Altered Cerebellar Oscillations in Parkinson’s Disease Patients during Cognitive and Motor Tasks

Bosch, Taylor J.; Groth, Christopher L.; Eldridge, Tiffany A.; Gnimpieba, Etienne Z.; Baugh, Lee A.; Singh, Arun Kumar

doi:10.1016/j.neuroscience.2021.08.021

Cited by 17 publications

(13 citation statements)

References 62 publications

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“…Connectivity analysis between the mid-frontal and mid-cerebellar regions depicted differences in theta band during the motor task but not the cognitive task. As compared to controls, PD patients demonstrated altered cerebellar oscillations in the cognitive and motor tasks [70].…”

Section: Cerebellar Physiology In Tremormentioning

confidence: 91%

Physiological Recordings of the Cerebellum in Movement Disorders

et al. 2022

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The cerebellum plays an important role in movement disorders, specifically in symptoms of ataxia, tremor, and dystonia. Understanding the physiological signals of the cerebellum contributes to insights into the pathophysiology of these movement disorders and holds promise in advancing therapeutic development. Non-invasive techniques such as electroencephalogram and magnetoencephalogram can record neural signals with high temporal resolution at the millisecond level, which is uniquely suitable to interrogate cerebellar physiology. These techniques have recently been implemented to study cerebellar physiology in healthy subjects as well as individuals with movement disorders. In the present review, we focus on the current understanding of cerebellar physiology using these techniques to study movement disorders.

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Section: Cerebellar Physiology In Tremormentioning

confidence: 91%

Physiological Recordings of the Cerebellum in Movement Disorders

et al. 2022

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“…Additionally, another EEG study showed profoundly lower power in theta band in both mid-cerebellar and mid-frontal regions during the postural control task in PD patients with postural instability when compared to PD patients without postural instability and healthy control groups (Bosch et al, 2021c). Moreover, cerebellar beta oscillations showed no association with gait impairment in PD (Bosch et al, 2021a). A dual-task functional MRI study demonstrated activation in the right cerebellar vermis and left lobule V of the cerebellar anterior lobe, illustrating that some cerebellar regions can be additionally activated with dual-task performance .…”

Section: Oscillations In the Cerebellar Regionmentioning

confidence: 94%

“…Recent cerebellar EEG study observed increased theta-band oscillations in PD patients compared to age-matched healthy controls, suggesting the pathophysiological role of cerebellar oscillations in PD ( Bosch et al, 2021b ). The same research group further studied cerebellar oscillations during lower-limb movements and temporal cognitive processing tasks in PD patients, demonstrating attenuated cue-triggered theta-band power over a mid-cerebellar electrode during both tasks ( Bosch et al, 2021a ). The cue-triggered mid-cerebellar theta activity in the lower-limb pedaling motor task was also correlated with gait and cognitive impairments in PD ( Bosch et al, 2021a ).…”

Section: Subcortical Oscillations During Gait and Dual-taskmentioning

confidence: 99%

“…The same research group further studied cerebellar oscillations during lower-limb movements and temporal cognitive processing tasks in PD patients, demonstrating attenuated cue-triggered theta-band power over a mid-cerebellar electrode during both tasks ( Bosch et al, 2021a ). The cue-triggered mid-cerebellar theta activity in the lower-limb pedaling motor task was also correlated with gait and cognitive impairments in PD ( Bosch et al, 2021a ). Similar results have been discussed by De Zeeuw and colleagues, where cerebellar cortical theta band oscillations (4–9 Hz) were attributed to learning-dependent timing ( De Zeeuw et al, 2008 ).…”

Section: Subcortical Oscillations During Gait and Dual-taskmentioning

confidence: 99%

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Abnormal neural oscillations during gait and dual-task in Parkinson’s disease

Nwogo

Kammermeier

Singh

2022

Front. Syst. Neurosci.

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Gait dysfunctions are debilitating motor symptoms of Parkinson’s disease (PD) and may result in frequent falling with health complications. The contribution of the motor-cognitive network to gait disturbance can be studied more thoroughly by challenging motor-cognitive dual-task gait performances. Gait is a complex motor task that requires an appropriate contribution from motor and cognitive networks, reflected in frequency modulations among several cortical and subcortical networks. Electrophysiological recordings by scalp electroencephalography and implanted deep brain stimulation (DBS) electrodes have unveiled modulations of specific oscillatory patterns in the cortical-subcortical circuits in PD. In this review, we summarize oscillatory contributions of the cortical, basal ganglia, mesencephalic locomotor, and cerebellar regions during gait and dual-task activities in PD. We detail the involvement of the cognitive network in dual-task settings and compare how abnormal oscillations in the specific frequency bands in the cortical and subcortical regions correlate with gait deficits in PD, particularly freezing of gait (FOG). We suggest that altered neural oscillations in different frequencies can cause derangements in broader brain networks, so neuromodulation and pharmacological therapies should be considered to normalize those network oscillations to improve challenged gait and dual-task motor functions in PD. Specifically, the theta and beta bands in premotor cortical areas, subthalamic nucleus, as well as alpha band activity in the brainstem prepontine nucleus, modulate under clinically effective levodopa and DBS therapies, improving gait and dual-task performance in PD with FOG, compared to PD without FOG and age-matched healthy control groups.

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“…1,14,44 To our knowledge, the current understanding of CBLv changes in Parkinson's disease are limited to results from imaging studies which measure activity indirectly by coupling activity to increases in blood flow 20 and EEG recordings, which have limited spatial resolution. 19 (which was not certified by peer review) is the author/funder. All rights reserved.…”

Section: Introductionmentioning

confidence: 99%

Cerebellar Activity in Hemi-Parkinsonian Rats during Volitional Gait and Freezing

DeAngelo

Gehan

Paliwal

et al. 2023

Preprint

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Parkinson’s disease is a neurodegenerative disease characterized by gait dysfunction in the advanced stages of the disease. The unilateral 6-OHDA toxin-induced model is the most studied animal model of Parkinson’s disease, which reproduces gait dysfunction after greater than 68% dopamine (DA) loss in the substantia nigra pars compacta (SNc). The extent to which the neural activity in hemi-parkinsonian rats correlates to gait dysfunction and DAergic cell loss is not clear. In this paper we report the effects of unilateral DA depletion on cerebellar vermis activity using micro-electrocorticography (μECoG) during walking and freezing on a runway. Gait and neural activity were measured in 6-OHDA lesioned and sham lesioned rats at 14d, 21d, and 28d after infusion of 6-OHDA or control vehicle into the medial forebrain bundle (MFB) (n=20). Gait deficits in 6-OHDA rats were different from sham rats at 14d (p<0.05). Gait deficits in 6-OHDA rats improved at 21d and 28d except for run speed, which decreased at 28d (p=0.018). No differences in gait deficits were observed in sham lesioned rats at any time points. Hemiparkinsonian rats showed hyperactivity in the cerebellar vermis at 21d (p<0.05), but not at 14d and 28d, and the activity was reduced during freezing epochs in lobules VIa, VIb, and VIc (p<0.05). These results suggest that DAergic cell loss causes pathological cerebellar activity at 21d postlesion and suggests that compensatory mechanisms from the intact hemisphere contribute to normalized cerebellar activity at 28d. The decrease in cerebellar oscillatory activity during freezing may be indicative of neurological changes during freezing of gait in Parkinson’s disease patients making this region a potential location for biomarker detection. Although the unilateral 6-OHDA model presents gait deficits that parallel clinical presentations of Parkinson’s disease, further studies in animal models of bilateral DA loss are needed to understand the role of the cerebellar vermis in Parkinson’s disease.

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Altered Cerebellar Oscillations in Parkinson’s Disease Patients during Cognitive and Motor Tasks

Cited by 17 publications

References 62 publications

Physiological Recordings of the Cerebellum in Movement Disorders

Physiological Recordings of the Cerebellum in Movement Disorders

Abnormal neural oscillations during gait and dual-task in Parkinson’s disease

Cerebellar Activity in Hemi-Parkinsonian Rats during Volitional Gait and Freezing

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