Altered attentional processing in male and female rats in a prenatal valproic acid exposure model of autism spectrum disorder

Anshu, Kumari; Nair, A. K.; Kumaresan, U.D.; Kutty, Bindu M.; Srinath, Shoba; Laxmi, T. Rao

doi:10.1002/aur.1852

Cited by 31 publications

(21 citation statements)

References 89 publications

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“…Similarly, in another study, males made more premature responses (impulsive action) when the ITI was long [33]. Additionally, male rats were found to be more impacted by a variable ITI, leading to more impulsive errors in 5CSRTT, while female performance remained robust, even in the face of increasing task difficulty [38]. However, another study using a two-choice task found that with increasing difficulty (long ITI), in adolescence, males were more impulsive than females, while as adults, females made more premature responses as compared to males [37].…”

Section: Sex Differences In Animals In Attention and Impulsive Actionmentioning

confidence: 73%

“…An investigation into prenatal drug use found that methamphetamine or methylphenidate given to dams during pregnancy affected the offspring, with both drugs increasing impulsive action in the offspring, with only very subtle sex differences observed [110]. Similarly, in an animal model used to examine autismrelated endophenotypes, valproic acid administration to pregnant dams increased inattention, with no effect on impulsivity, in both male and female offspring, with very minor task-dependent sex differences noted [38].…”

Section: Programmingmentioning

confidence: 99%

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Let’s call the whole thing off: evaluating gender and sex differences in executive function

Grissom

Reyes

2018

Neuropsychopharmacol

190

144

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The executive functions allow for purposeful, deliberate, and intentional interactions with the world-attention and focus, impulse control, decision making, and working memory. These measures have been correlated with academic outcomes and quality of life, and are impacted by deleterious environmental events throughout the life span, including gestational and early life insults. This review will address the topic of sex differences in executive function including a discussion of differences arising in response to developmental programming. Work on gender differences in human studies and sex differences in animal research will be reviewed. Overall, we find little support for significant gender or sex differences in executive function. An important variable that factors into the interpretation of potential sex differences include differing developmental trajectories. We conclude by discussing future directions for the field and a brief discussion of biological mechanisms.

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Section: Sex Differences In Animals In Attention and Impulsive Actionmentioning

confidence: 73%

Section: Programmingmentioning

confidence: 99%

Let’s call the whole thing off: evaluating gender and sex differences in executive function

Grissom

Reyes

2018

Neuropsychopharmacol

190

144

View full text Add to dashboard Cite

show abstract

“…Following prenatal valproic acid (VPA) treatment, an animal model of autism, male mice show impairments in social behavior in adulthood, while female mice do not (Kim et al, 2013 ). The prenatal VPA model also leads to male-specific deficits in sensorimotor gating, another phenotype of ASD (Anshu et al, 2017 ). Similar male-specific effects are seen in the telomerase reverse transcriptase overexpressing mice (TERT-tg).…”

Section: Sex Differences In Glutamate Systems In Diseasementioning

confidence: 99%

Sex Differences in Psychiatric Disease: A Focus on the Glutamate System

Wickens

Bangasser

Briand

2018

Front. Mol. Neurosci.

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Alterations in glutamate, the primary excitatory neurotransmitter in the brain, are implicated in several psychiatric diseases. Many of these psychiatric diseases display epidemiological sex differences, with either males or females exhibiting different symptoms or disease prevalence. However, little work has considered the interaction of disrupted glutamatergic transmission and sex on disease states. This review describes the clinical and preclinical evidence for these sex differences with a focus on two conditions that are more prevalent in women: Alzheimer's disease and major depressive disorder, and three conditions that are more prevalent in men: schizophrenia, autism spectrum disorder, and attention deficit hyperactivity disorder. These studies reveal sex differences at multiple levels in the glutamate system including metabolic markers, receptor levels, genetic interactions, and therapeutic responses to glutamatergic drugs. Our survey of the current literature revealed a considerable need for more evaluations of sex differences in future studies examining the role of the glutamate system in psychiatric disease. Gaining a more thorough understanding of how sex differences in the glutamate system contribute to psychiatric disease could provide novel avenues for the development of sex-specific pharmacotherapies.

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“…On the other hand, increased repetitive/stereotyped behaviors was observed in both male and female VPA-exposed rats [ 35 ]. In the visuospatial attention and sensorimotor gating behaviors, both male and female VPA rats showed similar levels of abnormalities with minor differences in specific parameters [ 36 ]. Mice exposed to VPA also exhibited a male-prevalent social deficit, manifested by reduced sniffing of a stranger mouse in the three-chamber assay, although both sexes have similar abnormalities in the open field and elevated plus maze tasks [ 37 ].…”

Section: Sex Differences In Environmental Models Of Autismmentioning

confidence: 99%

Sex-specific Behavioral Features of Rodent Models of Autism Spectrum Disorder

et al. 2018

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Sex is an important factor in understanding the clinical presentation, management, and developmental trajectory of children with neuropsychiatric disorders. While much is known about the clinical and neurobehavioral profiles of males with neuropsychiatric disorders, surprisingly little is known about females in this respect. Animal models may provide detailed mechanistic information about sex differences in autism spectrum disorder (ASD) in terms of manifestation, disease progression, and development of therapeutic options. This review aims to widen our understanding of the role of sex in autism spectrum disorder, by summarizing and comparing behavioral characteristics of animal models. Our current understanding of how differences emerge in boys and girls with neuropsychiatric disorders is limited: Information derived from animal studies will stimulate future research on the role of biological maturation rates, sex hormones, sex-selective protective (or aggravating) factors and psychosocial factors, which are essential to devise sex precision medicine and to improve diagnostic accuracy. Moreover, there is a strong need of novel strategies to elucidate the major mechanisms leading to sex-specific autism features, as well as novel models or methods to examine these sex differences.

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Altered attentional processing in male and female rats in a prenatal valproic acid exposure model of autism spectrum disorder

Cited by 31 publications

References 89 publications

Let’s call the whole thing off: evaluating gender and sex differences in executive function

Let’s call the whole thing off: evaluating gender and sex differences in executive function

Sex Differences in Psychiatric Disease: A Focus on the Glutamate System

Sex-specific Behavioral Features of Rodent Models of Autism Spectrum Disorder

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