Altered cytokine production by dendritic cells from infants with atopic dermatitis

Yao, Weiguo; Chang, Ji Hoon; Sehra, Sarita; Travers, Jeffrey B.; Chang, Cheong Hee; Tepper, Robert S.; Kaplan, Mark H.

doi:10.1016/j.clim.2010.09.001

Cited by 9 publications

(5 citation statements)

References 33 publications

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“…We have previously established that there are systemic effects of Stat6VT Tg expression in T cells (810). Indeed, we previously observed that dendritic cells in neonatal mice from Stat6VT Tg dams exhibited altered cytokine production that was similar to patterns observed in infants from atopic mothers (5,31). This suggests that although FucT-VII deficiency is protective for allergic skin inflammation in the absence of additional proatopic signals, the effects of an atopic environment on the infants immune system can overcome that protection.…”

Section: Discussionsupporting

confidence: 52%

Selectin Dependence of Allergic Skin Inflammation Is Diminished by Maternal Atopy

et al. 2021

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Allergic skin inflammation requires the influx of inflammatory cells into the skin. Extravasation of leukocytes into the skin requires interactions between endothelial selectins and their glycan ligands on the surface of leukocytes. Selectin-ligand formation requires the activity of several glycosyltransferases, including Fut7. In this report, we tested the importance of Fut7 for the development of allergic skin inflammation in the Stat6VT transgenic mouse model. We observed that Fut7 deficiency was protective but did not eliminate disease. Segregation of the data by gender of the parent that transmitted the Stat6VT transgene, but not by gender of the pups, which were analyzed for disease, revealed that the protective effects of Fut7 deficiency were significantly greater when dams were Stat6VT negative. In contrast, in mice from litters of Stat6VT + dams, Fut7 deficiency resulted in only modest protection. These findings indicate that pups from atopic dams exhibit a greater propensity for allergic disease, similar to observations in humans, and that the effect of maternal atopy is due to enhanced selectin-independent mechanisms of leukocyte recruitment in their offspring. Together, these results demonstrate that Fut7 deficiency can be protective in a model of atopic dermatitis but that maternal atopy diminishes these protective effects, suggesting alternative pathways for leukocyte recruitment in the absence of Fut7 enzyme activity. These observations have implications for understanding how the environment in utero predisposes for the development of allergic disease. ImmunoHorizons, 2021, 5: 703-710.

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Section: Discussionsupporting

confidence: 52%

Selectin Dependence of Allergic Skin Inflammation Is Diminished by Maternal Atopy

et al. 2021

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“…Supporting this notion is a recent study that reported that several specific conditions can stimulate innate immune system (like toll-like receptor 4) that this induces TSLP expression [28,29,30]. Metabolic changes (including ROS generation) in the local milieu may program innate immune system at the site of inflammation to produce Type 2 responses [28,31].…”

Section: Discussionmentioning

confidence: 73%

Mold elicits atopic dermatitis by reactive oxygen species: Epidemiology and mechanism studies

Kim

Lee

et al. 2015

Clinical Immunology

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“…A prior study demonstrated elevated IL-6 production by T cells derived from patients with AD ( 72 ). Additionally, IL-6 is generated by various cell types, including dendritic cells, mast cells, eosinophils, and keratinocytes ( 73 – 76 ). After the application of MC903 in Fut1- KO mice, there was a significantly elevated production of IL-6 in the skin, along with increased infiltration of mast cells and eosinophils compared to WT mice.…”

Section: Discussionmentioning

confidence: 99%

Impact of fucosyltransferase 1-mediated epidermal blood group antigen H on anti-inflammatory response in atopic dermatitis

Li,

Oh,

Suh

et al. 2024

Front. Immunol.

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The presence of the blood group H2 antigen on the membrane of red blood cells determines blood type O in individuals and this H2 antigen serves as a precursor to the A and B antigens expressed in blood types A and B, respectively. However, the specific involvement of ABH antigens in skin diseases is unknown. Therefore, we aim to investigate the expression of ABH antigens in skin tissue of patients with atopic dermatitis (AD) and MC903-induced AD-like mice. We demonstrated that the expression of ABH antigen is primarily located in the granular and horny layers of the skin in healthy control individuals. However, in patients with AD, the expression of the ABH antigen was absent or diminished in these layers, while the H2 antigen expression increased in the spinous layers of the affected skin lesions. Then, we investigated the biological function of blood group H antigen mediated by fucosyltransferase 1 (Fut1) in the skin, utilizing an AD mouse model induced by MC903 in wild-type (WT) and Fut1-knockout mice. After the application of MC903, Fut1-deficient mice, with no H2 antigen expression on their skin, exhibited more severe clinical signs, increased ear swelling, and elevated serum IgE levels compared with those of WT mice. Additionally, the MC903-induced thickening of both the epidermis and dermis was more pronounced in Fut1-deficient mice than that in WT mice. Furthermore, Fut1-deficient mice showed a significantly higher production of interleukin-4 (IL-4) and IL-6 in skin lesions compared with that of their WT counterparts. The expression of chemokines, particularly Ccl2 and Ccl8, was notably higher in Fut1-deficient mice compared with those of WT mice. The infiltration of CD4+ T cells, eosinophils, and mast cells into the lesional skin was significantly elevated in Fut1-deficient mice compared with that in WT mice. These findings demonstrate the protective role of H2 antigen expression against AD-like inflammation and highlight its potential therapeutic impact on AD through the regulation of blood group antigens.

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Altered cytokine production by dendritic cells from infants with atopic dermatitis

Cited by 9 publications

References 33 publications

Selectin Dependence of Allergic Skin Inflammation Is Diminished by Maternal Atopy

Selectin Dependence of Allergic Skin Inflammation Is Diminished by Maternal Atopy

Mold elicits atopic dermatitis by reactive oxygen species: Epidemiology and mechanism studies

Impact of fucosyltransferase 1-mediated epidermal blood group antigen H on anti-inflammatory response in atopic dermatitis

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