volume 29, issue 1, P125-132 2012
DOI: 10.3233/jad-2012-111655
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Malin Wennström, Elisabet Londos, Lennart Minthon, Henrietta M Nielsen

Abstract: Neurodegenerative dementia, most frequently represented by Alzheimer's disease (AD) and dementia with Lewy bodies (DLB), is often accompanied by altered sleeping patterns and excessive daytime sleepiness. Studies showing an association between the neuropeptide orexin and AD/DLB-related processes such as amyloid-β (Aβ)1-42 plaque formation, α-synuclein accumulation and inflammation indicate that orexin might play a pathogenic role similar to the situation in narcolepsy. Our study of patients with AD (n = 26), D…

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