1c, and urine protein, showed no significant improvement during the first observation year.…”

Multidisciplinary Team Care Delays the Initiation of Renal Replacement Therapy in Diabetes: A Five-year Prospective, Single-center Study

“…First, we were unable to clarify the elements of MTC education that most significantly contributed to delaying the initiation of RRT. Although previous reports pointed out the effect of salt or protein restriction on the maintenance of the renal function (21,22), we found no marked change in the salt or protein intake during the first observation year despite continuous nutritional support. Furthermore, other main parameters, such as the BP, HbA1c, and urine protein, showed no significant improvement during the first observation year.…”

A randomized trial of sodium-restriction on kidney function, fluid volume and adipokines in CKD patients

“…This is consistent with findings from other studies investigating the effect of sodium load on creatinine clearance showing that a high sodium intake can result in increased creatinine clearance, at least in the short term [20]. This can be attributed to induced hyperfiltration associated with increased intraglomerular pressure [21,22].…”

The Effect of Diet on the Survival of Patients with Chronic Kidney Disease

“…However, in the small single-center double-blind randomized cross-over trial LowSALT CKD, a significant change was observed in kidney function parameters, with a low sodium diet resulting in a decrease in eGFR of hypertensive stage III–IV CKD patients, reflected by an increase in creatinine and urate in comparison to high sodium diet [ 79 ]. Similar results were obtained by Suckling et al [ 80 ] in which a high sodium intake resulted in increased creatinine clearance, at least in the short term in patients with type 1 and type 2 diabetes. This phenomenon could be ascribed to induced hyperfiltration associated with increased intraglomerular pressure [ 81 ].…”

Multidisciplinary Team Care Delays the Initiation of Renal Replacement Therapy in Diabetes: A Five-year Prospective, Single-center Study

“…First, we were unable to clarify the elements of MTC education that most significantly contributed to delaying the initiation of RRT. Although previous reports pointed out the effect of salt or protein restriction on the maintenance of the renal function (21,22), we found no marked change in the salt or protein intake during the first observation year despite continuous nutritional support. Furthermore, other main parameters, such as the BP, HbA1c, and urine protein, showed no significant improvement during the first observation year.…”

A randomized trial of sodium-restriction on kidney function, fluid volume and adipokines in CKD patients

“…This is consistent with findings from other studies investigating the effect of sodium load on creatinine clearance showing that a high sodium intake can result in increased creatinine clearance, at least in the short term [20]. This can be attributed to induced hyperfiltration associated with increased intraglomerular pressure [21,22].…”

The Effect of Diet on the Survival of Patients with Chronic Kidney Disease

“…However, in the small single-center double-blind randomized cross-over trial LowSALT CKD, a significant change was observed in kidney function parameters, with a low sodium diet resulting in a decrease in eGFR of hypertensive stage III–IV CKD patients, reflected by an increase in creatinine and urate in comparison to high sodium diet [ 79 ]. Similar results were obtained by Suckling et al [ 80 ] in which a high sodium intake resulted in increased creatinine clearance, at least in the short term in patients with type 1 and type 2 diabetes. This phenomenon could be ascribed to induced hyperfiltration associated with increased intraglomerular pressure [ 81 ].…”

Multidisciplinary Team Care Delays the Initiation of Renal Replacement Therapy in Diabetes: A Five-year Prospective, Single-center Study

“…First, we were unable to clarify the elements of MTC education that most significantly contributed to delaying the initiation of RRT. Although previous reports pointed out the effect of salt or protein restriction on the maintenance of the renal function (21,22), we found no marked change in the salt or protein intake during the first observation year despite continuous nutritional support. Furthermore, other main parameters, such as the BP, HbA1c, and urine protein, showed no significant improvement during the first observation year.…”

A randomized trial of sodium-restriction on kidney function, fluid volume and adipokines in CKD patients

“…This is consistent with findings from other studies investigating the effect of sodium load on creatinine clearance showing that a high sodium intake can result in increased creatinine clearance, at least in the short term [20]. This can be attributed to induced hyperfiltration associated with increased intraglomerular pressure [21,22].…”

The Effect of Diet on the Survival of Patients with Chronic Kidney Disease

“…However, in the small single-center double-blind randomized cross-over trial LowSALT CKD, a significant change was observed in kidney function parameters, with a low sodium diet resulting in a decrease in eGFR of hypertensive stage III–IV CKD patients, reflected by an increase in creatinine and urate in comparison to high sodium diet [ 79 ]. Similar results were obtained by Suckling et al [ 80 ] in which a high sodium intake resulted in increased creatinine clearance, at least in the short term in patients with type 1 and type 2 diabetes. This phenomenon could be ascribed to induced hyperfiltration associated with increased intraglomerular pressure [ 81 ].…”