Altered calcium signaling in cancer cells

Stewart, Teneale A.; Yapa, Kunsala T. D. S.; Monteith, Gregory R.

doi:10.1016/j.bbamem.2014.08.016

Cited by 288 publications

(254 citation statements)

References 175 publications

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“…Tumor development and progression depend not only on the perturbed genes that govern cell proliferation and apoptosis, but is also highly determined by tumor microenvironment (TME) (25,26). Extracellular matrix proteins constitute an integral part of TME and play critical roles in regulating tumor cell proliferation, survival, autophagy, migration and invasion.…”

Section: Discussionmentioning

confidence: 99%

The correlation of microRNA-181a and target genes with poor prognosis of glioblastoma patients

Huang¹,

Zhao²,

Weng³

et al. 2016

International Journal of Oncology

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Abstract. To investigate the expression and clinical significance of miR-181a and its target genes in glioblastoma multiforme (GBM), the expression levels of miR-181a and three target genes in human normal brain tissues and GBM were analyzed in silico using gene microarray, Gene Ontology, KEGG pathway and hierarchical clustering analysis followed by validation with quantitative RT-PCR. Our results show that miR-181a is down-regulated in GBM patients. The three target genes, ANGPT2, ARHGAP18 and LAMC1, are negatively correlated with the expression of miR-181a. Moreover, high expression of ANGPT2 or LAMC1 together with large size of GBM is correlated with a shorter median overall survival. In conclusion, our results showed that miR-181a and it targets ANGPT2 and LAMC1 might be predictors of prognosis in GBM patients.

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Section: Discussionmentioning

confidence: 99%

The correlation of microRNA-181a and target genes with poor prognosis of glioblastoma patients

Huang¹,

Zhao²,

Weng³

et al. 2016

International Journal of Oncology

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“…Regulation of the Ca 2ϩ signal can impact on many of the typical hallmarks of cancer such as sustained proliferation, resistance to cell death, and induction of angiogenesis (149,354). This had led to the study of Ca 2ϩ handling components during tumor development becoming an active field of research in recent years, with the TRP channel family leading the way, and may offer a number of novel pharmaceutical targets for the treatment of cancer (325).…”

Section: J Role Of Pmcas In Cancermentioning

confidence: 99%

The Plasma Membrane Calcium ATPasesand Their Role as Major New Players in Human Disease

Stafford

Wilson

Oceandy

et al. 2017

Physiological Reviews

107

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The Ca2+ extrusion function of the four mammalian isoforms of the plasma membrane calcium ATPases (PMCAs) is well established. There is also ever-increasing detail known of their roles in global and local Ca2+ homeostasis and intracellular Ca2+ signaling in a wide variety of cell types and tissues. It is becoming clear that the spatiotemporal patterns of expression of the PMCAs and the fact that their abundances and relative expression levels vary from cell type to cell type both reflect and impact on their specific functions in these cells. Over recent years it has become increasingly apparent that these genes have potentially significant roles in human health and disease, with PMCAs1-4 being associated with cardiovascular diseases, deafness, autism, ataxia, adenoma, and malarial resistance. This review will bring together evidence of the variety of tissue-specific functions of PMCAs and will highlight the roles these genes play in regulating normal physiological functions and the considerable impact the genes have on human disease.

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“…However, at the same time the excessive influx of calcium causes cell death and can also deregulate some cytosolic homeostasis processes. This intricacy in signaling of calcium means that the dysregulation of the calcium signal can be a feature of certain pathological states, including neurodegenerative diseases and cancer [68][69][70], or even acts as anti-tumor drug by increasing oxidative stress.…”

Section: Activation Of Trpv1 By Capsaicinmentioning

confidence: 99%

Can Capsaicin Present in Food Act as Carcinogenic, Antitumor or Both

Freitas¹

2014

CRJ

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Abstract:Pepper is amongst the most widely consumed spices in the world. However, what few people know, is that the pungent substance responsible for its blazing characteristic has many other biological properties, e.g. analgesic, antiinflammatory, antitumor and even carcinogenic. Several studies have discussed the antitumor and carcinogenic potential of this secondary metabolite. Nevertheless, the literature still lacks a comprehensive study relating the biological effects of capsaicin with the consumed dose, for both pharmacological and toxicological mechanisms. To solve this deficiency, the aim of this study was to discuss in details all the points mentioned above, in order to clarify the major questions about the subject.

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Altered calcium signaling in cancer cells

Cited by 288 publications

References 175 publications

The correlation of microRNA-181a and target genes with poor prognosis of glioblastoma patients

The correlation of microRNA-181a and target genes with poor prognosis of glioblastoma patients

The Plasma Membrane Calcium ATPasesand Their Role as Major New Players in Human Disease

Can Capsaicin Present in Food Act as Carcinogenic, Antitumor or Both

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